{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T13:45:51Z","timestamp":1782740751034,"version":"3.54.5"},"reference-count":20,"publisher":"PAGEPress Publications","issue":"2","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatol Reports"],"abstract":"<jats:p>Dermatophyte infections, also known as tinea, along with viral warts, are common skin conditions that can be difficult to treat, especially when they recur or resist standard therapies. Isotretinoin, a medication traditionally used for acne, has recently shown promise as an adjuvant therapy for these conditions. This retrospective case-series study included 4 adult patients with persistent or recurrent tinea infections (tinea cruris and tinea corporis) or viral warts (genital and facial) who were treated with oral isotretinoin in addition to standard therapies. The patients\u2019 demographics, clinical presentations, treatment regimens, and responses were analyzed. All 4 patients showed significant clinical improvement after starting isotretinoin. Two patients with viral warts achieved complete clearance, and two patients with tinea infections experienced notable improvement. No severe side effects were reported. This case series suggests that isotretinoin may be a promising adjunctive therapy for patients with persistent or recurrent tinea infections and viral warts. However, further quantitative controlled studies are needed to confirm these findings and establish optimal treatment protocols. This study provides preliminary evidence for the potential benefit of using isotretinoin as an adjunctive therapy for recalcitrant tinea infections and viral warts. Further research is warranted to explore its efficacy and safety in larger populations.<\/jats:p>","DOI":"10.4081\/dr.2025.10075","type":"journal-article","created":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T07:27:33Z","timestamp":1754033253000},"source":"Crossref","is-referenced-by-count":0,"title":["Oral isotretinoin for the treatment of dermatologic conditions other than acne: a case series"],"prefix":"10.4081","volume":"18","author":[{"given":"Abdulrahman","family":"Janahi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Alsannaa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahraa","family":"Abdulla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saad","family":"Alotaibi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ameen","family":"Alawadhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jawaher","family":"Aljalahma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2549","published-online":{"date-parts":[[2025,8,1]]},"reference":[{"key":"40749","doi-asserted-by":"crossref","unstructured":"1. White TC, Findley K, Dawson TL, et al. Fungi on the Skin: Dermatophytes and Malassezia. Cold Spring Harb Perspect Med 2014;4.","DOI":"10.1101\/cshperspect.a019802"},{"key":"40750","doi-asserted-by":"crossref","unstructured":"2. Mahajan R, Sahoo A. Management of tinea corporis, tinea cruris, and tinea pedis: A comprehensive review. Indian Dermatol Online J 2016;7:77-86.","DOI":"10.4103\/2229-5178.178099"},{"key":"40751","doi-asserted-by":"crossref","unstructured":"3. Gnat S, \u0141agowski D, Nowakiewicz A. Genetic Predisposition and its Heredity in the Context of Increased Prevalence of Dermatophytoses. Mycopathologia 2021;186:163-76.","DOI":"10.1007\/s11046-021-00529-1"},{"key":"40752","unstructured":"4. Rahman M. Role of Itraconazole Pulse Therapy with Adjuvant Isotretinoin in treating Recurrent and Recalcitrant Dermatophytosis. Gulf J Dermatol Venereol 2019;26:11-4."},{"key":"40753","doi-asserted-by":"crossref","unstructured":"5. Srivastava A, Kothiwala S. Isotretinoin may affect pharmacokinetics of itraconazole in the skin: is it rational to combine both for the treatment of dermatophytosis? Indian J Dermatol Venereol Leprol 2017;83:68-9.","DOI":"10.4103\/0378-6323.194292"},{"key":"40754","doi-asserted-by":"crossref","unstructured":"6. Alhamdi D, Alhamdi K. Efficacy and safety of adding low-dose isotretinoin to itraconazole in the treatment of chronic recurrent dermatophytosis among a sample of Iraqi patients: an open-labelled therapeutic clinical comparative study. Indian Dermatol Online J 2022;67:624.","DOI":"10.4103\/ijd.ijd_332_22"},{"key":"40755","doi-asserted-by":"crossref","unstructured":"7. Ringin S. The effectiveness of cutaneous wart resolution with current treatment modalities. J Cutan Aesthet Surg 2020; 13:24-30.","DOI":"10.4103\/JCAS.JCAS_62_19"},{"key":"40756","doi-asserted-by":"crossref","unstructured":"8. Abd-Elazeim FM, Mohammed GF, Fathy A, Mohamed RW. Evaluation of IL-12 serum level in patients with recalcitrant multiple common warts, treated by intralesional tuberculin antigen. J Dermatolog Treat 2014;25:264-7.","DOI":"10.3109\/09546634.2013.768760"},{"key":"40757","doi-asserted-by":"crossref","unstructured":"9. Sivasankari M, Adityan M. Oral isotretinoin as first-line systemic therapy in a case of extensive genital warts. Indian J Sex Transm Dis AIDS 2022;43:70-2.","DOI":"10.4103\/ijstd.ijstd_121_20"},{"key":"40758","doi-asserted-by":"crossref","unstructured":"10. Olguin-Garc\u00eda MG, Jurado-Santa Cruz F, Peralta-Pedrero ML, Morales-S\u00e1nchez MA. A double-blind, randomized, placebo-controlled trial of oral isotretinoin in the treatment of recalcitrant facial flat warts. J Dermatolog Treat 2015;26:78-82.","DOI":"10.3109\/09546634.2013.869302"},{"key":"40759","doi-asserted-by":"crossref","unstructured":"11. Meghana Reddy E, Rajashekar TS, Kumar KS. A comparative study of intralesional acyclovir vs immunotherapy for treatment of viral warts. Cur\u0113us (Palo Alto, CA) 2023;15.","DOI":"10.7759\/cureus.38781"},{"key":"40760","doi-asserted-by":"crossref","unstructured":"12. Al-Hamamy HR, Salman HA, Abdulsattar NA. Treatment of plane warts with a low-dose oral isotretinoin. ISRN Dermatology 2012:163929:1-3.","DOI":"10.5402\/2012\/163929"},{"key":"40761","doi-asserted-by":"crossref","unstructured":"13. Kaur GJ, Brar BK, Kumar S, et al. Evaluation of the efficacy and safety of oral isotretinoin versus topical isotretinoin in the treatment of plane warts: a randomized open trial. Int J Dermatol 2017;56:1352-8.","DOI":"10.1111\/ijd.13727"},{"key":"40762","doi-asserted-by":"crossref","unstructured":"14. Chu S, Michelle L, Ekelem C, et al. Oral isotretinoin for the treatment of dermatologic conditions other than acne: a systematic review and discussion of future directions. Arch Dermatol Res 2021;313:391-430.","DOI":"10.1007\/s00403-020-02152-4"},{"key":"40763","doi-asserted-by":"crossref","unstructured":"15. Keshwania P, Kaur N, Chauhan J, et al. Superficial Dermatophytosis across the World\u2019s Populations: Potential Benefits from Nanocarrier-Based Therapies and Rising Challenges. ACS Omega 2023;8:31575-99.","DOI":"10.1021\/acsomega.3c01988"},{"key":"40764","doi-asserted-by":"crossref","unstructured":"16. Singh A, Masih A, Khurana A, et al. High terbinafine resistance in Trichophyton interdigitale isolates in Delhi, India harbouring mutations in the squalene epoxidase gene. Mycoses 2018;61:477-84.","DOI":"10.1111\/myc.12772"},{"key":"40765","doi-asserted-by":"crossref","unstructured":"17. Monod M. Antifungal resistance in dermatophytes: Emerging problem and challenge for the medical community. J Mycol Med 2019;29:283-4.","DOI":"10.1016\/j.mycmed.2019.100913"},{"key":"40766","doi-asserted-by":"crossref","unstructured":"18. Das A, Sil A, Fatima F, et al. Impact of chronic and recurrent dermatophytosis on quality of life and psychologic morbidity-a cross-sectional study. J Cosmet Dermatol 2022;21:3586-92.","DOI":"10.1111\/jocd.14676"},{"key":"40767","doi-asserted-by":"crossref","unstructured":"19. Singh S, Shukla P. End of the road for terbinafine? Results of a pragmatic prospective cohort study of 500 patients. Indian J Dermatol Venereol Leprol 2018;84:554-7.","DOI":"10.4103\/ijdvl.IJDVL_526_17"},{"key":"40768","doi-asserted-by":"crossref","unstructured":"20. Ardeshna KP, Rohatgi S, Jerajani HR. Successful treatment of recurrent dermatophytosis with isotretinoin and itraconazole. 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