{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T22:35:14Z","timestamp":1789857314466,"version":"4.0.1"},"reference-count":5,"publisher":"PAGEPress Publications","issue":"2","license":[{"start":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:00:00Z","timestamp":1758067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatol Reports"],"abstract":"<jats:p>Dermatitis herpetiformis (DH) is an uncommon autoimmune blistering skin disorder linked to gluten sensitivity. This report describes the line-field confocal optical coherence tomography (LC-OCT) features in a DH case, correlating with histopathological findings. A 60-year-old man exhibited erythematous papules and vesicles on the trunk with itching and burning, alongside alternating bowel issues. LC-OCT revealed subepidermal hypo-reflective areas with hyper-reflective floating cells at the dermal papillae tips. Histopathology showed subepidermal vesiculation and neutrophilic microabscesses, confirmed by granular IgA deposits in the dermal papillae via direct immunofluorescence (DIF). The patient tested positive for anti-tissue transglutaminase antibodies, was referred to a gastroenterologist, and began dapsone treatment, resolving the skin lesions. LC-OCT findings were consistent with histopathology, supporting its utility in diagnosing DH. Despite clinical similarities between DH and other blistering disorders, LCOCT offers a non-invasive diagnostic approach, aiding in identifying optimal biopsy sites and expediting treatment. Further studies are warranted to validate LC-OCT\u2019s potential.<\/jats:p>","DOI":"10.4081\/dr.2025.10100","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T08:37:21Z","timestamp":1758098241000},"source":"Crossref","is-referenced-by-count":1,"title":["Unusual site presentation of dermatitis herpetiformis: line-field confocal optical coherence tomography for effective management"],"prefix":"10.4081","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4374-802X","authenticated-orcid":false,"given":"Luca","family":"Bettolini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2781-6909","authenticated-orcid":false,"given":"Stefano","family":"Bighetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5454-4220","authenticated-orcid":false,"given":"Sara","family":"Rovaris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iacopo","family":"Ghini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0420-5009","authenticated-orcid":false,"given":"Vincenzo","family":"Maione","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2549","published-online":{"date-parts":[[2025,9,17]]},"reference":[{"key":"41048","doi-asserted-by":"crossref","unstructured":"1. Nguyen CN, Kim SJ. Dermatitis Herpetiformis: An Update on Diagnosis, Disease Monitoring, and Management. Medicina (Kaunas) 2021;57:843.","DOI":"10.3390\/medicina57080843"},{"key":"41049","doi-asserted-by":"crossref","unstructured":"2. Tognetti L, Cinotti E, Suppa M, et al. Line field confocal optical coherence tomography: An adjunctive tool in the diagnosis of autoimmune bullous diseases. J Biophotonics 2021;14:e202000449.","DOI":"10.1002\/jbio.202000449"},{"key":"41050","doi-asserted-by":"crossref","unstructured":"3. Mandel VD, Cinotti E, Benati E, et al. Reflectance confocal microscopy and optical coherence tomography for the diagnosis of bullous pemphigoid and pemphigus and surrounding subclinical lesions. J Eur Acad Dermatol Venereol 2018;32:1562-9.","DOI":"10.1111\/jdv.14795"},{"key":"41051","doi-asserted-by":"crossref","unstructured":"4. Clarindo MV, Possebon AT, Soligo EM, et al. Dermatitis herpetiformis: pathophysiology, clinical presentation, diagnosis and treatment. An Bras Dermatol 2014;89:865-77.","DOI":"10.1590\/abd1806-4841.20142966"},{"key":"41052","doi-asserted-by":"crossref","unstructured":"5. G\u00f6r\u00f6g A, Antiga E, Caproni M, et al. S2k guidelines (consensus statement) for diagnosis and therapy of dermatitis herpetiformis initiated by the European Academy of Dermatology and Venereology (EADV). J Eur Acad Dermatol Venereol 2021;35:1251-77.","DOI":"10.1111\/jdv.17183"}],"container-title":["Dermatology Reports"],"original-title":[],"link":[{"URL":"https:\/\/journals.pagepress.net\/dr\/article\/download\/10100\/9744","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.pagepress.net\/dr\/article\/download\/10100\/9962","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.pagepress.net\/dr\/article\/download\/10100\/9744","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T08:08:20Z","timestamp":1783066100000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.pagepress.net\/dr\/article\/view\/10100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,17]]},"references-count":5,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,5,11]]}},"URL":"https:\/\/doi.org\/10.4081\/dr.2025.10100","relation":{},"ISSN":["2036-7406","2036-7392"],"issn-type":[{"value":"2036-7406","type":"electronic"},{"value":"2036-7392","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9,17]]}}}