{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T23:32:43Z","timestamp":1768433563045,"version":"3.49.0"},"reference-count":19,"publisher":"PAGEPress Publications","issue":"3","license":[{"start":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T00:00:00Z","timestamp":1738281600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatol Reports"],"abstract":"<jats:p>Bier\u2019s spots are rare angiospastic macules often associated with physiologic vasoconstriction. This case report describes a 35-year-old man with chronic myeloid leukemia (CML) treated with nilotinib who developed Bier\u2019s spots, a previously unreported adverse effect of the drug. The patient presented with asymptomatic hypopigmented macules on the hands and legs that appeared during venous stasis and resolved with elevation. This case emphasizes the need to recognize potential vascular side effects of tyrosine kinase inhibitors (TKIs) and highlights Bier\u2019s spots as a benign but remarkable manifestation in patients undergoing nilotinib therapy.<\/jats:p>","DOI":"10.4081\/dr.2025.10160","type":"journal-article","created":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T06:15:39Z","timestamp":1738304139000},"source":"Crossref","is-referenced-by-count":2,"title":["A rare vascular manifestation in chronic myeloid leukemia: a case report and literature review of Bier\u2019s spot development during nilotinib treatment"],"prefix":"10.4081","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0329-905X","authenticated-orcid":false,"given":"Ahmed","family":"Alsaati","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Turki","family":"Hakami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sultan","family":"Bajawi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gamil","family":"Mohammed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nouf","family":"Bajawi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1269-3684","authenticated-orcid":false,"given":"Nadya","family":"Al-Faraidy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2549","published-online":{"date-parts":[[2025,1,31]]},"reference":[{"key":"23359","unstructured":"Goldsmith LA, Katz SI, Gilchrest BA, et al., editors. Fitzpatrick's dermatology in general medicine, 8e. New York, NY: The McGraw-Hill Companies; 2012."},{"key":"23360","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.03.009"},{"key":"23361","unstructured":"Bolognia J, Schaffer JV, Cerroni L. Dermatology. Fourth edition ed. [Philadelphia]: Elsevier; 2018."},{"key":"23362","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.136.5.674-a"},{"key":"23363","unstructured":"Schoenlaub P, Dupr\u00e9 D, Redon JY, Plantin P. Numerous and large Bier's spot associated with pregnancy. Eur J Dermatol 1999;9:230-1."},{"key":"23364","doi-asserted-by":"publisher","DOI":"10.2217\/fon-2018-0468"},{"key":"23365","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.22037"},{"key":"23366","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.119.313353"},{"key":"23367","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2006.02298.x"},{"key":"23368","doi-asserted-by":"publisher","DOI":"10.1159\/000051655"},{"key":"23369","doi-asserted-by":"publisher","DOI":"10.17140\/TCOJ-1-102"},{"key":"23370","unstructured":"Aytekin S. Bier spots on the face: case report. 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Available from: https:\/\/www.clinicalkey.com.au\/dura\/browse\/bookChapter\/3-s2.0-C20141020972"}],"container-title":["Dermatology Reports"],"original-title":[],"link":[{"URL":"https:\/\/www.pagepress.org\/journals\/dr\/article\/download\/10160\/9561","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.pagepress.org\/journals\/dr\/article\/download\/10160\/9772","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.pagepress.org\/journals\/dr\/article\/download\/10160\/9561","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T08:40:36Z","timestamp":1760604036000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.pagepress.org\/journals\/dr\/article\/view\/10160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,31]]},"references-count":19,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,8,22]]}},"URL":"https:\/\/doi.org\/10.4081\/dr.2025.10160","relation":{},"ISSN":["2036-7406","2036-7392"],"issn-type":[{"value":"2036-7406","type":"electronic"},{"value":"2036-7392","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1,31]]}}}