{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:47:25Z","timestamp":1773103645998,"version":"3.50.1"},"reference-count":9,"publisher":"PAGEPress Publications","issue":"1","license":[{"start":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T00:00:00Z","timestamp":1747872000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatol Reports"],"abstract":"<jats:p>Acral melanoma (AM) is a rare subtype of melanoma that occurs on acral sites such as the palms, soles, and subungual regions. Due to its atypical presentation and frequent lack of pigmentation in the amelanotic variant (AAM), diagnosis is often delayed, leading to a poor prognosis. We present the case of a 69-year-old woman with a chronic nail lesion that was initially misdiagnosed as onychomycosis and treated with partial onychectomy without histological evaluation. The lesion persisted, and subsequent dermatological evaluation revealed an ulcerated exophytic mass, which was confirmed as an acral nodular melanoma with a Breslow thickness of 7.5 mm. Despite surgical amputation, the patient\u2019s management was complicated by wound infection and limited therapeutic options due to comorbidities. This case highlights the diagnostic challenges of AM and emphasizes the importance of early histopathological assessment and multidisciplinary collaboration for timely intervention and improved outcomes.<\/jats:p>","DOI":"10.4081\/dr.2025.10332","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T10:43:12Z","timestamp":1747910592000},"source":"Crossref","is-referenced-by-count":1,"title":["Diagnostic challenges and importance of early multidisciplinary intervention in acral melanoma: a case report"],"prefix":"10.4081","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5014-1122","authenticated-orcid":false,"given":"Fortunato","family":"Cassalia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Del Fiore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8656-2927","authenticated-orcid":false,"given":"Andrea","family":"Danese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Sold\u00e0","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Furfaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9433-8445","authenticated-orcid":false,"given":"Simone","family":"Mocellin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2549","published-online":{"date-parts":[[2025,5,22]]},"reference":[{"key":"36446","doi-asserted-by":"crossref","unstructured":"1. Darmawan CC, Jo G, Montenegro SE, et al. Early detection of acral melanoma: a review of clinical, dermoscopic, histopathologic, and molecular characteristics. J Am Acad Dermatol 2019;81:805-12.","DOI":"10.1016\/j.jaad.2019.01.081"},{"key":"36447","doi-asserted-by":"crossref","unstructured":"2. Gong HZ, Zheng HY, Li J. Amelanotic melanoma. Melanoma Res 2019;29:221-30.","DOI":"10.1097\/CMR.0000000000000571"},{"key":"36448","doi-asserted-by":"crossref","unstructured":"3. Cassalia F, Danese A, Cocchi E, et al. Misdiagnosis and clinical insights into acral amelanotic melanoma: a systematic review. J Pers Med 2024;14:518.","DOI":"10.3390\/jpm14050518"},{"key":"36449","doi-asserted-by":"crossref","unstructured":"4. Lezcano C, Jungbluth AA, Nehal KS, et al. PRAME expression in melanocytic tumors. Am J Surg Pathol 2018;42:1456-65.","DOI":"10.1097\/PAS.0000000000001134"},{"key":"36450","doi-asserted-by":"crossref","unstructured":"5. Cassalia F, Danese A, Tudurachi I, et al. PRAME updated: diagnostic, prognostic, and therapeutic role in skin cancer. Int J Mol Sci 2024;25:1582.","DOI":"10.3390\/ijms25031582"},{"key":"36451","doi-asserted-by":"crossref","unstructured":"6. Stagner AM, Tahan SR, Nazarian RM. Changing trends in dermatopathology case complexity: a 9-year academic center experience. Arch Pathol Lab Med 2021;145:1144-7.","DOI":"10.5858\/arpa.2020-0458-OA"},{"key":"36452","doi-asserted-by":"crossref","unstructured":"7. Guarneri C, Bevelacqua V, Semkova K, et al. Subungual acrolentiginous amelanotic melanoma treated with amputation of the distal and middle phalanges. Wien Med Wochenschr 2013;163:368-71.","DOI":"10.1007\/s10354-013-0194-4"},{"key":"36453","doi-asserted-by":"crossref","unstructured":"8. Perez M, Abisaad JA, Rojas KD, et al. Skin cancer: primary, secondary, and tertiary prevention. Part I. J Am Acad Dermatol 2022;87:255-68.","DOI":"10.1016\/j.jaad.2021.12.066"},{"key":"36454","doi-asserted-by":"crossref","unstructured":"9. Rojas KD, Perez ME, Marchetti MA, et al. Skin cancer: primary, secondary, and tertiary prevention. Part II. J Am Acad Dermatol 2022;87:271-88.","DOI":"10.1016\/j.jaad.2022.01.053"}],"container-title":["Dermatology Reports"],"original-title":[],"link":[{"URL":"https:\/\/journals.pagepress.net\/dr\/article\/download\/10332\/9666","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.pagepress.net\/dr\/article\/download\/10332\/9886","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.pagepress.net\/dr\/article\/download\/10332\/9666","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T13:46:13Z","timestamp":1773063973000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.pagepress.net\/dr\/article\/view\/10332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,22]]},"references-count":9,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,2,12]]}},"URL":"https:\/\/doi.org\/10.4081\/dr.2025.10332","relation":{},"ISSN":["2036-7406","2036-7392"],"issn-type":[{"value":"2036-7406","type":"electronic"},{"value":"2036-7392","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5,22]]}}}