{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T14:14:37Z","timestamp":1779286477757,"version":"3.51.4"},"reference-count":22,"publisher":"PAGEPress Publications","issue":"2","license":[{"start":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T00:00:00Z","timestamp":1751932800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatol Reports"],"abstract":"<jats:p>This single-arm observational study evaluated the efficacy and safety of a novel topical formulation containing a complex mixture of polyphenols (CMP) \u2013 a proprietary blend rich in oleocanthal and oleuropein aglycone (each &gt;60%), along with hydroxytyrosol and other extra virgin olive oil (EVOO)-derived polyphenols \u2013 combined with triticum vulgare germ (TVG) oil, betaine, propanediol, and tocopheryl acetate in patients with mild palmoplantar psoriasis (PPP). Twenty participants (aged 20-55) applied the formulation twice daily for 8 days, with assessments conducted on days 0 (baseline), 5, and 8. Participants underwent a 60-day follow-up to assess the durability of benefits and potential late-onset adverse events. Clinical evaluations measured lesion extent, keratinization, inflammation, desquamation, and infiltration. A patient-reported questionnaire evaluated quality of life (QoL) and symptom burden. By day 8, the mean lesion extent had decreased by approximately 40%, inflammation had improved by about 50%, and desquamation had resolved fully in most cases. Patient-reported outcomes improved alongside clinical measures. At day 60, these improvements persisted in 85% of participants, and no adverse events emerged. The formulation\u2019s mechanism of action is hypothesized to involve the concerted antioxidant and anti-inflammatory activities of polyphenols (oleocanthal, oleuropein aglycone, and hydroxytyrosol) in synergy with TVG oil\u2019s supportive lipid matrix and other excipients. These findings suggest that EVOO-derived polyphenols formulated in TVG oil may serve as a valuable adjunct for managing PPP with good tolerability and sustained benefits.<\/jats:p>","DOI":"10.4081\/dr.2025.10333","type":"journal-article","created":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T10:33:08Z","timestamp":1751970788000},"source":"Crossref","is-referenced-by-count":1,"title":["Efficacy of a topical polyphenol-based formulation in palmoplantar psoriasis: an observational study"],"prefix":"10.4081","volume":"18","author":[{"given":"Simone","family":"Amato","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annunziata","family":"Dattola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Bennardo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Tolone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven Paul","family":"Nistic\u00f2","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2549","published-online":{"date-parts":[[2025,7,8]]},"reference":[{"key":"40030","doi-asserted-by":"crossref","unstructured":"1. Chung JH, Rich P, Lee JH, et al. Palmoplantar psoriasis is associated with greater impairment of health-related quality of life compared with moderate to severe plaque psoriasis. J Am Acad Dermatol 2014;70:698-703.","DOI":"10.1016\/j.jaad.2014.04.063"},{"key":"40031","doi-asserted-by":"crossref","unstructured":"2. Colao JM, Mrowietz U, Augustin M, Reich K. Successful treatment of palmoplantar psoriasis using combination acitretin and apremilast: A case report. J Psoriasis Psoriatic Arthritis 2016;1:85-288.","DOI":"10.1177\/247553031600100203"},{"key":"40032","doi-asserted-by":"crossref","unstructured":"3. Muqrin N, AlGhamdi K, AlTarakji R, AlQahtani M. Rapid response of palmoplantar psoriasis to risankizumab: A case report. Clin Cosmet Investig Dermatol 2022;15:897-901.","DOI":"10.2147\/CCID.S384990"},{"key":"40033","doi-asserted-by":"crossref","unstructured":"4. Wang CQ, Haxhinasto S, Garcet S, et al. Comparison of the inflammatory circuits in psoriasis vulgaris, non-pustular palmoplantar psoriasis, and palmoplantar pustular psoriasis. J Invest Dermatol 2023;143:87-97.e14.","DOI":"10.1016\/j.jid.2022.05.1094"},{"key":"40034","doi-asserted-by":"crossref","unstructured":"5. Engin B, A\u015fk\u0131n \u00d6, Tu\u0308zu\u0308n Y. Palmoplantar psoriasis. Clin Dermatol 2017;35:19-27.","DOI":"10.1016\/j.clindermatol.2016.09.004"},{"key":"40035","doi-asserted-by":"crossref","unstructured":"6. Darakjian LI, Rigakou A, Brannen A, et al. Spontaneous In Vitro and In Vivo Interaction of (-)-Oleocanthal with Glycine in Biological Fluids: Novel Pharmacokinetic Markers. ACS Pharmacol Transl Sci 2021;4:179-92.","DOI":"10.1021\/acsptsci.0c00166"},{"key":"40036","doi-asserted-by":"crossref","unstructured":"7. Nistic\u00f2 SP, Greco ME, Amato S, et al. Evaluating the impact of oleocanthal and oleacein on skin aging: results of a randomized clinical study. Medicina (Kaunas) 2024;60.","DOI":"10.3390\/medicina60060947"},{"key":"40037","doi-asserted-by":"crossref","unstructured":"8. Akl M, Ayoub NM, Mohyeldin MM, et al. Olive phenolics as c-Met inhibitors: (-)-oleocanthal attenuates cell proliferation, invasiveness, and tumor growth in breast cancer models. PLoS One 2014;9:e97622.","DOI":"10.1371\/journal.pone.0097622"},{"key":"40038","doi-asserted-by":"crossref","unstructured":"9. Pei J, He Y, He T, et al. (-)-Oleocanthal inhibits growth and metastasis by blocking activation of STAT3 in human hepatocellular carcinoma. Oncotarget 2016;7:70669-82.","DOI":"10.18632\/oncotarget.9782"},{"key":"40039","doi-asserted-by":"crossref","unstructured":"10. Batarseh A, Kaddoumi A. Oleocanthal-rich extra-virgin olive oil enhances donepezil effect by reducing amyloid-\u03b2 load and related toxicity in a mouse model of Alzheimer\u2019s disease. J Nutr Biochem 2018;62:76-85.","DOI":"10.1016\/j.jnutbio.2017.12.006"},{"key":"40040","doi-asserted-by":"crossref","unstructured":"11. Ayoub N, Mohyeldin MM, Ebrahim HY, et al. The olive oil phenolic (-)-oleocanthal modulates estrogen receptor expression in luminal breast cancer in vitro and in vivo and synergizes with tamoxifen treatment. Eur J Pharmacol 2017;795:16-27.","DOI":"10.1016\/j.ejphar.2017.06.019"},{"key":"40041","doi-asserted-by":"crossref","unstructured":"12. Montoya M, Garc\u00eda JJ, Salazar R, et al. Oleocanthal modulates LPS-induced murine peritoneal macrophages activation via regulation of inflammasome, Nrf-2\/HO-1, and MAPKs signaling pathways. J Agric Food Chem 2019;67:2920-9.","DOI":"10.1021\/acs.jafc.9b00771"},{"key":"40042","doi-asserted-by":"crossref","unstructured":"13. Ruiz-Garc\u00eda J, Gonz\u00e1lez-Dom\u00ednguez R, Pascual-Vaca \u00c1, et al. Rich oleocanthal and oleacein extra virgin olive oil and inflammatory and antioxidant status in people with obesity and prediabetes. The APRIL Study: a randomised, controlled crossover study. Preprints 2023.","DOI":"10.1016\/j.clnu.2023.06.027"},{"key":"40043","doi-asserted-by":"crossref","unstructured":"14. Iacono F, Ferrara L, Ferraraccio F, et al. Effect of oleocanthal and its derivatives on inflammatory response induced by lipopolysaccharide in a murine chondrocyte cell line. Arthritis Rheumatol 2010;62:3824-32.","DOI":"10.1002\/art.27437"},{"key":"40044","unstructured":"15. Duffin K, Yeung H, Takeshita J, et al. Characterization of patients with psoriasis in challenging-to-treat body areas in the Corrona Psoriasis Registry. Dermatology 2020;236:485-90."},{"key":"40045","unstructured":"16. Rompoti N, Koutouzi K, Menexes G. Phenolic compounds: a new generation of anti-inflammatory agents. Antioxidants (Basel) 2019;8:211."},{"key":"40046","unstructured":"17. Chung KT, Wong TY, Wei CI, et al. Tannins and their biochemical properties. Crit Rev Food Sci Nutr 2014;54:153-71."},{"key":"40047","unstructured":"18. Muqrin AS, Shaikh AA, Zareef M. Formulation and evaluation of topical applications of herbal oil emulsion containing natural phenolic compounds. Cosmetics 2022;9:85."},{"key":"40048","unstructured":"19. Alajlan MM, Qadoumi MH. The role of lipid-based nanoformulations in the delivery of polyphenols. Int J Nanomedicine 2021;16:8659-82."},{"key":"40049","unstructured":"20. Zhang X, Zhang M, Zhu Q, et al. Oleocanthal and other phenolic compounds from olive oil modulate the inflammatory response in human monocytes. J Funct Foods 2019;58:117-28."},{"key":"40050","unstructured":"21. Moussa AWS, Nasr AM, Elkabarity RH, Khalil MF. The synergistic effect of olive leaf extract and vitamin E in healing cutaneous wounds: a randomized clinical trial. J Dermatol Treat 2020;31:634-41."},{"key":"40051","unstructured":"22. Watts MF, Martin KS, Brown BJ, et al. Dietary polyphenols and their role in modulating inflammatory pathways in chronic disease. 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