{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T02:41:34Z","timestamp":1778726494082,"version":"3.51.4"},"reference-count":8,"publisher":"PAGEPress Publications","issue":"4","license":[{"start":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T00:00:00Z","timestamp":1744329600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatol Reports"],"abstract":"<jats:p>Skin aging is characterized by loss of elasticity, wrinkles, and textural changes. Treatments range from non-invasive options, such as alpha-hydroxy acids and retinoic acid, to invasive procedures like chemical peels and laser therapies. Plasma radiofrequency (PRF) offers a minimally invasive solution with a favorable balance of efficacy and tolerability. This study assessed the clinical and microscopic outcomes of combining PRF ablation with a galenic cream containing 5% resorcinol in NourivanTM Antiox for facial skin aging. Forty-one patients with visible signs of aging underwent a single PRF session followed by weekly applications of a 5% resorcinol cream for six weeks. Outcomes were evaluated using digital photography and line-field confocal optical coherence tomography (LC-OCT) at baseline, three months, and six months. Primary endpoints included wrinkle reduction and texture improvement; secondary endpoints included adverse effects and patient satisfaction. At six months, 92% of patients showed significant wrinkle reduction and improved collagen organization in LC-OCT images. Skin texture improvements were reported by 85% of patients. Adverse effects, such as mild erythema and peeling, were transient and resolved without discontinuation. PRF ablation combined with 5% resorcinol cream is an effective and well-tolerated treatment for facial skin aging, offering significant improvements in skin texture and appearance. Further research is needed to confirm these findings and explore long-term effects.<\/jats:p>","DOI":"10.4081\/dr.2025.10342","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T05:59:14Z","timestamp":1744351154000},"source":"Crossref","is-referenced-by-count":1,"title":["Facial skin rejuvenation through plasma radiofrequency ablation combined with 5% resorcinol cream: clinical and line-field confocal optical coherence tomography evaluation"],"prefix":"10.4081","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2148-8914","authenticated-orcid":false,"given":"Caterina Mariarosaria","family":"Giorgio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0834-1331","authenticated-orcid":false,"given":"Gaetano","family":"Licata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0278-2443","authenticated-orcid":false,"given":"Eugenia Veronica","family":"Di Brizzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5121-1743","authenticated-orcid":false,"given":"Graziella","family":"Babino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2635-8489","authenticated-orcid":false,"given":"Elisabetta","family":"Fulgione","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5160-8997","authenticated-orcid":false,"given":"Elvira","family":"Moscarella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2912-6311","authenticated-orcid":false,"given":"Giuseppe","family":"Lodi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3103-5217","authenticated-orcid":false,"given":"Nicola Maria","family":"Giorgio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4276-0028","authenticated-orcid":false,"given":"Vittorio","family":"Tancredi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1413-8214","authenticated-orcid":false,"given":"Giuseppe","family":"Argenziano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adone","family":"Baroni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2549","published-online":{"date-parts":[[2025,4,11]]},"reference":[{"key":"33866","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12716"},{"key":"33867","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14045"},{"key":"33868","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.143.2.168"},{"key":"33869","doi-asserted-by":"publisher","DOI":"10.1111\/j.1473-2165.2008.00385.x"},{"key":"33870","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16287"},{"key":"33871","doi-asserted-by":"publisher","DOI":"10.1159\/000531926"},{"key":"33872","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12774"},{"key":"33873","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11010140"}],"container-title":["Dermatology Reports"],"original-title":[],"link":[{"URL":"https:\/\/journals.pagepress.net\/dr\/article\/download\/10342\/9638","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.pagepress.net\/dr\/article\/download\/10342\/9799","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.pagepress.net\/dr\/article\/download\/10342\/9638","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T15:32:48Z","timestamp":1764689568000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.pagepress.net\/dr\/article\/view\/10342"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,11]]},"references-count":8,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,11,5]]}},"URL":"https:\/\/doi.org\/10.4081\/dr.2025.10342","relation":{},"ISSN":["2036-7406","2036-7392"],"issn-type":[{"value":"2036-7406","type":"electronic"},{"value":"2036-7392","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4,11]]}}}