{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T20:45:24Z","timestamp":1775594724414,"version":"3.50.1"},"reference-count":10,"publisher":"PAGEPress Publications","issue":"1","license":[{"start":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T00:00:00Z","timestamp":1747267200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatol Reports"],"abstract":"<jats:p>Glomus tumors are rare, benign neoplasms arising from glomus bodies, primarily located in the subungual region and upper extremities, but uncommonly reported in areas such as the scrotum. Here, we describe a unique case of a glomus tumor of the scrotal skin in a 28-year-old male presenting with a two-year history of a painful, gradually enlarging scrotal nodule. Clinical examination revealed a tender oblong nodule, and dermoscopy suggested a benign neoplasm. Imaging and initial biopsy confirmed the lesion as a possible glomus tumor. Remarkably, during biopsy, the tumor spontaneously and completely \u201cpopped out\u201d, narrowing the differential diagnosis to glomus tumor, angiolipoma, and epidermoid cyst. Histopathology confirmed the diagnosis of a glomus tumor, showing classic features including thick-walled blood vessels surrounded by smooth muscle actin-positive cells and a pseudocapsule. Postoperative pain resolution supported the clinical diagnosis. This case highlights the importance of considering glomus tumors in the differential diagnosis of painful scrotal lesions, especially when a mass exhibits spontaneous ejection during manipulation. To our knowledge, this is the first reported case of a scrotal glomus tumor in Saudi Arabia.<\/jats:p>","DOI":"10.4081\/dr.2025.10348","type":"journal-article","created":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T03:06:53Z","timestamp":1747278413000},"source":"Crossref","is-referenced-by-count":0,"title":["Glomus tumor of the scrotum: an intraoperative differential diagnostic tip"],"prefix":"10.4081","volume":"18","author":[{"given":"Ahmed","family":"Nassar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9682-4199","authenticated-orcid":false,"given":"Mohammed","family":"Alshahrani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1576-514X","authenticated-orcid":false,"given":"Ayed","family":"Alkahtani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adel","family":"Alfaifi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mothanna","family":"Najmi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9585-4191","authenticated-orcid":false,"given":"Ahmed","family":"Almutlaq","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0831-7005","authenticated-orcid":false,"given":"Sulaiman","family":"Alfouzan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mostafa","family":"Nassar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0842-2729","authenticated-orcid":false,"given":"Esmat","family":"R. Eid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2549","published-online":{"date-parts":[[2025,5,15]]},"reference":[{"key":"38122","doi-asserted-by":"crossref","unstructured":"1. Gombos Z, Zhang PJ. Glomus tumor. Arch Pathol Lab Med 2008;132:1448-52.","DOI":"10.5858\/2008-132-1448-GT"},{"key":"38123","doi-asserted-by":"crossref","unstructured":"2. Lee W, Kwon SB, Cho SH, et al. Glomus tumor of the hand. Arch Plast Surg 2015;42:295-301.","DOI":"10.5999\/aps.2015.42.3.295"},{"key":"38124","doi-asserted-by":"crossref","unstructured":"3. Miller JA, Moxon NR, Morency EG, et al. First presentation of a scrotal glomus tumor in an adolescent male: A case report. Urol Case Rep 2020;31:101175.","DOI":"10.1016\/j.eucr.2020.101175"},{"key":"38125","doi-asserted-by":"crossref","unstructured":"4. Carroll RE, Berman AT. Glomus tumors of the hand: review of the literature and report on twenty-eight cases. J Bone Joint Surg Am 1972;54:691-703.","DOI":"10.2106\/00004623-197254040-00001"},{"key":"38126","doi-asserted-by":"crossref","unstructured":"5. Netscher DT, Aburto J, Koepplinger M. Subungual glomus tumor. J Hand Surg Am 2012;37:821-3; quiz 824.","DOI":"10.1016\/j.jhsa.2011.10.026"},{"key":"38127","doi-asserted-by":"crossref","unstructured":"6. Tang CY, Tipoe T, Fung B. Where is the Lesion? Glomus Tumours of the Hand. Arch Plast Surg 2013;40:492-5.","DOI":"10.5999\/aps.2013.40.5.492"},{"key":"38128","doi-asserted-by":"crossref","unstructured":"7. Stewart DR, Sloan JL, Yao L, et al. Diagnosis, management, and complications of glomus tumours of the digits in neurofibromatosis type 1. J Med Genet 2010;47:525-32.","DOI":"10.1136\/jmg.2009.073965"},{"key":"38129","doi-asserted-by":"crossref","unstructured":"8. Chun JS, Hong R, Kim JA. Extradigital glomus tumor: A case report. Mol Clin Oncol 2014;2:237-9.","DOI":"10.3892\/mco.2013.219"},{"key":"38130","doi-asserted-by":"crossref","unstructured":"9. Macharia C, Nthumba PM. Glomus tumor presenting as complex regional pain syndrome of the left upper limb: a case report. J Med Case Rep 2015;9:293.","DOI":"10.1186\/s13256-015-0793-3"},{"key":"38131","doi-asserted-by":"crossref","unstructured":"10. AlNuaim B, Binsulaiman N, Alkohlani, et al. Diagnosis of glomus tumor of the elbow: A case report. 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