{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:03:04Z","timestamp":1790769784888,"version":"4.1.0"},"reference-count":16,"publisher":"PAGEPress Publications","issue":"3","license":[{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatol Reports"],"abstract":"<jats:p>Melanoma is a neoplasm with a heterogeneous clinical presentation and several histopathological variants have been described. Although histopathological evaluation remains the diagnostic gold standard, unusual morphology of some melanomas can lead to pathologic misinterpretation, as they can be confused with other non-melanocytic tumors. Here, we present a case of nodular melanoma with pseudovascular morphology characterized by uncommon empty branching slit-like spaces, reminiscent of rete testis vessels, for which we suggest the name of retiform melanoma to distinguish it from angiomatoid melanoma. Immunohistochemical analysis and ancillary molecular tests helped us characterizing this neoplasm, underscoring the need for clinical-morphological-molecular correlation for the correct diagnosis of unusual cases.<\/jats:p>","DOI":"10.4081\/dr.2025.10415","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T15:32:55Z","timestamp":1763566375000},"source":"Crossref","is-referenced-by-count":1,"title":["Primary malignant melanoma with pseudovascular morphology: a diagnostic pitfall"],"prefix":"10.4081","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3881-8540","authenticated-orcid":false,"given":"Monia","family":"Di Prete","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2788-6024","authenticated-orcid":false,"given":"Paola","family":"Pasquini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Melucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviana","family":"Lora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Cota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2549","published-online":{"date-parts":[[2025,11,19]]},"reference":[{"key":"43477","doi-asserted-by":"crossref","unstructured":"1. Brenn T. Pitfalls in the evaluation of melanocytic lesions. Histopathology 2012;60:690-705.","DOI":"10.1111\/j.1365-2559.2011.04042.x"},{"key":"43478","doi-asserted-by":"crossref","unstructured":"2. Brenn T. Melanocytic lesions - Staying out of trouble. Ann Diagn Pathol 2018;37:91-102.","DOI":"10.1016\/j.anndiagpath.2018.09.010"},{"key":"43479","doi-asserted-by":"crossref","unstructured":"3. Machado I, Llombart B, Cruz J, et al. Desmoplastic melanoma may mimic a cutaneous peripheral nerve sheath tumor: Report of 3 challenging cases. J Cutan Pathol 2017;44:632-8.","DOI":"10.1111\/cup.12949"},{"key":"43480","doi-asserted-by":"crossref","unstructured":"4. Cancer Genome Atlas Network. Genomic classification of cutaneous melanoma. Cell 2015;161:1681-96.","DOI":"10.1016\/j.cell.2015.05.044"},{"key":"43481","doi-asserted-by":"crossref","unstructured":"5. Cota C, Saggini A, Lora V, et al. Uncommon Histopathological Variants of Malignant Melanoma: Part 1. 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Flucke U, Vogels RJ, de Saint Aubain Somerhausen N, et al. Epithelioid Hemangioendothelioma: clinicopathologic, immunohistochemical, and molecular genetic analysis of 39 cases. Diagn Pathol 2014;9:131.","DOI":"10.1186\/1746-1596-9-131"},{"key":"43490","doi-asserted-by":"crossref","unstructured":"14. Randic T, Kozar I, Margue C, et al. NRAS mutant melanoma: Towards better therapies. Cancer Treat Rev 2021;99:102238.","DOI":"10.1016\/j.ctrv.2021.102238"},{"key":"43491","doi-asserted-by":"crossref","unstructured":"15. Garcia-Alvarez A, Ortiz C, Mu\u00f1oz-Couselo E. Current Perspectives and Novel Strategies of NRAS-Mutant Melanoma. Onco Targets Ther 2021;14:3709-19.","DOI":"10.2147\/OTT.S278095"},{"key":"43492","doi-asserted-by":"crossref","unstructured":"16. Kilsdonk MJ, Romeijn TR, Kelder W, et al. Angiosarcomatous transdifferentiation of metastatic melanoma. 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