{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:55:32Z","timestamp":1791276932171,"version":"4.1.0"},"reference-count":10,"publisher":"PAGEPress Publications","issue":"3","license":[{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatol Reports"],"abstract":"<jats:p>Dear Editor,\nSyphilis, the \u201cgreat mimicker\u201d, remains a diagnostic challenge despite reliable serologic assays and updated management guidelines. Its wide variety of clinical and dermatological manifestations often leads to misdiagnosis, especially when lesions are atypical. We present a case in which secondary syphilis was diagnosed through an inverted pathway, with histopathology preceding clinical suspicion and serologic confirmation. [...]<\/jats:p>","DOI":"10.4081\/dr.2025.10577","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T10:59:00Z","timestamp":1763377140000},"source":"Crossref","is-referenced-by-count":0,"title":["Syphilis, the great mimicker: an inverted diagnostic pathway that still hits the mark"],"prefix":"10.4081","volume":"18","author":[{"given":"Barbara","family":"Cocuroccia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Passarelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enzo","family":"Palese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Latini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Di Tullio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filomena","family":"Russo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2549","published-online":{"date-parts":[[2025,11,17]]},"reference":[{"key":"43871","doi-asserted-by":"crossref","unstructured":"1. Rosset F, Celoria V, Delmonte S, et al. The epidemiology of syphilis worldwide in the last decade. J Clin Med 2025;14:5308.","DOI":"10.3390\/jcm14155308"},{"key":"43872","doi-asserted-by":"crossref","unstructured":"2. Ciccarese G, Facciorusso A, Mastrolonardo M, et al. Atypical Manifestations of Syphilis: A 10-Year Retrospective Study. J Clin Med 2024;13:1603.","DOI":"10.3390\/jcm13061603"},{"key":"43873","doi-asserted-by":"crossref","unstructured":"3. Janier M, Unemo M, Dupin N, et al. 2020 European guideline on the management of syphilis. J Eur Acad Dermatol Venereol 2021;35:574-88.","DOI":"10.1111\/jdv.16946"},{"key":"43874","doi-asserted-by":"crossref","unstructured":"4. Liu XK, Li J. Histologic Features of Secondary Syphilis. Dermatology 2020;236:145-50.","DOI":"10.1159\/000502641"},{"key":"43875","doi-asserted-by":"crossref","unstructured":"5. Pourang A, Fung MA, Tartar D, Brassard A. Condyloma lata in secondary syphilis. 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Optimization strategies for HIV, hepatitis and syphilis testing in Infectious Disease Clinic and Dermatology Unit of Modena: 7-year results of collaboration experience. J Eur Acad Dermatol Venereol 2019;33:959-65.","DOI":"10.1111\/jdv.15390"},{"key":"43880","unstructured":"10. European Centre for Disease Prevention and Control. Syphilis. In: ECDC. Annual Epidemiological Report for 2023. ECDC;2025."}],"container-title":["Dermatology Reports"],"original-title":[],"link":[{"URL":"https:\/\/journals.pagepress.net\/dr\/article\/download\/10577\/9796","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.pagepress.net\/dr\/article\/download\/10577\/10099","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.pagepress.net\/dr\/article\/download\/10577\/9796","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:44:52Z","timestamp":1791276292000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.pagepress.net\/dr\/article\/view\/10577"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,17]]},"references-count":10,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,9,1]]}},"URL":"https:\/\/doi.org\/10.4081\/dr.2025.10577","relation":{},"ISSN":["2036-7406","2036-7392"],"issn-type":[{"value":"2036-7406","type":"electronic"},{"value":"2036-7392","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11,17]]}}}