{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T18:11:54Z","timestamp":1789668714215,"version":"4.0.1"},"reference-count":14,"publisher":"PAGEPress Publications","issue":"3","license":[{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatol Reports"],"abstract":"<jats:p>Fahr\u2019s syndrome is a rare entity characterized by symmetrical and bilateral non-atherosclerotic intracerebral calcifications in the basal ganglia. This entity is usually asymptomatic or may present mainly with neuro-neuropsychiatric and dermatological manifestations. Secondary bilateral striopallidodentate calcinosis (BSPDC) presentations are associated with various diseases. We describe a case of psoriasis vulgaris associated with secondary BSPDC due to hypoparathyroidism. Laboratory tests revealed hypocalcemia, hyperphosphatemia, and a low parathormone serum level; on cerebral computed tomography (CT), bilateral basal ganglia calcification was observed. Correction of calcium deficiency restored the calcium-phosphate balance and led to an improvement in psoriatic lesions. Psoriasis vulgaris is a common condition that may be associated with disturbances in calcium metabolism. Dermatologists should be aware that investigating cases resistant to conventional therapies can uncover underlying systemic disorders that significantly affect patients\u2019 quality of life.<\/jats:p>","DOI":"10.4081\/dr.2025.10614","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T08:50:11Z","timestamp":1761641411000},"source":"Crossref","is-referenced-by-count":0,"title":["The role of calcium serum level in clinical manifestation and progress of psoriasis vulgaris in a patient with Fahr\u2019s syndrome"],"prefix":"10.4081","volume":"18","author":[{"given":"Migena","family":"Vargu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabina","family":"Dedej","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petrit","family":"Vargu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eriselda","family":"Kurushi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anxhela","family":"Nisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuele","family":"Vargu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2549","published-online":{"date-parts":[[2025,10,28]]},"reference":[{"key":"43156","doi-asserted-by":"crossref","unstructured":"1. Pereira GS, Ferreira A, Castro L, et al. From cranial nerve palsy to seizures\u2014All the signs that lead to secondary Fahr\u2019s syndrome. Clin Case Rep 2021;9:e03669.","DOI":"10.1002\/ccr3.3669"},{"key":"43157","doi-asserted-by":"crossref","unstructured":"2. Marinkovi\u0107 DM, Dragovi\u0107 T, Kikovi\u0107 S, et al. Fahr\u2019s syndrome and idiopathic hypoparathyroidism \u2013 A case report. Vojnosanit Pregl 2017;74:184-8.","DOI":"10.2298\/VSP150916109M"},{"key":"43158","doi-asserted-by":"crossref","unstructured":"3. Eaton LM, Camp JD, Lore JG. Symmetric cerebral calcification, particularly of basal ganglia, demonstrable roentgen no graphically; calcification of the finer cerebral blood vessels. Arch Neurol Psychiatr 1939;41:921-42.","DOI":"10.1001\/archneurpsyc.1939.02270170059003"},{"key":"43159","doi-asserted-by":"crossref","unstructured":"4. Arruda ACG, Guerra ACDZ, Pessoa CH, et al. Hypoparathyroidism and Fahr\u2019s syndrome: case series. J Bras Nefrol 2022;44:592-6.","DOI":"10.1590\/2175-8239-jbn-2020-0243"},{"key":"43160","doi-asserted-by":"crossref","unstructured":"5. Braun GS, Witt M, Mayer V, Schmid H. Hypercalcemia caused by vitamin D3 analogs in psoriasis treatment. Int J Dermatol 2007;46:1315-7.","DOI":"10.1111\/j.1365-4632.2007.03347.x"},{"key":"43161","doi-asserted-by":"crossref","unstructured":"6. Donzuso G, Mostile G, Nicoletti A, Zappia M. Basal ganglia calcifications (Fahr\u2019s syndrome): related conditions and clinical features. Neurol Sci 2019;40:2251-63.","DOI":"10.1007\/s10072-019-03998-x"},{"key":"43162","unstructured":"7. Benkirane S, Ziani J, Chhiti S, et al. Fahr Syndrome Secondary to Hypoparathyroidism with Dermatological Revelation. Dermatol Case Rep 2020;5:160."},{"key":"43163","doi-asserted-by":"crossref","unstructured":"8. Lazara N, El Azizi L, Salhi Pr H, Ouahabib H. Syndrome de Fahr r\u00e9v\u00e9l\u00e9 par un psoriasis. Ann Endocrinol (Paris) 2020;81:367-83.","DOI":"10.1016\/j.ando.2020.07.657"},{"key":"43164","doi-asserted-by":"crossref","unstructured":"9. Shahriari M, Kerr PE, Slade K, Grant-Kels JE. Vitamin D and the skin. Clin Dermatol 2010;28:663-8.","DOI":"10.1016\/j.clindermatol.2010.03.030"},{"key":"43165","unstructured":"10. Lebwohl M, Menter A, Weiss J, et al. Calcitriol 3 microg\/g ointment in the management of mild to moderate plaque type psoriasis: results from 2 placebo-controlled, multicenter, randomized double-blind, clinical studies. J Drugs Dermatol 2007;6:428-35."},{"key":"43166","doi-asserted-by":"crossref","unstructured":"11. Noborio R, Kobayashi K, Shintani Y, Morita A. Comparison of the efficacy of calcipotriol and maxacalcitol in combination with narrow-band ultraviolet B therapy for the treatment of psoriasis vulgaris. Photodermatol Photoimmunol Photomed 2006;22:262-4.","DOI":"10.1111\/j.1600-0781.2006.00247.x"},{"key":"43167","doi-asserted-by":"crossref","unstructured":"12. Plavina T, Hincapie M, Wakshull E, et al. Increased plasma concentrations of cytoskeletal and Ca2+-binding proteins and their peptides in psoriasis patients. Clin Chem 2008;54:1805-14.","DOI":"10.1373\/clinchem.2008.103770"},{"key":"43168","doi-asserted-by":"crossref","unstructured":"13. Tissier M, Abou Nakad S, Vignon-Pennamen MD, et al. Severe hypocalcaemia-related pustular psoriasis in an 83-year-old woman with Fahr\u2019s syndrome: a case report. J Eur Acad Dermatol Venereol 2019;33:e42-3.","DOI":"10.1111\/jdv.15158"},{"key":"43169","doi-asserted-by":"crossref","unstructured":"14. Tai XY, Batla A. Fahr\u2019s disease: current perspectives. 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