{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T15:04:53Z","timestamp":1780585493806,"version":"3.54.1"},"reference-count":10,"publisher":"PAGEPress Publications","license":[{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatol Reports"],"abstract":"<jats:p>Dear Editor,\nTargeted therapies for melanoma play a pivotal role in the management of patients with advanced BRAF-mutated disease. Despite their efficacy, these treatments are associated with a spectrum of adverse events, particularly cutaneous toxicities, including photo-aggravated eruptions, increased risk of non-melanoma skin cancers, and other less frequent manifestations. Herein, we describe a clinical case and briefly review a rare and likely under-recognized adverse event: erythema nodosum (EN)-like panniculitis during BRAF inhibitor therapy. [...]<\/jats:p>","DOI":"10.4081\/dr.2026.10380","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T14:17:50Z","timestamp":1780582670000},"source":"Crossref","is-referenced-by-count":0,"title":["Erythema nodosum-like panniculitis during BRAF inhibitor therapy for melanoma: never forget latent tuberculosis infection"],"prefix":"10.4081","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2827-409X","authenticated-orcid":false,"given":"Alba","family":"Guglielmo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"D'Al\u00ec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Ludovica","family":"Deotto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Cimadamore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetano","family":"Pascoletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Poletto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Minisini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2549","published-online":{"date-parts":[[2026,6,4]]},"reference":[{"key":"40616","doi-asserted-by":"crossref","unstructured":"1. Lantto R, Jokelainen J, Huilaja L, Sinikumpu SP. Erythema nodosum in northern Finland between 1996 and 2019: A register-based study. J Dermatol 2024;51:1017-21.","DOI":"10.1111\/1346-8138.17264"},{"key":"40617","doi-asserted-by":"crossref","unstructured":"2. Bardazzi F, Loi C, Clarizio G, et al. Erythema nodosum: a clinical manifestation of Neisseria gonorrhoeae infection. Int J Dermatol 2022;61:e306-7.","DOI":"10.1111\/ijd.15957"},{"key":"40618","doi-asserted-by":"crossref","unstructured":"3. Maglie R, Genovese G, Solimani F, et al. Immune-Mediated Dermatoses in Patients with Haematological Malignancies: A Comprehensive Review. Am J Clin Dermatol 2020;21:833-54.","DOI":"10.1007\/s40257-020-00553-9"},{"key":"40619","doi-asserted-by":"crossref","unstructured":"4. M\u00f6ssner R, Zimmer L, Berking C, et al. Erythema nodosum-like lesions during BRAF inhibitor therapy: Report on 16 new cases and review of the literature. J Eur Acad Dermatol Venereol 2015;29:1797-806.","DOI":"10.1111\/jdv.13039"},{"key":"40620","doi-asserted-by":"crossref","unstructured":"5. Kye Y, Zhao G, Guhan S, et al. Research letter: BRAF-inhibitor induced panniculitis - A systematic review. J Am Acad Dermatol 2024;90:420-3.","DOI":"10.1016\/j.jaad.2023.10.008"},{"key":"40621","doi-asserted-by":"crossref","unstructured":"6. Requena L, Yus ES. Panniculitis. Part I. Mostly septal panniculitis. J Am Acad Dermatol 2001;45:163-83.","DOI":"10.1067\/mjd.2001.114736"},{"key":"40622","doi-asserted-by":"crossref","unstructured":"7. Boonchai W, Suthipinittharm P, Mahaisavariya P. Panniculitis in tuberculosis: a clinicopathologic study of nodular panniculitis associated with tuberculosis. Int J Dermatol 1998;37:361-3.","DOI":"10.1046\/j.1365-4362.1998.00299.x"},{"key":"40623","doi-asserted-by":"crossref","unstructured":"8. Kim KS, Kim JS, Kim SS, Kim CW. Association between erythema nodosum\/erythema induratum of Bazin and Mycobacterium tuberculosis infection in Koreans. Indian J Dermatol Venereol Leprol 2021;1-5.","DOI":"10.25259\/IJDVL_958_18"},{"key":"40624","doi-asserted-by":"crossref","unstructured":"9. Seban RD, Vermersch C, Champion L, et al. Immune-Related Erythema Nodosum Mimicking in Transit Melanoma Metastasis on [18F]-FDG PET\/CT. Diagnostics 2021;11:747.","DOI":"10.3390\/diagnostics11050747"},{"key":"40625","doi-asserted-by":"crossref","unstructured":"10. Ben-Betzalel G, Baruch EN, Boursi B, et al. Possible immune adverse events as predictors of durable response to BRAF inhibitors in patients with BRAF V600-mutant metastatic melanoma. Eur J Cancer Oxf Engl 1990 2018;101:229-35.","DOI":"10.1016\/j.ejca.2018.06.030"}],"container-title":["Dermatology Reports"],"original-title":[],"link":[{"URL":"https:\/\/journals.pagepress.net\/dr\/article\/download\/10380\/9946","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.pagepress.net\/dr\/article\/download\/10380\/9946","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T14:17:58Z","timestamp":1780582678000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.pagepress.net\/dr\/article\/view\/10380"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,4]]},"references-count":10,"URL":"https:\/\/doi.org\/10.4081\/dr.2026.10380","relation":{},"ISSN":["2036-7406","2036-7392"],"issn-type":[{"value":"2036-7406","type":"electronic"},{"value":"2036-7392","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6,4]]}}}