{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T11:52:09Z","timestamp":1782301929386,"version":"3.54.5"},"reference-count":15,"publisher":"PAGEPress Publications","license":[{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatol Reports"],"abstract":"<jats:p>Xerosis is a prevalent skin disorder among patients with chronic kidney disease (CKD) undergoing hemodialysis (HD). While both Aloe vera cream 30% and urea cream 20% have been shown to improve skin hydration in cases of xerosis cutis, direct comparisons between the two are limited. This study aims to compare the effectiveness of both creams in treating xerosis cutis in patients with chronic kidney disease on hemodialysis (CKD-HD). A randomized controlled trial was conducted involving 35 eligible CKD-HD patients. Each patient received either urea cream 20% or A. vera cream 30%, which was applied to both their left and right arms. Skin moisture was assessed weekly using corneometer readings and overall dry skin (ODS) scores over 4 weeks. The present study reveals that both treatments significantly increased corneometer readings and decreased ODS scores compared to baseline (p&lt;0.05), but no significant difference was found between the two creams (p&gt;0.05). In conclusion, A. vera cream 30% and urea cream 20% demonstrate similar effectiveness in improving skin moisture for patients with xerosis cutis associated with CKD-HD.<\/jats:p>","DOI":"10.4081\/dr.2026.10496","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T11:38:14Z","timestamp":1782301094000},"source":"Crossref","is-referenced-by-count":0,"title":["Comparison of the effectiveness of 30% &lt;i&gt;Aloe vera&lt;\/i&gt; cream and 20% urea cream as topical treatment for xerosis cutis in chronic kidney disease: a randomized clinical trial"],"prefix":"10.4081","author":[{"given":"Nur Hikmah","family":"Fajriani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khairuddin","family":"Djawad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farida","family":"Tabri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andi Alfian","family":"Zainuddin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haerani","family":"Rasyid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Widya","family":"Widita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2549","published-online":{"date-parts":[[2026,6,24]]},"reference":[{"key":"41100","doi-asserted-by":"crossref","unstructured":"1. Agarwal A, Nath KA. Pathophysiology of Chronic Kidney Disease Progression: Organ and Cellular Considerations. In Chronic Renal Disease. Elsevier; 2019, p. 263-78.","DOI":"10.1016\/B978-0-12-815876-0.00018-8"},{"key":"41101","doi-asserted-by":"crossref","unstructured":"2. Amin R, Lechner A, Vogt A, et al. Molecular characterization of xerosis cutis: A systematic review. PLoS One 2021;16:e0261253.","DOI":"10.1371\/journal.pone.0261253"},{"key":"41102","doi-asserted-by":"crossref","unstructured":"3. Augustin M, Wilsmann\u2010Theis D, K\u00f6rber A, et al. Diagnosis and treatment of xerosis cutis \u2013 a position paper. Dtsch Dermatol Ges 2019;17:3-33.","DOI":"10.1111\/ddg.13906"},{"key":"41103","doi-asserted-by":"crossref","unstructured":"4. Khanna D, Singal A, Kalra OP. Comparison of cutaneous manifestations in chronic kidney disease with or without dialysis. Postgrad Med J 2010;86:641-7.","DOI":"10.1136\/pgmj.2009.095745"},{"key":"41104","doi-asserted-by":"crossref","unstructured":"5. Chanda GM, Chintagunta SR, Arakkal G. Dermatological manifestations in chronic renal failure patients with and without hemodialysis: A study at a tertiary care centre. J Dr YSR Univ Health Sci 2017;6:8.","DOI":"10.4103\/JDRNTRUHS.JDRNTRUHS_53_16"},{"key":"41105","unstructured":"6. Falodun O, Ogunbiyi A, Salako B, George AK. Skin changes in patients with chronic renal failure. Saudi J Kidney Dis Transpl 2011;22:268-72."},{"key":"41106","doi-asserted-by":"crossref","unstructured":"7. Matei CE, Visan AI, Cristescu R. Aloe Vera Polysaccharides as Therapeutic Agents: Benefits Versus Side Effects in Biomedical Applications. Polysaccharides 2025;6:36.","DOI":"10.3390\/polysaccharides6020036"},{"key":"41107","doi-asserted-by":"crossref","unstructured":"8. Piquero-Casals J, Morgado-Carrasco D, Granger C, et al. Urea in Dermatology: A Review of its Emollient, Moisturizing, Keratolytic, Skin Barrier Enhancing and Antimicrobial Properties. Dermatol Ther 2021;11:1905-15.","DOI":"10.1007\/s13555-021-00611-y"},{"key":"41108","unstructured":"9. Bianti M. Kulit Kering pada Usia Lanjut [Dry Skin in the Elderly]. Cermin Dunia Kedokteran 2016;43:400114."},{"key":"41109","doi-asserted-by":"crossref","unstructured":"10. Lacy F, Ziemer C. Xerosis Cutis in the Aging Population: an Approach to Diagnosis and Treatment. Curr Geriatr Rep 2020;9:206-9.","DOI":"10.1007\/s13670-020-00333-7"},{"key":"41110","doi-asserted-by":"crossref","unstructured":"11. Polena H, Chavagnac-Bonneville M, Sayag M. Improvement of Quality of Life in Dialysis and Diabetic Patients by Skin Dryness and Pruritus Management with an Ecobiological Dermo-Cosmetic Product. Clin Cosmet Investig Dermatol 2022;15:2143-52.","DOI":"10.2147\/CCID.S375472"},{"key":"41111","unstructured":"12. Yahya YF, Roiana N, Andarina R, et al. Efficacy of 20% urea cream on uremic pruritus with uremic xerosis in chronic renal failure patients undergoing hemodialysis. Berkala Ilmu Kesehat Kulit Kelamin 2018;30:1-9."},{"key":"41112","unstructured":"13. Castello M, Milani M. Efficacy of topical hydrating and emollient lotion containing 10% urea ISDIN\u00ae plus dexpanthenol (Ureadin Rx 10) in the treatment of skin xerosis and pruritus in hemodialyzed patients: An open prospective pilot trial. G Ital Dermatol Venereol 2011;146:321-5."},{"key":"41113","doi-asserted-by":"crossref","unstructured":"14. Baalham P, Birch I, Young M, Beale C. Xerosis of the feet: a Title comparative two-deck study on the effectiveness of two moisturizers. Br J Community Nurs 2011;16:591-7.","DOI":"10.12968\/bjcn.2011.16.12.591"},{"key":"41114","doi-asserted-by":"crossref","unstructured":"15. Handriani R, Agustina W. Aloe Vera Extract 75% Effective in Providing Xerosis Repair In Chronic Kidney Failure Patients. J Ners Midwifery 2020;7:415-20.","DOI":"10.26699\/jnk.v7i3.ART.p415-420"}],"container-title":["Dermatology Reports"],"original-title":[],"link":[{"URL":"https:\/\/journals.pagepress.net\/dr\/article\/download\/10496\/9956","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.pagepress.net\/dr\/article\/download\/10496\/9956","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T11:38:46Z","timestamp":1782301126000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.pagepress.net\/dr\/article\/view\/10496"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,24]]},"references-count":15,"URL":"https:\/\/doi.org\/10.4081\/dr.2026.10496","relation":{},"ISSN":["2036-7406","2036-7392"],"issn-type":[{"value":"2036-7406","type":"electronic"},{"value":"2036-7392","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6,24]]}}}