{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T14:03:54Z","timestamp":1784642634619,"version":"3.55.0"},"reference-count":17,"publisher":"PAGEPress Publications","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatol Reports"],"abstract":"<jats:p>Actinic keratosis (AK) is a common skin disorder resulting from chronic sun exposure, which can be treated with various treatment modalities, including ablative CO2 laser. Dermoscopic evaluation is fundamental in diagnosis and post-procedural follow-up. This study aimed to achieve radical clearance of AK cancerization fields through a combined approach using an ablative CO2 laser and intra-procedural dermoscopy, rather than a pre- and post-procedural approach only. Twenty patients with 25 AKs were included in the study. Treatment with ablative CO2 laser through a dermoscopic intra-procedural approach was performed for every patient with Olsen grade I or II AK. The results of this study showed that 100% of patients treated with this method achieved clinical clearance at follow-up, and 92% had no clinical recurrence after 2 months. The intra-procedural dermoscopic approach demonstrated to be useful to extend laser ablation to the AK cancerization field. According to the results of our study and after a comprehensive literature review, we conclude that intra-procedural dermatoscopy combined with ablative CO2 laser therapy can be considered a valid alternative to CO2 laser therapy alone.<\/jats:p>","DOI":"10.4081\/dr.2026.10638","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T13:30:22Z","timestamp":1784640622000},"source":"Crossref","is-referenced-by-count":0,"title":["Could an intra-procedural dermoscopic approach be necessary for obtaining radical treatment of actinic keratosis cancerization field if combined with ablative CO&lt;sub&gt;2&lt;\/sub&gt; laser?"],"prefix":"10.4081","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8966-1064","authenticated-orcid":false,"given":"Pietro Pasquale","family":"Cozza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Bennardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven Paul","family":"Nistic\u00f2","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Marcasciano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Tammaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonino","family":"De Caridi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Zappia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Falcomat\u00e0","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2549","published-online":{"date-parts":[[2026,7,21]]},"reference":[{"key":"42010","doi-asserted-by":"crossref","unstructured":"1. Olsen EA, Abernethy ML, Kulp-Shorten C, et al. A double-blind, vehicle-controlled study evaluating masoprocol cream in the treatment of actinic keratoses on the head and neck. J Am Acad Dermatol 1991;24:738-43.","DOI":"10.1016\/0190-9622(91)70113-G"},{"key":"42011","doi-asserted-by":"crossref","unstructured":"2. Dr\u00e9no B, Cerio R, Dirschka T, et al. A Novel Actinic Keratosis Field Assessment Scale for Grading Actinic Keratosis Disease Severity. Acta Derm Venereol 2017;97:1108-13.","DOI":"10.2340\/00015555-2710"},{"key":"42012","doi-asserted-by":"crossref","unstructured":"3. Dirschka T, Pellacani G, Micali G, et al; Athens AK Study Group. A proposed scoring system for assessing the severity of actinic keratosis on the head: actinic keratosis area and severity index. J Eur Acad Dermatol Venereol 2017;31:1295-302.","DOI":"10.1111\/jdv.14267"},{"key":"42013","doi-asserted-by":"crossref","unstructured":"4. Hayes S. Dermoscopy: the dermatologist's stethoscope. Clin Exp Dermatol 2024;49:955.","DOI":"10.1093\/ced\/llae241"},{"key":"42014","doi-asserted-by":"crossref","unstructured":"5. Abramovits W, Stevenson LC. Changing paradigms in dermatology: new ways to examine the skin using noninvasive imaging methods. Clin Dermatol 2003;21:353-8.","DOI":"10.1016\/j.clindermatol.2003.08.010"},{"key":"42015","doi-asserted-by":"crossref","unstructured":"6. de Oliveira ECV, da Motta VRV, Pantoja PC, et al. Actinic keratosis - review for clinical practice. Int J Dermatol 2019;58:400-7.","DOI":"10.1111\/ijd.14147"},{"key":"42016","doi-asserted-by":"crossref","unstructured":"7. Schmitz L, Kahl P, Majores M, et al. Actinic keratosis: correlation between clinical and histological classification systems. J Eur Acad Dermatol Venereol 2016;30:1303-7.","DOI":"10.1111\/jdv.13626"},{"key":"42017","doi-asserted-by":"crossref","unstructured":"8. Fernandez Figueras MT. From actinic keratosis to squamous cell carcinoma: pathophysiology revisited. J Eur Acad Dermatol Venereol 2017;31:5-7.","DOI":"10.1111\/jdv.14151"},{"key":"42018","doi-asserted-by":"crossref","unstructured":"9. Schlesinger T, Kircik L, Lebwohl M, et al. Patient-and Clinician-Reported Outcomes for Tirbanibulin in Actinic Keratosis in Clinical Practice Across the United States (PROAK). J Drugs Dermatol 2024;23:338-46.","DOI":"10.36849\/JDD.8264"},{"key":"42019","doi-asserted-by":"crossref","unstructured":"10. Thamm JR, Welzel J, Schuh S. Diagnosis and therapy of actinic keratosis. J Dtsch Dermatol Ges 2024;22:675-90.","DOI":"10.1111\/ddg.15288"},{"key":"42020","doi-asserted-by":"crossref","unstructured":"11. Worley B, Harikumar V, Reynolds K, et al. Treatment of actinic keratosis: a systematic review. Arch Dermatol Res 2023;315:1099-108.","DOI":"10.1007\/s00403-022-02490-5"},{"key":"42021","doi-asserted-by":"crossref","unstructured":"12. de Vries K, Prens EP. Laser treatment and its implications for photodamaged skin and actinic keratosis. Curr Probl Dermatol 2015;46:129-35.","DOI":"10.1159\/000367958"},{"key":"42022","doi-asserted-by":"crossref","unstructured":"13. Tai F, Shah M, Pon K, Alavi A. Laser Resurfacing Monotherapy for the Treatment of Actinic Keratosis. J Cutan Med Surg 2021;25:634-42.","DOI":"10.1177\/12034754211027515"},{"key":"42023","doi-asserted-by":"crossref","unstructured":"14. Micali G, Verz\u00ec AE, Barresi S, et al. Field cancerization in clinically solitary actinic keratosis: A pilot study. Dermatol Ther 2021;34:e14607.","DOI":"10.1111\/dth.14607"},{"key":"42024","doi-asserted-by":"crossref","unstructured":"15. Yang X, Chan H, Long W, et al. Dermoscopic Monitoring for Treatment and Follow\u2011Up of Actinic Keratosis With 5\u2011Aminolaevulinic Acid Photodynamic Therapy. Technol Cancer Res Treat 2018;17:1533033818820091.","DOI":"10.1177\/1533033818820091"},{"key":"42025","unstructured":"16. Miller MB, Padilla A. CO2 Laser Ablative Fractional Resurfacing Photodynamic Therapy for Actinic Keratosis and Nonmelanoma Skin Cancer: A Randomized Split\u2011Side Study. Cutis 2020;105:251-4."},{"key":"42026","unstructured":"17. Lallas A, Kyrgidis A, Tzellos T, et al. The role of teledermatology and teledermoscopy in the diagnosis of actinic keratosis and field cancerization: a prospective study. J Invest Dermatol 2021;141:1372-9."}],"container-title":["Dermatology Reports"],"original-title":[],"link":[{"URL":"https:\/\/journals.pagepress.net\/dr\/article\/download\/10638\/9984","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.pagepress.net\/dr\/article\/download\/10638\/9984","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T13:30:46Z","timestamp":1784640646000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.pagepress.net\/dr\/article\/view\/10638"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,21]]},"references-count":17,"URL":"https:\/\/doi.org\/10.4081\/dr.2026.10638","relation":{},"ISSN":["2036-7406","2036-7392"],"issn-type":[{"value":"2036-7406","type":"electronic"},{"value":"2036-7392","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7,21]]}}}