{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T15:12:49Z","timestamp":1778857969205,"version":"3.51.4"},"reference-count":9,"publisher":"PAGEPress Publications","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatol Reports"],"abstract":"<jats:p>Dear Editor,\nMerkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine skin cancer predominantly affecting elderly males, with a median age at diagnosis of 76 years. Its pathogenesis is linked to three main risk factors: UV exposure, Merkel cell polyomavirus (MCPyV) infection, and immunosuppression. Standard management of localized disease (stage I\/II) consists of wide local excision with sentinel lymph node biopsy (SLNB), followed by adjuvant radiotherapy according to disease stage. Despite optimal multimodal treatment, prognosis remains poor, with more than 50% of patients progressing to metastatic disease and a median overall survival of approximately 20 months with first-line avelumab. [...]<\/jats:p>","DOI":"10.4081\/dr.2026.10799","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T14:21:25Z","timestamp":1778854885000},"source":"Crossref","is-referenced-by-count":0,"title":["Spontaneous remission of Merkel cell carcinoma presenting with tertiary lymphoid structures in an immunocompetent patient"],"prefix":"10.4081","author":[{"given":"Luigi","family":"Cerbone","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessia","family":"Garau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiziana","family":"Borra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Barbieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Parisi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Leporati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Ghiglione","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Grosso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2549","published-online":{"date-parts":[[2026,5,15]]},"reference":[{"key":"40181","doi-asserted-by":"crossref","unstructured":"1. Schadendorf D, Lebb\u00e9 C, Zur Hausen A, et al. Merkel cell carcinoma: epidemiology, prognosis, therapy and unmet medical needs. Eur J Cancer 2017;71:53-69.","DOI":"10.1016\/j.ejca.2016.10.022"},{"key":"40182","doi-asserted-by":"crossref","unstructured":"2. Lugowska I, Becker JC, Ascierto PA, et al; ESMO Guidelines Committee. Merkel-cell carcinoma: ESMO-EURACAN Clinical Practice Guideline for diagnosis, treatment, and follow-up. ESMO Open 2024;9:102977.","DOI":"10.1016\/j.esmoop.2024.102977"},{"key":"40183","doi-asserted-by":"crossref","unstructured":"3. Levy S, Aarts MJB, Eskens FALM, et al. Avelumab for advanced Merkel cell carcinoma in the Netherlands: a real-world cohort. J Immunother Cancer 2020;8:e001076.","DOI":"10.1136\/jitc-2020-001076"},{"key":"40184","doi-asserted-by":"crossref","unstructured":"4. D\u2019Angelo SP, Lebb\u00e9 C, Mortier L, et al. First-line avelumab in a cohort of 116 patients with metastatic Merkel cell carcinoma (JAVELIN Merkel 200): primary and biomarker analyses of a phase II study. J Immunother Cancer 2021;9:e002646.","DOI":"10.1136\/jitc-2021-002646"},{"key":"40185","doi-asserted-by":"crossref","unstructured":"5. Okamoto O, Yoshiyama M, Takayasu S, Yokoyama S. Merkel cell carcinoma: report of three cases. J Dermatol 1998;25:45-50.","DOI":"10.1111\/j.1346-8138.1998.tb02345.x"},{"key":"40186","doi-asserted-by":"crossref","unstructured":"6. Gamissans M, Muntaner-Virgili C, Pen\u00edn RM, Marcoval J. Characteristics of spontaneous regression of Merkel cell carcinoma: a retrospective analysis of patient and tumour features. Clin Exp Dermatol 2025;50:994-7.","DOI":"10.1093\/ced\/llae508"},{"key":"40187","unstructured":"7. Branch S, Maloney K, Purcell SM. Spontaneous regression of Merkel cell carcinoma. Cutis 2018;101:301-5."},{"key":"40188","doi-asserted-by":"crossref","unstructured":"8. Nakamura M, Yoshimitsu M, Magara T, et al. Analyses of tertiary lymphoid structures observed in cases of Merkel cell carcinoma showing spontaneous regression. Exp Dermatol 2024;33:e15062.","DOI":"10.1111\/exd.15062"},{"key":"40189","doi-asserted-by":"crossref","unstructured":"9. Srinivas N, Spassova I, Lei KC, et al. Tertiary lymphoid structures in Merkel cell carcinoma facilitate na\u00efve and central memory T-cell infiltration linked to immunotherapy response. J Immunother Cancer 2025;13:e012224.","DOI":"10.1136\/jitc-2025-012224"}],"container-title":["Dermatology Reports"],"original-title":[],"link":[{"URL":"https:\/\/journals.pagepress.net\/dr\/article\/download\/10799\/9936","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.pagepress.net\/dr\/article\/download\/10799\/9936","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T14:21:33Z","timestamp":1778854893000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.pagepress.net\/dr\/article\/view\/10799"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,15]]},"references-count":9,"URL":"https:\/\/doi.org\/10.4081\/dr.2026.10799","relation":{},"ISSN":["2036-7406","2036-7392"],"issn-type":[{"value":"2036-7406","type":"electronic"},{"value":"2036-7392","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5,15]]}}}