{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T11:21:29Z","timestamp":1783336889392,"version":"3.54.6"},"reference-count":13,"publisher":"PAGEPress Publications","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatol Reports"],"abstract":"<jats:p>Folliculitis is a common inflammatory skin condition for which non-antibiotic topical management options remain limited. This pilot study reports clinical performance, safety, and feasibility data from the use of a medical device gel containing hyaluronic acid (HA) and hydrogen peroxide used in dermatologic practice. Adults aged 18-45 years with a diagnosis of folliculitis applied the gel for 8 weeks according to the instructions for use. Clinical outcomes included lesion count, Total Severity Score (TSS), Investigator Global Assessment of Performance (IGAP), patient satisfaction, and Dermatology Life Quality Index (DLQI). Safety was assessed through adverse event (AE) reporting. Thirteen patients (mean age 30.1\u00b17.7 years) were included. Enrollment rate and study conduct supported the feasibility of a future comparative trial. From baseline to week 8, mean lesion count showed a three-fold reduction, accompanied by a 66.6% improvement in TSS. Investigator- and patient-reported assessments indicated consistent clinical improvement with a positive impact on quality of life. Two mild and transient local effects were reported. Overall, these preliminary observations suggest favorable safety and performance of the gel in routine folliculitis management and support further controlled studies.<\/jats:p>","DOI":"10.4081\/dr.2026.10810","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T10:59:12Z","timestamp":1783335552000},"source":"Crossref","is-referenced-by-count":0,"title":["Pilot study of topical management of folliculitis: clinical outcomes and safety in routine practice"],"prefix":"10.4081","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6581-1338","authenticated-orcid":false,"given":"Meda-Elena","family":"Stefancu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dionisio Franco","family":"Barattini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9687-606X","authenticated-orcid":false,"given":"Ionel","family":"Botnaru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8601-7785","authenticated-orcid":false,"given":"Carmen","family":"Vizman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9725-3518","authenticated-orcid":false,"given":"Luca","family":"Stucchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5568-5916","authenticated-orcid":false,"given":"Luca","family":"Barattini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2549","published-online":{"date-parts":[[2026,7,6]]},"reference":[{"key":"41776","doi-asserted-by":"crossref","unstructured":"1. Stevens DL, Bisno AL, Chambers HF, et al. Practice guidelines for the diagnosis and management of skin and soft tissue infections: 2014 update by the Infectious Diseases Society of America. Clin Infect Dis 2014;59:e10-52.","DOI":"10.1093\/cid\/ciu296"},{"key":"41777","unstructured":"2. Zha M, Usatine R. Common skin conditions in children and adolescents: bacterial infections. FP Essent 2024;541:14-9."},{"key":"41778","unstructured":"3. Veraldi S, Micali G, Berardesca E, et al. Results of a multicenter, randomized, controlled trial of a hydrogen peroxide\u2013based kit versus a benzoyl peroxide\u2013based kit in mild-to-moderate acne. J Clin Aesthet Dermatol 2016;9:50-4."},{"key":"41779","doi-asserted-by":"crossref","unstructured":"4. Stefancu ME, Barattini DF, Botnaru I, et al. Performance and safety of the medical device Ialuxid Gel in the treatment of mild-to-moderate acne vulgaris: an open-label, noncomparative multicenter clinical trial. J Cosmet Dermatol 2025;24:e70084.","DOI":"10.1111\/jocd.70084"},{"key":"41780","doi-asserted-by":"crossref","unstructured":"5. Lin HS, Lin PT, Tsai YS, et al. Interventions for bacterial folliculitis and boils (furuncles and carbuncles). Cochrane Database Syst Rev 2021;2:CD013099.","DOI":"10.1002\/14651858.CD013099.pub2"},{"key":"41781","doi-asserted-by":"crossref","unstructured":"6. Eldridge SM, Chan CL, Campbell MJ, et al; PAFS consensus group. CONSORT 2010 statement: extension to randomised pilot and feasibility trials. BMJ 2016;355:i5239.","DOI":"10.1136\/bmj.i5239"},{"key":"41782","doi-asserted-by":"crossref","unstructured":"7. Pereira H, Sousa DA, Cunha A, et al. Hyaluronic acid. Adv Exp Med Biol 2018;1059:137-53.","DOI":"10.1007\/978-3-319-76735-2_6"},{"key":"41783","doi-asserted-by":"crossref","unstructured":"8. Salwowska NM, Bebenek KA, \u017b\u0105d\u0142o DA, Wcis\u0142o-Dziadecka DL. Physiochemical properties and application of hyaluronic acid: a systematic review. J Cosmet Dermatol 2016;15:520-6.","DOI":"10.1111\/jocd.12237"},{"key":"41784","unstructured":"9. Keen MA. Hyaluronic acid in dermatology. Skinmed 2017;15:441-8."},{"key":"41785","doi-asserted-by":"crossref","unstructured":"10. Kapoor P, Kumar S. Hydrogen peroxide in dermatology. Indian J Dermatol Venereol Leprol 2023;89:310-2.","DOI":"10.25259\/IJDVL_292_2021"},{"key":"41786","doi-asserted-by":"crossref","unstructured":"11. Milani M, Bigardi A, Zavattarelli M. Efficacy and safety of stabilized hydrogen peroxide cream (Crystacide) in mild-to-moderate acne vulgaris: a randomized, controlled trial versus benzoyl peroxide gel. Curr Med Res Opin 2003;19:135-8.","DOI":"10.1080\/030079903125001523"},{"key":"41787","doi-asserted-by":"crossref","unstructured":"12. Inoue K, Takei K, Denda M. Functional glycine receptor in cultured human keratinocytes. Exp Dermatol 2015;24:307-9.","DOI":"10.1111\/exd.12651"},{"key":"41788","doi-asserted-by":"crossref","unstructured":"13. Billingham SA, Whitehead AL, Julious SA. An audit of sample sizes for pilot and feasibility trials registered in the UK Clinical Research Network. BMC Med Res Methodol 2013;13:104.","DOI":"10.1186\/1471-2288-13-104"}],"container-title":["Dermatology Reports"],"original-title":[],"link":[{"URL":"https:\/\/journals.pagepress.net\/dr\/article\/download\/10810\/9969","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.pagepress.net\/dr\/article\/download\/10810\/9968","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.pagepress.net\/dr\/article\/download\/10810\/9969","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T10:59:35Z","timestamp":1783335575000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.pagepress.net\/dr\/article\/view\/10810"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,6]]},"references-count":13,"URL":"https:\/\/doi.org\/10.4081\/dr.2026.10810","relation":{},"ISSN":["2036-7406","2036-7392"],"issn-type":[{"value":"2036-7406","type":"electronic"},{"value":"2036-7392","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7,6]]}}}