{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:50:19Z","timestamp":1787755819363,"version":"build-2784847793"},"reference-count":17,"publisher":"PAGEPress Publications","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatol Reports"],"abstract":"<jats:p>Psoriatic patients have increased cardiometabolic risk and elevated serum leptin levels; however, the association between these factors remains unknown. In this report, serum leptin and the atherogenic index of plasma (AIP) were measured in a cross-sectional study of 100 patients with psoriasis. The results showed that the mean \u00b1 standard deviation (SD) serum leptin was 19.9\u00b19.7 ng\/mL. AIP was 0.3\u00b10.06; 46% of patients were classified as low risk, 15% as intermediate risk, and 39% as high risk. Leptin levels increased with age, body mass index (BMI), and AIP and were associated with a twofold increase in the likelihood of elevated AIP (odds ratio [OR]=2.0; p=0.025). AIP was an independent predictor for higher leptin levels. These data suggest that serum leptin and AIP are linked in psoriasis and may reflect a shared inflammatory mechanism that contributes to increased cardiovascular risk.\n\u00a0<\/jats:p>","DOI":"10.4081\/dr.2026.10817","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:49:44Z","timestamp":1787752184000},"source":"Crossref","is-referenced-by-count":0,"title":["The association between serum leptin level and the atherogenic index of plasma in psoriatic patients"],"prefix":"10.4081","author":[{"given":"Samer A.","family":"Dhaher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Budoor O.","family":"Yousif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazar S.","family":"Haddad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2549","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"42825","doi-asserted-by":"crossref","unstructured":"1. Garshick MS, Ward NL, Krueger JG, Berger JS. Cardiovascular risk in patients with psoriasis: JACC review Topic of the week. J Am Coll Cardiol 2021;77:1670-80.","DOI":"10.1016\/j.jacc.2021.02.009"},{"key":"42826","doi-asserted-by":"crossref","unstructured":"2. Piaserico S, Orlando G, Messina F. Psoriasis and cardiometabolic diseases: shared genetic and molecular pathways. Int J Mol Sci 2022;23:9063.","DOI":"10.3390\/ijms23169063"},{"key":"42827","doi-asserted-by":"crossref","unstructured":"3. S\u0142uczanowska-G\u0142abowska S, Staniszewska M, Marchlewicz M, et al. Adiponectin, leptin and resistin in patients with psoriasis. J Clin Med 2023;12:663.","DOI":"10.3390\/jcm12020663"},{"key":"42828","doi-asserted-by":"crossref","unstructured":"4. Xue K, Liu H, Jian Q, et al. Leptin induces secretion of pro-inflammatory cytokines by human keratinocytes in vitro--a possible reason for increased severity of psoriasis in patients with a high body mass index. Exp Dermatol 2013;22:406-10.","DOI":"10.1111\/exd.12162"},{"key":"42829","doi-asserted-by":"crossref","unstructured":"5. Vadacca M, Margiotta DP, Navarini L, Afeltra A. Leptin in immuno-rheumatological diseases. Cell Mol Immunol 2011;8:203-12.","DOI":"10.1038\/cmi.2010.75"},{"key":"42830","doi-asserted-by":"crossref","unstructured":"6. Radi\u0107 M, Belan\u010di\u0107 A, \u0110oga\u0161 H, et al. Cardiometabolic risk in psoriatic arthritis: a hidden burden of inflammation and metabolic dysregulation. Metabolites 2025;15:206.","DOI":"10.3390\/metabo15030206"},{"key":"42831","unstructured":"7. Niroumand S, Khajedaluee M, Khadem-Rezaiyan M, et al. Atherogenic index of plasma (AIP): a marker of cardiovascular disease. Med J Islam Repub Iran 2015;29:240."},{"key":"42832","doi-asserted-by":"crossref","unstructured":"8. Dobi\u00e1sov\u00e1 M, Frohlich J. The plasma parameter log (TG\/HDL-C) as an atherogenic index: correlation with lipoprotein particle size and esterification rate in apoB-lipoprotein-depleted plasma (FER(HDL)). Clin Biochem 2001;34:583-8.","DOI":"10.1016\/S0009-9120(01)00263-6"},{"key":"42833","doi-asserted-by":"crossref","unstructured":"9. Mustafa BI. Gender differences of serum leptin hormone levels in Iraqi population. Iraqi J Pharm Sci 2006;15:53-6.","DOI":"10.31351\/vol15iss1pp53-57"},{"key":"42834","doi-asserted-by":"crossref","unstructured":"10. Ibrahim AJ, Dwesh HAW, Shahid RA. Evaluation of serum leptin levels in hypertensive men in Thi Qar City-Iraq (a comparative study). J Popul Ther Clin Pharmacol 2023;30:e54-62.","DOI":"10.47750\/jptcp.2023.30.03.007"},{"key":"42835","doi-asserted-by":"crossref","unstructured":"11. Bakr DQ, Abed AY. The Association between leptin and asprosin levels in female patients with type II diabetes mellitus. J Fac Med Baghdad 2024;66:368-73.","DOI":"10.32007\/jfacmedbaghdad.6632346"},{"key":"42836","doi-asserted-by":"crossref","unstructured":"12. Hwang J, Yoo JA, Yoon H, et al. The Role of leptin in the association between obesity and psoriasis. Biomol Ther (Seoul) 2021;29:11-21.","DOI":"10.4062\/biomolther.2020.054"},{"key":"42837","doi-asserted-by":"crossref","unstructured":"13. Hellstr\u00f6m L, Wahrenberg H, Hruska K, et al. Mechanisms behind gender differences in circulating leptin levels. J Intern Med 2000;247:457-62.","DOI":"10.1046\/j.1365-2796.2000.00678.x"},{"key":"42838","doi-asserted-by":"crossref","unstructured":"14. Tuo Y, He J, Guo T. Associations between the atherogenic index of plasma and psoriasis among US adults: A cross-sectional study based on NHANES 2009 to 2014. Medicine (Baltimore) 2024;103:e40955.","DOI":"10.1097\/MD.0000000000040955"},{"key":"42839","unstructured":"15. Gonzalez-Gonzalez V, Colunga I, Galarza-Delgado D, et al. Higher values of atherogenic index of plasma are correlated with increased cardiovascular risk in patients with psoriatic arthritis. Arthritis Rheumatol 2023;75."},{"key":"42840","doi-asserted-by":"crossref","unstructured":"16. Baran A, Flisiak I, Jaroszewicz J, \u015awiderska M. Effect of psoriasis activity on serum adiponectin and leptin levels. Postepy Dermatol Alergol 2015;32:101-6.","DOI":"10.5114\/pdia.2014.40960"},{"key":"42841","doi-asserted-by":"crossref","unstructured":"17. Kaur S, Zilmer K, Leping V, Zilmer M. The levels of adiponectin and leptin and their relation to other markers of cardiovascular risk in patients with psoriasis. J Eur Acad Dermatol Venereol 2011;25:1328-33.","DOI":"10.1111\/j.1468-3083.2011.03982.x"}],"container-title":["Dermatology Reports"],"original-title":[],"link":[{"URL":"https:\/\/journals.pagepress.net\/dr\/article\/download\/10817\/9998","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.pagepress.net\/dr\/article\/download\/10817\/9999","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.pagepress.net\/dr\/article\/download\/10817\/9998","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:49:46Z","timestamp":1787752186000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.pagepress.net\/dr\/article\/view\/10817"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,26]]},"references-count":17,"URL":"https:\/\/doi.org\/10.4081\/dr.2026.10817","relation":{},"ISSN":["2036-7406","2036-7392"],"issn-type":[{"value":"2036-7406","type":"electronic"},{"value":"2036-7392","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8,26]]}}}