{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T14:20:25Z","timestamp":1789395625600,"version":"build-2803163510"},"reference-count":20,"publisher":"PAGEPress Publications","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatol Reports"],"abstract":"<jats:p>Keloids are fibroproliferative skin tumors characterized by excessive collagen deposition and persistent inflammation. Interleukin (IL)-6 plays a key role in wound healing and fibrosis, and promoter polymorphisms of the IL-6 gene have been implicated in keloid susceptibility in several populations. However, data on Vietnamese patients remain limited. We conducted a case-control study including 47 patients with clinically diagnosed keloids and 43 age- and sex-matched healthy controls to investigate the association between the IL-6 rs1800796 (\u2212572 C&gt;G) polymorphism and both keloid susceptibility and scar severity. Genotyping was performed using allele-specific oligonucleotide \u2013 polymerase chain reaction (ASO-PCR). Scar severity was assessed using the Vancouver Scar Scale (VSS). The CG genotype and G allele were significantly more frequent in patients with keloid than in controls. Carriers of the G allele demonstrated an increased risk of keloid formation and exhibited progressively higher VSS scores compared with CC homozygotes. These findings suggest that the IL-6 rs1800796 G allele is associated with increased susceptibility to keloids and greater scar severity in Vietnamese patients.<\/jats:p>","DOI":"10.4081\/dr.2026.10835","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T13:22:33Z","timestamp":1789046553000},"source":"Crossref","is-referenced-by-count":0,"title":["Association of interleukin-6 rs1800796 polymorphism with keloid susceptibility and severity in a Vietnamese population: a case-control study"],"prefix":"10.4081","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5384-2603","authenticated-orcid":false,"given":"Nam Hao","family":"Chau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoai Thu","family":"Le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phuong Anh","family":"Huynh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nhu Nhat Quynh","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9453-7172","authenticated-orcid":false,"given":"Trung The","family":"Van","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2549","published-online":{"date-parts":[[2026,9,10]]},"reference":[{"key":"43275","doi-asserted-by":"crossref","unstructured":"1. Chike-Obi CJ, Cole PD, Brissett AE. Keloids: pathogenesis, clinical features, and management. Semin Plast Surg 2009;23:178-84.","DOI":"10.1055\/s-0029-1224797"},{"key":"43276","doi-asserted-by":"crossref","unstructured":"2. Knowles A, Glass DA, 2nd. Keloids and Hypertrophic Scars. Dermatol Clin 2023;41:509-17.","DOI":"10.1016\/j.det.2023.02.010"},{"key":"43277","unstructured":"3. McGinty S, Siddiqui WJ. Keloid. Treasure Island (FL): StatPearls [Internet]; 2025 [updated 2023 Jul 17]. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK507899\/."},{"key":"43278","doi-asserted-by":"crossref","unstructured":"4. Latoni DI, McDaniel DC, Tsao H, Tsao SS. Update on the Pathogenesis of Keloid Formation. JID Innov 2024;4:100299.","DOI":"10.1016\/j.xjidi.2024.100299"},{"key":"43279","doi-asserted-by":"crossref","unstructured":"5. Wang ZC, Zhao WY, Cao Y, et al. The Roles of Inflammation in Keloid and Hypertrophic Scars. Front Immunol 2020;11:603187.","DOI":"10.3389\/fimmu.2020.603187"},{"key":"43280","doi-asserted-by":"crossref","unstructured":"6. Nangole FW, Agak GW. Keloid pathophysiology: fibroblast or inflammatory disorders? JPRAS Open 2019;22:44-54.","DOI":"10.1016\/j.jpra.2019.09.004"},{"key":"43281","doi-asserted-by":"crossref","unstructured":"7. Mahmoud NN, Hamad K, Al Shibitini A, et al. Investigating Inflammatory Markers in Wound Healing: Understanding Implications and Identifying Artifacts. ACS Pharmacol Transl Sci 2024;7:18-27.","DOI":"10.1021\/acsptsci.3c00336"},{"key":"43282","doi-asserted-by":"crossref","unstructured":"8. Johnson BZ, Stevenson AW, Prele CM, et al. The Role of IL-6 in Skin Fibrosis and Cutaneous Wound Healing. Biomedicines 2020;8.","DOI":"10.3390\/biomedicines8050101"},{"key":"43283","doi-asserted-by":"crossref","unstructured":"9. Ghazizadeh M. Essential role of IL-6 signaling pathway in keloid pathogenesis. J Nippon Med Sch 2007;74:11-22.","DOI":"10.1272\/jnms.74.11"},{"key":"43284","doi-asserted-by":"crossref","unstructured":"10. Ghazizadeh M, Tosa M, Shimizu H, et al. Functional implications of the IL-6 signaling pathway in keloid pathogenesis. J Invest Dermatol 2007;127:98-105.","DOI":"10.1038\/sj.jid.5700564"},{"key":"43285","doi-asserted-by":"crossref","unstructured":"11. Liu M. Cytokines, chemokines and growth factors involved in keloids pathogenesis. An Bras Dermatol 2025;100:300-7.","DOI":"10.1016\/j.abd.2024.01.010"},{"key":"43286","doi-asserted-by":"crossref","unstructured":"12. Liu S, Yang H, Song J, et al. Keloid: Genetic susceptibility and contributions of genetics and epigenetics to its pathogenesis. Exp Dermatol 2022;31:1665-75.","DOI":"10.1111\/exd.14671"},{"key":"43287","doi-asserted-by":"crossref","unstructured":"13. Tosa M, Watanabe A, Ghazizadeh M. IL-6 Polymorphism and Susceptibility to Keloid Formation in a Japanese Population. J Invest Dermatol 2016;136:1069-72.","DOI":"10.1016\/j.jid.2016.01.019"},{"key":"43288","doi-asserted-by":"crossref","unstructured":"14. Zhu XJ, Li WZ, Li H, et al. Association of interleukin-6 gene polymorphisms and circulating levels with keloid scars in a Chinese Han population. Genet Mol Res 2017;16:gmr16029110.","DOI":"10.4238\/gmr16029110"},{"key":"43289","doi-asserted-by":"crossref","unstructured":"15. Allah AMKA, Mohammed KI, Farag AGA, et al. Interleukin-6 serum level and gene polymorphism in keloid patients. Cell Mol Biol 2019;65:43-8.","DOI":"10.14715\/cmb\/2019.65.5.7"},{"key":"43290","doi-asserted-by":"crossref","unstructured":"16. Ogawa R. Japan Scar Workshop (JSW) Scar Scale (JSS) for Assessing Keloids and Hypertrophic Scars. In: Teot L, Mustoe TA, Middelkoop E, Gauglitz GG, editors. Textbook on Scar Management: State of the Art Management and Emerging Technologies [Internet]. Springer; 2020. p. 133-40.","DOI":"10.1007\/978-3-030-44766-3_15"},{"key":"43291","doi-asserted-by":"crossref","unstructured":"17. Sullivan T, Smith J, Kermode J, et al. Rating the burn scar. J Burn Care Rehabil 1990;11:256-60.","DOI":"10.1097\/00004630-199005000-00014"},{"key":"43292","doi-asserted-by":"crossref","unstructured":"18. Dmytrzak A, Lewandowska K, Boron A, et al. No Association of Polymorphisms in the Genes Encoding Interleukin-6 and Interleukin-6 Receptor Subunit Alpha with the Risk of Keloids in Polish Patients. Int J Mol Sci 2024;25:5284.","DOI":"10.3390\/ijms25105284"},{"key":"43293","doi-asserted-by":"crossref","unstructured":"19. Lee CC, Tsai CH, Chen CH, et al. An updated review of the immunological mechanisms of keloid scars. Front Immunol 2023;14:1117630.","DOI":"10.3389\/fimmu.2023.1117630"},{"key":"43294","doi-asserted-by":"crossref","unstructured":"20. Uitto J. IL-6 signaling pathway in keloids: a target for pharmacologic intervention? J Invest Dermatol 2007;127:6-8.","DOI":"10.1038\/sj.jid.5700604"}],"container-title":["Dermatology Reports"],"original-title":[],"link":[{"URL":"https:\/\/journals.pagepress.net\/dr\/article\/download\/10835\/10010","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.pagepress.net\/dr\/article\/download\/10835\/10010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T13:47:59Z","timestamp":1789393679000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.pagepress.net\/dr\/article\/view\/10835"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,10]]},"references-count":20,"URL":"https:\/\/doi.org\/10.4081\/dr.2026.10835","relation":{},"ISSN":["2036-7406","2036-7392"],"issn-type":[{"value":"2036-7406","type":"electronic"},{"value":"2036-7392","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9,10]]}}}