{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T13:03:59Z","timestamp":1784725439200,"version":"3.55.0"},"reference-count":4,"publisher":"PAGEPress Publications","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatol Reports"],"abstract":"<jats:p>Dear Editor,\nKimura disease (KD) is a rare, chronic inflammatory condition characterized by subcutaneous nodules, lymphadenopathy, peripheral and tissue eosinophilia, and markedly elevated serum IgE concentrations. Although its precise etiopathogenesis remains incompletely defined, accumulating evidence supports its classification as a type 2 immune-mediated disorder, sustained by Th2 lymphocyte activation and overexpression of interleukin (IL)-4 and IL-13 signaling pathways. This immunological milieu promotes eosinophilic infiltration, vascular proliferation, IgE overproduction, and persistent pruritus, ultimately driving both systemic and cutaneous manifestations of the disease. [...]<\/jats:p>","DOI":"10.4081\/dr.2026.10839","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T12:08:37Z","timestamp":1784722117000},"source":"Crossref","is-referenced-by-count":0,"title":["Dupilumab as a targeted therapeutic strategy for Th2-driven cutaneous manifestations in Kimura disease"],"prefix":"10.4081","author":[{"given":"Gaetano","family":"Licata","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Balato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Argenziano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina Mariarosaria","family":"Giorgio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2549","published-online":{"date-parts":[[2026,7,22]]},"reference":[{"key":"42027","doi-asserted-by":"crossref","unstructured":"1. Cordeil S, Hermine O, Hot A. Diagnostic challenges and updated therapeutic strategies of Kimura's disease: A case report successfully treated by dupilumab and review. Medicine (Baltimore) 2023;102:e34191.","DOI":"10.1097\/MD.0000000000034191"},{"key":"42028","doi-asserted-by":"crossref","unstructured":"2. Battesti G, Jachiet M, Lepelletier C, et al. Two cases of dupilumab-responsive Kimura disease. Clin Exp Dermatol 2024;49:502-6.","DOI":"10.1093\/ced\/llad455"},{"key":"42029","doi-asserted-by":"crossref","unstructured":"3. Luo SY, Zhou KY, Wang QX, et al. Kimura\u2019s disease treated with dupilumab: A case report and literature review. Int Immunopharmacol 2024;131:111895.","DOI":"10.1016\/j.intimp.2024.111895"},{"key":"42030","doi-asserted-by":"crossref","unstructured":"4. Yang B, Yu H, Jia M, et al. Dupilumab Rapidly Reduces IgE and Eosinophil Values in Kimura Disease: Sustained Remission Achieved. J Investig Allergol Clin Immunol 2025:0.","DOI":"10.18176\/jiaci.1126"}],"container-title":["Dermatology Reports"],"original-title":[],"link":[{"URL":"https:\/\/journals.pagepress.net\/dr\/article\/download\/10839\/9985","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.pagepress.net\/dr\/article\/download\/10839\/9985","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T12:08:39Z","timestamp":1784722119000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.pagepress.net\/dr\/article\/view\/10839"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,22]]},"references-count":4,"URL":"https:\/\/doi.org\/10.4081\/dr.2026.10839","relation":{},"ISSN":["2036-7406","2036-7392"],"issn-type":[{"value":"2036-7406","type":"electronic"},{"value":"2036-7392","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7,22]]}}}