{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:51:25Z","timestamp":1791445885485,"version":"4.3.3"},"reference-count":23,"publisher":"PAGEPress Publications","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatol Reports"],"abstract":"<jats:p>Diabetes mellitus (DM) is frequently associated with cutaneous complications, including xerosis cutis, due to impaired skin barrier function. Red palm oil (RPO; Elaeis guineensis Jacq.) contains bioactive compounds with antioxidant, anti-inflammatory, and barrier-repair properties that may improve skin hydration.\u00a0The objective of this study was to evaluate the effect of topical RPO on skin hydration in streptozotocin (STZ)-induced diabetic rat models. Thirty-two male Sprague-Dawley rats were randomly assigned to four groups (n=8 each): normal control (G1), untreated diabetic (G2), diabetic treated with 10% urea cream (G3), and diabetic treated with RPO (G4). Diabetes was induced using STZ and confirmed by blood glucose measurement. Treatments were applied once daily for 28 days to a standardized dorsal skin area. Skin hydration was assessed using a Corneometer\u00ae. Data were analyzed using the Shapiro-Wilk test and one-way analysis of variance (ANOVA) followed by the Tukey post hoc test. Skin hydration differed significantly among groups (p&lt;0.001). The highest mean hydration was observed in the normal group (34.13 arbitrary units [AU]), while the lowest was in untreated diabetic rats (14.38 AU). RPO treatment significantly increased skin hydration (29.00 AU) compared to untreated diabetic rats (p&lt;0.001) and urea-treated rats (p&lt;0.001). No significant difference was found between the RPO-treated and normal groups (p=0.082).\u00a0To conclude, topical RPO significantly improves skin hydration in diabetic rats, with effects comparable to normal skin and superior to 10% urea cream. RPO shows potential as a therapeutic agent for diabetes-associated xerosis.<\/jats:p>","DOI":"10.4081\/dr.2026.10917","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T06:58:07Z","timestamp":1791442687000},"source":"Crossref","is-referenced-by-count":0,"title":["The effect of red palm oil (&lt;i&gt;Elaeis guineensis&lt;\/i&gt; Jacq.) on skin hydration in streptozotocin-induced diabetic white rat models"],"prefix":"10.4081","author":[{"given":"Ariyati","family":"Yosi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4741-1486","authenticated-orcid":false,"given":"Putri Chairani","family":"Eyanoer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6141-4579","authenticated-orcid":false,"given":"Ramona Dumasari","family":"Lubis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2268-6838","authenticated-orcid":false,"given":"Muhammad","family":"Rusda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9894-678X","authenticated-orcid":false,"given":"Irma Damayanti Roesyanto","family":"Mahadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2549","published-online":{"date-parts":[[2026,10,8]]},"reference":[{"key":"44367","doi-asserted-by":"crossref","unstructured":"1. 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Biological and nutritional properties of palm oil and palmitic acid: effects on health. Molecules 2015;20:17339-61.","DOI":"10.3390\/molecules200917339"},{"key":"44375","doi-asserted-by":"crossref","unstructured":"9. Mba OI, Dumont MJ, Ngadi M. Palm oil: processing, characterization and utilization in the food industry \u2013 a review. Food Biosci 2015;10:26-41.","DOI":"10.1016\/j.fbio.2015.01.003"},{"key":"44376","doi-asserted-by":"crossref","unstructured":"10. Khalil A, Tazeddinova D, Aljoumaa K, et al. Carotenoids: therapeutic strategy in the battle against viral emerging diseases. Prev Nutr Food Sci 2021;26:241-61.","DOI":"10.3746\/pnf.2021.26.3.241"},{"key":"44377","doi-asserted-by":"crossref","unstructured":"11. Horikawa T, Hiramoto K, Goto K, et al. Differences in mechanisms of type 1 and type 2 diabetes-induced skin dryness. Int J Med Sci 2020;18:474-81.","DOI":"10.7150\/ijms.50764"},{"key":"44378","doi-asserted-by":"crossref","unstructured":"12. Plyduang T, Atipairin A, Yoon AS, et al. Red palm extract-loaded lipid nanoparticles for anti-aging. Cosmetics 2021;9:3.","DOI":"10.3390\/cosmetics9010003"},{"key":"44379","doi-asserted-by":"crossref","unstructured":"13. Purnama KO, Setyaningsih D, Hambali E, Taniwiryono D. Processing, characteristics, and applications of red palm oil. Int J Oil Palm 2020;3:40-55.","DOI":"10.35876\/ijop.v3i2.47"},{"key":"44380","unstructured":"14. NOF N, Amarachukwu NEL, Ogheneochuko NTP. Wound healing effect of Elaeis guineensis oil. World J Biol Pharm Health Sci 2021;8:13-28."},{"key":"44381","doi-asserted-by":"crossref","unstructured":"15. Nagendran B, Unnithan UR, Choo YM, Sundram K. Characteristics of red palm oil. Food Nutr Bull 2000;21:189-94.","DOI":"10.1177\/156482650002100213"},{"key":"44382","doi-asserted-by":"crossref","unstructured":"16. Kim JH, Kwack MH, Lee WJ. Effects of antioxidants on skin hydration and inflammation. 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