{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T15:19:58Z","timestamp":1787671198494,"version":"build-2736575974"},"reference-count":16,"publisher":"PAGEPress Publications","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatol Reports"],"abstract":"<jats:p>Traditionally recognised as the body\u2019s largest organ, the skin acts as a protective barrier and primary sensory interface with the external environment. Recent advances in dermatology and neuroscience have revealed a sophisticated neuroendocrine network within the skin, suggesting that the skin\u2019s role extends far beyond mere protection and sensation. In this article, we propose an innovative perspective by conceptualising the skin as a \u201cbig eye\u201d in close communication with the central nervous system (CNS). Central to this concept is the idea that all nerve endings in the skin converge into a single extended nerve, like the optic nerve, which we can imagine as a \u201ccutaneous nerve\u201d. This nerve could act as a conduit for the transmission of sensory and emotional information from the skin to the CNS. [...]<\/jats:p>","DOI":"10.4081\/dr.2026.10930","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T14:26:26Z","timestamp":1787667986000},"source":"Crossref","is-referenced-by-count":0,"title":["Neurocutaneous system: Is the skin a big eye with deep brain connections?"],"prefix":"10.4081","author":[{"given":"Fortunato","family":"Cassalia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Danese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Del Fiore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2549","published-online":{"date-parts":[[2026,8,25]]},"reference":[{"key":"42797","doi-asserted-by":"crossref","unstructured":"1. Gravitz L. Skin. Nature 2018;563:S83.","DOI":"10.1038\/d41586-018-07428-4"},{"key":"42798","doi-asserted-by":"crossref","unstructured":"2. Vidal Yucha SE, Tamamoto KA, Nguyen H, et al. Human Skin Equivalents Demonstrate Need for Neuro-Immuno-Cutaneous System. Adv Biosyst 2019;3:e1800283.","DOI":"10.1002\/adbi.201800283"},{"key":"42799","unstructured":"3. Mehra D, Moshirfar M. Neuroanatomy, Optic Tract. 2023. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024."},{"key":"42800","doi-asserted-by":"crossref","unstructured":"4. Pispa J, Thesleff I. Mechanisms of ectodermal organogenesis. Dev Biol 2003;262:195-205.","DOI":"10.1016\/S0012-1606(03)00325-7"},{"key":"42801","doi-asserted-by":"crossref","unstructured":"5. Brombin A, Patton EE. Melanocyte lineage dynamics in development, growth and disease. Development 2024;151:dev201266.","DOI":"10.1242\/dev.201266"},{"key":"42802","doi-asserted-by":"crossref","unstructured":"6. Hara M, Toyoda M, Yaar M, et al. Innervation of melanocytes in human skin. J Exp Med 1996;184:1385-95.","DOI":"10.1084\/jem.184.4.1385"},{"key":"42803","doi-asserted-by":"crossref","unstructured":"7. Ait Oussous S, Jafferany M, Chakiri R. Psychodermatology knowledge, awareness and patterns of practice among Moroccan dermatologists: a national survey study. Clin Exp Dermatol 2023;48:1152-4.","DOI":"10.1093\/ced\/llad204"},{"key":"42804","doi-asserted-by":"crossref","unstructured":"8. Zhang H, Wang M, Zhao X, et al. Role of stress in skin diseases: A neuroendocrine-immune interaction view. Brain Behav Immun 2024;116:286-302.","DOI":"10.1016\/j.bbi.2023.12.005"},{"key":"42805","doi-asserted-by":"crossref","unstructured":"9. Cassalia F, Cazzaniga S, Ofenloch R, et al. Comparison of Perceptions of Skin Condition, Product Use and Allergen Reactivity Between People with Psoriasis and Controls in the European Dermato-Epidemiology Network (EDEN) Fragrance Study. Acta Derm Venereol 2024;104:adv23513.","DOI":"10.2340\/actadv.v104.23513"},{"key":"42806","doi-asserted-by":"crossref","unstructured":"10. Yu H, Miao W, Ji E, et al. Social touch-like tactile stimulation activates a tachykinin 1-oxytocin pathway to promote social interactions. Neuron 2022;110:1051-67.e7.","DOI":"10.1016\/j.neuron.2021.12.022"},{"key":"42807","doi-asserted-by":"crossref","unstructured":"11. Marek-Jozefowicz L, Nedoszytko B, Grochocka M, et al. Molecular Mechanisms of Neurogenic Inflammation of the Skin. Int J Mol Sci 2023;24:5001.","DOI":"10.3390\/ijms24055001"},{"key":"42808","unstructured":"12. Rosenfeld HA. Psychotic States: A Psychoanalytical Approach. London: The Hogarth Press and the Institute of Psycho-Analysis; 1965."},{"key":"42809","unstructured":"13. Sanchez DP, Sonthalia S. Koebner Phenomenon. 2022. In: StatPearls[Internet]. Treasure Island (FL): StatPearls Publishing; 2024."},{"key":"42810","doi-asserted-by":"crossref","unstructured":"14. Hughes TA, McQueen IN, Anstey A, et al. Neurotropic malignant melanoma presenting as a trigeminal sensory neuropathy. J Neurol Neurosurg Psychiatry 1995;58:381-2.","DOI":"10.1136\/jnnp.58.3.381"},{"key":"42811","doi-asserted-by":"crossref","unstructured":"15. Morgado-Carrasco D, Fern\u00e1ndez-Sartorio C, Carrera C. Zosteriform Cutaneous Distant Metastases as Onset of Relapsing Melanoma. Dermatol Pract Concept 2019;10:e2020007.","DOI":"10.5826\/dpc.1001a07"},{"key":"42812","doi-asserted-by":"crossref","unstructured":"16. Goetsch Weisman A, Weiss McQuaid S, Radtke HB, et al. Neurofibromatosis- and schwannomatosis-associated tumors: Approaches to genetic testing and counseling considerations. 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