{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T04:02:24Z","timestamp":1767844944152,"version":"3.49.0"},"reference-count":0,"publisher":"PAGEPress Publications","license":[{"start":{"date-parts":[[2016,11,2]],"date-time":"2016-11-02T00:00:00Z","timestamp":1478044800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2016,11,2]],"date-time":"2016-11-02T00:00:00Z","timestamp":1478044800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":["www.ejh.it"],"crossmark-restriction":true},"short-container-title":["Eur J Histochem"],"abstract":"<jats:p>Nuclear receptors are necessary for uterine invasion of the trophoblast and therefore important for maintaining a viable pregnancy. The aim of this study was to investigate the expression pattern and frequency of LXR, PPAR\u03b3\u00a0and RXR\u03b1 under physiological circumstances and in spontaneous abortions in endometrial glands and decidual tissue cells. A total of 28 (14 physiologic pregnancies\/14 spontaneous abortion) human pregnancies in first trimester were analysed for expression of the nuclear receptors LXR, RXR\u03b1 and PPAR\u03b3. Expression changes were evaluated by immunohistochemistry in decidual tissue and endometrial glands of the decidua. RXR\u03b1 expression was up-regulated in the endometrial glands of spontaneous abortion (P&lt;0.015). Similar up regulation of RXR\u03b1 was found in decidual tissue (P&lt;0.05). LXR and PPAR\u03b3 expression was unchanged in spontaneous abortion. Via Correlation analysis we found a trend to positive correlation of LXR and PPAR\u03b3 (Spearman correlation coefficient r=0.56 P=0.07) in endometrial glands. In decidual tissue, we found significant negative correlation in the control group, for the combination of RXR\u03b1 and PPAR\u03b3 (Spearman correlation coefficient r=0.913, P=0.03).\u00a0 Our data show that RXR\u03b1 expression is increased in miscarriage in endometrial glands and correlation analysis showed that negative correlation between RXR\u03b1 and PPAR\u03b3 disappears in miscarriage. This shift is supposable responsible for the loss of regular function in trophoblast and embryonic tissue.\u00a0\u00a0<\/jats:p>","DOI":"10.4081\/ejh.2016.2665","type":"journal-article","created":{"date-parts":[[2016,11,15]],"date-time":"2016-11-15T05:03:30Z","timestamp":1479186210000},"update-policy":"https:\/\/doi.org\/10.4081\/ejh.crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["RXR\u03b1 is upregulated in first trimester endometrial glands of spontaneous abortions unlike LXR and PPAR\u03b3"],"prefix":"10.4081","author":[{"given":"J.","family":"Knabl","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Vattai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Hu\u0308ttenbrenner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Hutter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Karsten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Jeschke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2549","published-online":{"date-parts":[[2016,11,2]]},"container-title":["European Journal of Histochemistry"],"original-title":[],"link":[{"URL":"https:\/\/www.ejh.it\/index.php\/ejh\/article\/download\/2665\/2610","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejh.it\/index.php\/ejh\/article\/download\/2665\/2633","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejh.it\/index.php\/ejh\/article\/download\/2665\/2610","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T05:28:03Z","timestamp":1580966883000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejh.it\/index.php\/ejh\/article\/view\/2665"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,2]]},"references-count":0,"URL":"https:\/\/doi.org\/10.4081\/ejh.2016.2665","relation":{},"ISSN":["2038-8306","1121-760X"],"issn-type":[{"value":"2038-8306","type":"electronic"},{"value":"1121-760X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11,2]]},"assertion":[{"value":"2016-04-15","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-11-02","name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}