{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T22:30:33Z","timestamp":1771540233222,"version":"3.50.1"},"reference-count":0,"publisher":"PAGEPress Publications","issue":"4","license":[{"start":{"date-parts":[[2017,10,30]],"date-time":"2017-10-30T00:00:00Z","timestamp":1509321600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2017,10,30]],"date-time":"2017-10-30T00:00:00Z","timestamp":1509321600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":["www.ejh.it"],"crossmark-restriction":true},"short-container-title":["Eur J Histochem"],"abstract":"<jats:p>Pterygium, an ultraviolet radiation (UV)-related disease, is a relatively benign process, but since it displays tumor-like features, it has been proposed to be a neoplastic- like growth disorder. Vitamin D performs a number of functions in addition to calcium homeostasis, as inhibition of cell proliferation, activation of apoptotic pathways, and inhibition of angiogenesis. Since the antitumor actions of vitamin D are mediated primarily through the nuclear vitamin D receptor (VDR), the aim of the present study was to investigate vitamin D status in patients with pterygium and in control subjects, and VDR immunohistochemical expression in samples of pterygium and normal conjunctiva in order to evaluate a possible role of vitamin D pathway in the pathogenesis of the disease. Serum vitamin D concentration was measured among 41 patients with pterygium and 47 volunteers by an automated chemiluminescence immunoassay. Moreover, 23 formalin- fixed and paraffin-embedded pterygium biopsy samples and 24 conjunctiva specimens were treated for the immunohistochemical demonstration of VDR using the streptavidin-biotin alkaline phosphatase method. No differences were observed about vitamin D level between patient with pterygium and control group, but significant differences between VDR immunolocalization in pterygium and normal conjunctiva were observed (P=0.00001). In conjunctiva, the immunoreactivity, localized mainly in cytoplasm of epithelial cells, may probably demonstrate VDR regulation of cell growth, differentiation, and apoptosis, while in pterygium VDR co-localization in the nucleus and cytoplasm of epithelial cells may indicate alternative nuclear pathways by which vitamin D might exert its antiinflammatory and anti-proliferative effects by the regulation of gene expression.<\/jats:p>","DOI":"10.4081\/ejh.2017.2837","type":"journal-article","created":{"date-parts":[[2017,11,2]],"date-time":"2017-11-02T11:43:54Z","timestamp":1509623034000},"update-policy":"https:\/\/doi.org\/10.4081\/ejh.crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Vitamin D and vitamin D receptor in patients with ophthalmic pterygium"],"prefix":"10.4081","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3490-1793","authenticated-orcid":false,"given":"Cristina","family":"Maxia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Murtas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michela","family":"Corrias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignazio","family":"Zucca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Minerba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franca","family":"Piras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristiana","family":"Marinelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Teresa","family":"Perra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2549","published-online":{"date-parts":[[2017,10,30]]},"container-title":["European Journal of Histochemistry"],"original-title":[],"link":[{"URL":"http:\/\/www.ejh.it\/index.php\/ejh\/article\/viewFile\/2837\/2719","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2017,11,20]],"date-time":"2017-11-20T03:24:35Z","timestamp":1511148275000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.ejh.it\/index.php\/ejh\/article\/view\/2837"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,30]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,10,19]]}},"URL":"https:\/\/doi.org\/10.4081\/ejh.2017.2837","relation":{},"ISSN":["2038-8306","1121-760X"],"issn-type":[{"value":"2038-8306","type":"electronic"},{"value":"1121-760X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10,30]]}}}