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Adult rats were treated with letrozole for 6 months and the epididymis weight, morphology, morphometric values and the number of apoptotic cells in \u00a0the epithelium were examined. Long-term aromatase inhibition resulted in presence of intraepithelial clear vacuoles, hyperplasia of clear cells and a hyperplastic alteration in the epithelium known as a cribriform change. Moreover, changes in diameters of the epididymal duct and the epididymal lumen and changes in the epididymal epithelium height were observed. The number of apoptotic epithelial cells was increased in letrozole-treated group. It can be indicated that chronic treatment with letrozole can affect morphology, morphometric values and apoptosis in the epididymis of adult male rats. Observed changes are similar to that observed in the aging processes and may also be important for patients treated with aromatase inhibitors.<\/jats:p>","DOI":"10.4081\/ejh.2021.3259","type":"journal-article","created":{"date-parts":[[2021,9,3]],"date-time":"2021-09-03T06:48:19Z","timestamp":1630651699000},"source":"Crossref","is-referenced-by-count":6,"title":["Morphological and morphometric changes and epithelial apoptosis are induced in the rat epididymis by long-term letrozole treatment"],"prefix":"10.4081","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4955-4437","authenticated-orcid":false,"given":"Anna","family":"Pilutin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7880-7507","authenticated-orcid":false,"given":"Kamila","family":"Misiakiewicz-Has","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2157-0315","authenticated-orcid":false,"given":"Sylwia","family":"Rzeszotek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9064-6969","authenticated-orcid":false,"given":"Barbara","family":"Wiszniewska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2549","published-online":{"date-parts":[[2021,9,3]]},"reference":[{"key":"2350","doi-asserted-by":"crossref","unstructured":"Leir S-H, Browne JA, Eggener SE, Harris A. 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