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Paraffin-embedded biopsies from 289 individuals were examined, including active disease (mild and severe inflammation), upper gastrointestinal involvement, remission and non-inflamed tissue. Expression in epithelial and immune cells was assessed by immunohistochemistry and scored using the Remmele immunoreactive score (IRS). Caspase 3 expression levels in epithelial cells increased in cases of severe inflammation (p=0.012), and immune cells exhibited even more pronounced expression levels (p&lt;0.001). These findings suggest that caspase 3 expression in epithelial and immune cells may help to distinguish between mild and severe inflammation.<\/jats:p>","DOI":"10.4081\/ejh.2026.4570","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T13:35:05Z","timestamp":1780493705000},"source":"Crossref","is-referenced-by-count":0,"title":["Elevated caspase 3 expression correlates with severe inflammation in Crohn\u2019s disease"],"prefix":"10.4081","volume":"70","author":[{"given":"Nafie","family":"Sejdiu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8060-2313","authenticated-orcid":false,"given":"Michael","family":"Naumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Vieth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2549","published-online":{"date-parts":[[2026,6,3]]},"reference":[{"key":"51302","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)02586-2"},{"key":"51303","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-020-00360-x"},{"key":"51304","unstructured":"3. 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