{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:22:23Z","timestamp":1793146943984,"version":"4.5.0"},"reference-count":19,"publisher":"PAGEPress Publications","issue":"3","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Histochem"],"abstract":"<jats:p>Psoriasis\u00a0is a chronic inflammatory skin disease characterized by keratinocyte hyperproliferation and excessive immune activation, for which curative therapies remain limited. This study aimed to investigate the role of small proline-rich protein 2B (SPRR2B) in psoriasis pathogenesis. In this study, gene Expression Omnibus (GEO)\u00a0dataset\u00a0GSE13355\u00a0was\u00a0analyzed using R Language. Cell proliferation, gene and protein expression were measured\u00a0with CCK8, RT-qPCR and immunofluorescence staining, respectively. Bioinformatics analysis of the GSE13355 dataset revealed that SPRR2B was significantly overexpressed in psoriatic lesions and\u00a0was\u00a0positively correlated with immune cell infiltration and multiple inflammatory pathways. In an M5-induced HaCaT keratinocyte psoriatic model, SPRR2B knockdown markedly suppressed cell proliferation and promoted apoptosis via regulation of the MDM2\/p53\/CDKN1A axis. Furthermore, SPRR2B knockdown reduced the secretion of IL-6, IFN-\u03b3, TNF-\u03b1, and IL-1\u03b2, and inhibited JAK1 phosphorylation. These findings demonstrated\u00a0that SPRR2B promotes keratinocyte proliferation and inflammatory response in psoriasis, suggesting it may serve as a promising diagnostic biomarker and therapeutic target for the disease.<\/jats:p>","DOI":"10.4081\/ejh.2026.4606","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T12:14:35Z","timestamp":1786018475000},"source":"Crossref","is-referenced-by-count":1,"title":["SPRR2B knockdown inhibits the proliferation and inflammatory response in M5-treated human HaCaT keratinocytes"],"prefix":"10.4081","volume":"70","author":[{"given":"Zhenzhen","family":"Ding","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengchi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingfeng","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2549","published-online":{"date-parts":[[2026,8,6]]},"reference":[{"key":"52704","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0804595"},{"key":"52705","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61909-7"},{"key":"52706","doi-asserted-by":"publisher","DOI":"10.23736\/S0392-0488.18.06202-8"},{"key":"52707","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.4006"},{"key":"52708","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1993.1240"},{"key":"52709","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1717423115"},{"key":"52710","doi-asserted-by":"publisher","DOI":"10.5483\/BMBRep.2024-0105"},{"key":"52711","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01468-7"},{"key":"52712","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2024.122991"},{"key":"52713","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3337"},{"key":"52714","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.19062"},{"key":"52715","doi-asserted-by":"publisher","DOI":"10.3390\/antiox8110566"},{"key":"52716","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S281032"},{"key":"52717","doi-asserted-by":"publisher","DOI":"10.5114\/ada.2022.113145"},{"key":"52718","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6656622"},{"key":"52719","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2026.1698290"},{"key":"52720","doi-asserted-by":"publisher","DOI":"10.1126\/science.1092472"},{"key":"52721","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1323174"},{"key":"52722","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2024.4433"}],"container-title":["European Journal of Histochemistry"],"original-title":[],"link":[{"URL":"https:\/\/www.ejh.it\/ejh\/article\/download\/4606\/3809","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejh.it\/ejh\/article\/download\/4606\/3810","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ejh.it\/ejh\/article\/download\/4606\/3809","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T06:41:37Z","timestamp":1788331297000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ejh.it\/ejh\/article\/view\/4606"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,6]]},"references-count":19,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,7,23]]}},"URL":"https:\/\/doi.org\/10.4081\/ejh.2026.4606","relation":{},"ISSN":["2038-8306","1121-760X"],"issn-type":[{"value":"2038-8306","type":"electronic"},{"value":"1121-760X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8,6]]}}}