{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:34:07Z","timestamp":1790278447729,"version":"4.1.0"},"reference-count":0,"publisher":"PAGEPress Publications","issue":"4","license":[{"start":{"date-parts":[[2016,9,15]],"date-time":"2016-09-15T00:00:00Z","timestamp":1473897600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Transl Myol"],"abstract":"<jats:p>We have compared the ultrastructure of skeletal muscle biopsies from patients that have survived a [Malignant Hyperthermia, MH] episode and siblings that test positive for MH susceptibility with those from siblings that tested negatives. The aim is to establish whether life long exposure to the MH-related mutation effects may result in subtle abnormalities even in the absence of active episodes and\/or clinically detectable deficiencies. Although a specific ultrastructural signature for MH mutants cannot be demonstrated, an MH related pattern of minor alterations does exist. These include the tendency for micro damage to the contractile apparatus and a higher than normal level of mitochondrial abnormalities.<\/jats:p>","DOI":"10.4081\/ejtm.2016.6105","type":"journal-article","created":{"date-parts":[[2016,11,30]],"date-time":"2016-11-30T11:13:30Z","timestamp":1480504410000},"source":"Crossref","is-referenced-by-count":11,"title":["Skeletal muscle microalterations in patients carrying Malignant Hyperthermia-related mutations of the e-c coupling machinery"],"prefix":"10.4081","volume":"26","author":[{"given":"Manuela","family":"Lavorato","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawan K.","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip M.","family":"Hopkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Franzini-Armstrong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2549","published-online":{"date-parts":[[2016,9,15]]},"container-title":["European Journal of Translational Myology"],"original-title":[],"link":[{"URL":"http:\/\/www.pagepressjournals.org\/index.php\/bam\/article\/viewFile\/6105\/5940","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2016,12,7]],"date-time":"2016-12-07T14:18:11Z","timestamp":1481120291000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.pagepressjournals.org\/index.php\/bam\/article\/view\/6105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,15]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2016,9,15]]}},"URL":"https:\/\/doi.org\/10.4081\/ejtm.2016.6105","relation":{},"ISSN":["2037-7460","2037-7452"],"issn-type":[{"value":"2037-7460","type":"electronic"},{"value":"2037-7452","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9,15]]}}}