{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:58:37Z","timestamp":1790812717889,"version":"4.1.0"},"reference-count":0,"publisher":"PAGEPress Publications","issue":"4","license":[{"start":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T00:00:00Z","timestamp":1573516800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Transl Myol"],"abstract":"<jats:p>The purpose of this study was to examine the effects of exercise in modulating biomarkers of sarcopenia in a treatment na\u00efve transgenic adenocardinoma of the mouse prostate (TRAMP) model. Thirty TRAMP mice were randomized to either exercise (voluntary wheel running) or no-treatment control group for a period of 20 weeks. During necropsy, gastrocnemius muscles and prostate tumors were harvested and weighed. Gastrocnemius concentrations of myostatin, insulin-like growth factor (IGF)-1 and tumor necrosis factor (TNF)-\u03b1 were quantified. Exercise mice had greater muscle mass than controls (p=0.04). Myostatin was significantly lower in the exercise group compared to controls (p=0.01). Exercise mice maintained forelimb grip force while control mice had a significaint decrease (p=0.01). No significant difference was observed in pre-post all limb grip strength. Further, forelimb and all limb grip strength was negatively associated with tumor mass (p&lt;0.01).<\/jats:p>","DOI":"10.4081\/ejtm.2019.8520","type":"journal-article","created":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T16:54:45Z","timestamp":1573577685000},"source":"Crossref","is-referenced-by-count":14,"title":["Exercise preserves muscle mass and force in a prostate cancer mouse model"],"prefix":"10.4081","volume":"29","author":[{"given":"Darpan I.","family":"Patel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kira","family":"Abuchowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bilal","family":"Sheikh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Rivas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Musi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Pratap","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2549","published-online":{"date-parts":[[2019,11,12]]},"container-title":["European Journal of Translational Myology"],"original-title":[],"link":[{"URL":"https:\/\/pagepressjournals.org\/index.php\/bam\/article\/download\/8520\/8455","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pagepressjournals.org\/index.php\/bam\/article\/download\/8520\/8534","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pagepressjournals.org\/index.php\/bam\/article\/download\/8520\/8455","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T00:08:25Z","timestamp":1603930105000},"score":1,"resource":{"primary":{"URL":"https:\/\/pagepressjournals.org\/index.php\/bam\/article\/view\/8520"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,12]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,10,29]]}},"URL":"https:\/\/doi.org\/10.4081\/ejtm.2019.8520","relation":{},"ISSN":["2037-7460","2037-7452"],"issn-type":[{"value":"2037-7460","type":"electronic"},{"value":"2037-7452","type":"print"}],"subject":[],"published":{"date-parts":[[2019,11,12]]}}}