{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:07:22Z","timestamp":1792807642500,"version":"4.5.0"},"reference-count":25,"publisher":"PAGEPress Publications","issue":"1","license":[{"start":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T00:00:00Z","timestamp":1642464000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Transl Myol"],"abstract":"<jats:p>This article was not intended to be a complete review of the electromyography of pathological muscle states, but it was written to illustrate how the \u201cColetti Method of EMG ChemoDenervation\u201d (CMECD\u00ae) protocol for the treatment of chronic pain resulting from chronic muscle spasm was developed and established. That process led to an unexpected understanding of the underlying pathophysiology of chronic muscle spasm, which represents a paradigm shift in our understanding and ultimately in our treatment of muscle spasm-induced chronic pain. Other investigators had brought to light the presence of spontaneous electrical activity (SEA) in states of muscle spasm. Those findings were all but ignored by standard EMG\/Nerve conduction studies in clinical practice. Starting with a simple EMG device I experimented with various medications to treat patients with chronic pain associated with chronic muscle spasm. Suppression of SEA with long-acting medications resolved both the chronic spasm and chronic pain. A successful protocol using phenoxybenzamine was established and clinical outcomes were followed. More than 200 patients were successfully treated during last 12 years. Correlating known exercise muscle physiology with the development of the pathological state of chronic muscle spasm as seen by electromyography led to the postulation of the ischemic model of chronic muscle spasm. Light microscopy pathophysiologic supportive findings are presented and discussed. Predictions from this model to various aspects of treatment were supportive. Implications regarding treatment by the CMECD\uf6da procedure, as well as other standard therapies, are discussed. Application of the ischemic model to other pain conditions was explored with implications of therapeutic modification. Recommendations for changes in rehabilitation therapy are discussed.<\/jats:p>","DOI":"10.4081\/ejtm.2022.10323","type":"journal-article","created":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T15:23:53Z","timestamp":1642519433000},"source":"Crossref","is-referenced-by-count":22,"title":["The ischemic model of chronic muscle spasm and pain"],"prefix":"10.4081","volume":"32","author":[{"given":"Roger H.","family":"Coletti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2549","published-online":{"date-parts":[[2022,1,18]]},"reference":[{"key":"47355","doi-asserted-by":"publisher","DOI":"10.1139\/H09-044"},{"key":"47356","doi-asserted-by":"publisher","DOI":"10.5041\/RMMJ.10336"},{"key":"47357","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0000000000001789"},{"key":"47358","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-004-0069-x"},{"key":"47359","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/59.1.193"},{"key":"47360","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032566"},{"key":"47361","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(02)01472-9"},{"key":"47362","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.015502"},{"key":"47363","doi-asserted-by":"publisher","DOI":"10.4081\/bam.2015.2.109"},{"key":"47364","doi-asserted-by":"publisher","DOI":"10.1016\/j.jevs.2015.08.013"},{"key":"47365","unstructured":"Simons DG. Cardiology and myofascial trigger points: Janet G. Travell's contribution. Tex Heart Inst J. 2003;30(1):3-7."},{"key":"47366","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199310000-00015"},{"key":"47367","doi-asserted-by":"publisher","DOI":"10.1300\/J094v04n01_08"},{"key":"47368","unstructured":"Press Release - University of Calgary. Botulinum toxin A creates muscle weakness and atrophy following long term use, study suggests. ScienceDaily. ScienceDaily, 2 December 2010. www.sciencedaily.com\/releases\/2010\/12\/101202124248.htm."},{"key":"47369","unstructured":"V1: Treatment of IT Band Syndrome with injection of the tensor fascia lata muscle: https :\/\/www.youtube.com\/watch?v=f6npZiwNs7s ."},{"key":"47370","unstructured":"V2: Cessation of SEA with the injection: https:\/\/www.youtube.com\/watch?v=bQrhNlOjOvw."},{"key":"47371","unstructured":"V3: Treatment of chronic back muscle spasm with CMECD\u00ae procedure: https:\/\/www.youtube.com\/ watch?v=fAAfK5n3uP8."},{"key":"47372","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2005.069211"},{"key":"47373","doi-asserted-by":"crossref","unstructured":"Coletti R, Proposd new diagnostic entity of acquired chronic muscle spasm. Abstract in Muscle & Nerve, Volume 58\/ No. S2\/September 2018, Pages: S1-S120; First Published: 02 October 2018, page S34, https:\/\/onlinelibrary.wiley.com\/toc\/1097 4598\/58\/S2.","DOI":"10.1002\/mus.26353"},{"key":"47374","doi-asserted-by":"crossref","unstructured":"Coletti R. EMG guided chemodenervation procedure of acquired chronic muscle spasm designated as CMECD\u00ae. Abstract in Muscle & Nerve, Volume 58\/ No. S2\/September 2018, Pages: S1-S120; First Published: 02 October 2018, Page S36, https:\/\/onlinelibrary.wiley.com\/toc\/10974598\/ 58\/S2.","DOI":"10.1002\/mus.26353"},{"key":"47375","doi-asserted-by":"publisher","DOI":"10.1002\/mus.26353"},{"key":"47376","doi-asserted-by":"publisher","DOI":"10.1002\/mus.26647"},{"key":"47377","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-018-0670-z"},{"key":"47378","doi-asserted-by":"publisher","DOI":"10.3109\/17453679709004002"},{"key":"47379","doi-asserted-by":"publisher","DOI":"10.1002\/ca.20758"}],"container-title":["European Journal of Translational Myology"],"original-title":[],"link":[{"URL":"https:\/\/www.pagepressjournals.org\/index.php\/bam\/article\/download\/10323\/9877","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.pagepressjournals.org\/index.php\/bam\/article\/download\/10323\/9877","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T08:21:41Z","timestamp":1648196501000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.pagepressjournals.org\/index.php\/bam\/article\/view\/10323"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,18]]},"references-count":25,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,3,24]]}},"URL":"https:\/\/doi.org\/10.4081\/ejtm.2022.10323","relation":{},"ISSN":["2037-7460","2037-7452"],"issn-type":[{"value":"2037-7460","type":"electronic"},{"value":"2037-7452","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1,18]]}}}