{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T09:07:31Z","timestamp":1784106451246,"version":"3.55.0"},"reference-count":24,"publisher":"PAGEPress Publications","issue":"1","license":[{"start":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T00:00:00Z","timestamp":1674172800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Transl Myol"],"abstract":"<jats:p>Irisin is an exercise-induced cytokine mainly secreted by myocytes. Circulating level of irisin can increase in response to acute exercise, promoting pleiotropic effects on health. Generally, irisin is evaluated in blood, however, its collection is invasive. Saliva sample would not have any risk associated with blood collection and would represent a less invasive method for irisin detection. Until now, there are only a few studies that have analyzed irisin levels in saliva. In the present research, five healthy male adults performed an incremental exercise until exhaustion on cycle ergometer. Serum and saliva samples were collected before exercise and 15min, 24h and 48h after reaching the exhaustion. Irisin was detected by ELISA assay. Serum and salivary irisin levels increased from baseline to 24h post exercise and reverted to basal levels after 48h of rest. A significant rise of both serum and salivary irisin level at 24h (p\u22640.05) compared to baseline levels was found. Furthermore, a significant correlation between irisin percentage change in serum and saliva from baseline to 24h post exercise was detected (r=0.92, p&lt;0.05). Despite the relatively limited sample, this research suggests that collecting saliva samples might represent a valid and less invasive method to detect irisin level changes induced by exercise.<\/jats:p>","DOI":"10.4081\/ejtm.2023.11093","type":"journal-article","created":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T12:58:27Z","timestamp":1674219507000},"source":"Crossref","is-referenced-by-count":21,"title":["Salivary and serum irisin in healthy adults before and after exercise"],"prefix":"10.4081","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6551-6698","authenticated-orcid":false,"given":"Sara","family":"Missaglia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2796-0688","authenticated-orcid":false,"given":"Ester","family":"Tommasini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Vago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Pecci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0126-6033","authenticated-orcid":false,"given":"Christel","family":"Galvani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2005-3746","authenticated-orcid":false,"given":"Andrea","family":"Silvestrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3260-9796","authenticated-orcid":false,"given":"Alvaro","family":"Mordente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3333-0068","authenticated-orcid":false,"given":"Daniela","family":"Tavian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2549","published-online":{"date-parts":[[2023,1,20]]},"reference":[{"key":"68049","doi-asserted-by":"publisher","DOI":"10.1038\/nature10777"},{"key":"68050","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.962968"},{"key":"68051","doi-asserted-by":"publisher","DOI":"10.2174\/1389203723666220217141918"},{"key":"68052","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2012.49"},{"key":"68053","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.21636"},{"key":"68054","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01131-0"},{"key":"68055","doi-asserted-by":"publisher","DOI":"10.1111\/sms.12904"},{"key":"68056","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/246178"},{"key":"68057","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.4807861"},{"key":"68058","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199223050-00003"},{"key":"68059","doi-asserted-by":"publisher","DOI":"10.1080\/10253890.2022.2156783"},{"key":"68060","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2013.09.011"},{"key":"68061","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2014.04.002"},{"key":"68062","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0136864"},{"key":"68063","doi-asserted-by":"publisher","DOI":"10.4137\/BCI.S39671"},{"key":"68064","unstructured":"Altay DU, Korkmaz M, Ergun S, Korkmaz H, Noyan T. Salivary irisin: potential inflammatory biomarker in recurrent apthous stomatitis patients. Eur Rev Med Pharmacol Sci. 2021 Mar;25(5):2252-2259."},{"key":"68065","unstructured":"Khan SU, Ghafoor S, Khaliq S, Syed AR. Salivary Irisin and periodontal clinical parameters in patients of chronic periodontitis and healthy individuals: A novel salivary myokine for periodontal disease. J Pak Med Assoc. 2022 Jan;72(1):27-33."},{"key":"68066","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-21131-4"},{"key":"68067","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2017.00077"},{"key":"68068","unstructured":"Gordon CC, Chumlea WC, Roche AF. Stature, recumbent length and weight. In: Lohman TG, Roche AF, Martorell R, eds. Anthropometric standardization reference manual. 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