{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T04:22:12Z","timestamp":1778732532961,"version":"3.51.4"},"reference-count":8,"publisher":"PAGEPress Publications","issue":"3","license":[{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Transl Myol"],"abstract":"<jats:p>Tessitore, Costelli\u00a0et al. were among the first to report a previously unnoticed loss of heart mass in cachectic mice suffering from a severe tumor burden. At the time both the general consensus definition of cachexia\u00a0and the cancer cachexia classification\u00a0did not exist. In particular, cancer cachexia is a syndrome characterized by muscle wasting leading to body weight loss in the presence of cancer. More recently, Zhou\u00a0et al. highlighted once more the existence of a tumor-induced loss of heart mass in a murine model of cancer cachexia. This study generated a new line of research aimed at exploring the mechanisms underlying cardiac wasting in the presence of cancer. Cardiac wasting in the presence of cancer-induced cachexia is distinct from and other than cardiac cachexia, i.e. the atrophy of skeletal muscle induced by cardiac pathologies. However, over the years we have noticed that expressions such as \u201ccardiac cachexia\u201d, \u201ccardiac atrophy\u201d, and \u201cmuscle cachexia\u201d\u00a0 - that sound alike but are very different - are often mistakenly used. In particular, we are afraid that these misunderstandings may suggest to inexperienced readers that cardiac cachexia is a form of cardiac muscle atrophy, which is not. To add insult to injury, some authors use the expression \u201cmuscle cachexia\u201d meaning muscle atrophy, which, as a consequence, may suggest to naive readers that cardiac cachexia is a form of cardiac muscle atrophy. We aim here to clarify the terminology describing these conditions, so as to avoid the misleading use of related expressions: cardiac atrophy and cardiac cachexia may sound alike but are very different. In particular, it is the expression \u201ccardiac cachexia\u201d that raises a problem of ambiguity and should be handled with care. [...]<\/jats:p>","DOI":"10.4081\/ejtm.2025.14147","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T12:07:22Z","timestamp":1756814842000},"source":"Crossref","is-referenced-by-count":1,"title":["Cardiac wasting is not cardiac cachexia: the problem of the subjective\/objective genitive in matters of the heart"],"prefix":"10.4081","volume":"35","author":[{"given":"Anna Luisa","family":"Mazzotti","sequence":"first","affiliation":[{"name":"Assointerpreti, Italian Association of Conference Interpreters, Rome, Italy, and MPS Public Speaking Rome"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Medhi","family":"Hassani","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Institut de Biologie Paris-Seine (IBPS), UMR CNRS 8263, INSERM U1345, Development, Adaptation and Ageing, Paris, France; Unit of Histology and Medical Embryology, Department of Anatomy, Histology, Forensic Medicine and Orthopedics, Sapienza University of Rome, Rome, Italy; Interuniversity Institute of Myology, Rome, Italy; Universit\u00e9 de Brest, Brest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenlin","family":"Li","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Institut de Biologie Paris-Seine (IBPS), UMR CNRS 8263, INSERM U1345, Development, Adaptation and Ageing, Paris"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise","family":"Paulin","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Institut de Biologie Paris-Seine (IBPS), UMR CNRS 8263, INSERM U1345, Development, Adaptation and Ageing, Paris"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Onnik","family":"Agbulut","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Institut de Biologie Paris-Seine (IBPS), UMR CNRS 8263, INSERM U1345, Development, Adaptation and Ageing, Paris"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7373-1953","authenticated-orcid":true,"given":"Dario","family":"Coletti","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Institut de Biologie Paris-Seine (IBPS), UMR CNRS 8263, INSERM U1345, Development, Adaptation and Ageing, Paris, France; Unit of Histology and Medical Embryology, Department of Anatomy, Histology, Forensic Medicine and Orthopedics, Sapienza University of Rome, Rome, Italy; Interuniversity Institute of Myology, Rome"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2549","published-online":{"date-parts":[[2025,9,2]]},"reference":[{"key":"192392","doi-asserted-by":"crossref","unstructured":"1 Tessitore L, Costelli P, Bonetti G, Baccino FM. Cancer cachexia, malnutrition, and tissue protein turnover in experimental animals. Arch Biochem Biophys 1993;306:52-8.","DOI":"10.1006\/abbi.1993.1479"},{"key":"192393","doi-asserted-by":"crossref","unstructured":"2 Evans WJ, Morley JE, Argil\u00e9s J, et al. Cachexia: a new definition. Clin Nutr 2008;27:793-9.","DOI":"10.1016\/j.clnu.2008.06.013"},{"key":"192394","doi-asserted-by":"crossref","unstructured":"3 Fearon K, Strasser F, Anker SD, et al. Definition and classification of cancer cachexia: an international consensus. Lancet Oncol 2011;12:489-95.","DOI":"10.1016\/S1470-2045(10)70218-7"},{"key":"192395","doi-asserted-by":"crossref","unstructured":"4 Benoni A, Renzini A, Cavioli G, Adamo S. Neurohypophyseal hormones and skeletal muscle: a tale of two faces. Eur J Transl Myol 2020;30:8899.","DOI":"10.4081\/ejtm.2019.8899"},{"key":"192396","doi-asserted-by":"crossref","unstructured":"5 Scicchitano BM, Bouch\u00e8 M, Nervi C, Coletti D. A tribute to Professor Sergio Adamo, Full Professor of Histology and Embryology at Sapienza University, Rome. Eur J Transl Myol 2022; 32:10434.","DOI":"10.4081\/ejtm.2022.10434"},{"key":"192397","doi-asserted-by":"crossref","unstructured":"6 Zhou X, Wang JL, Lu J, et al. Reversal of cancer cachexia and muscle wasting by ActRIIB antagonism leads to prolonged survival. Cell 2010;142:531-43.","DOI":"10.1016\/j.cell.2010.07.011"},{"key":"192398","doi-asserted-by":"crossref","unstructured":"7 Loncar G, Springer J, Anker M, et al. Cardiac cachexia: hic et nunc. J Cachexia Sarcopenia Muscle 2016;7:246-60.","DOI":"10.1002\/jcsm.12118"},{"key":"192399","doi-asserted-by":"crossref","unstructured":"8 Mitch WE, Price SR. Transcription factors and muscle cachexia: is there a therapeutic target? Lancet 2001;357:734-5.","DOI":"10.1016\/S0140-6736(00)04177-5"}],"container-title":["European Journal of Translational Myology"],"original-title":[],"link":[{"URL":"https:\/\/www.pagepressjournals.org\/bam\/article\/download\/14147\/13354","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.pagepressjournals.org\/bam\/article\/download\/14147\/13492","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.pagepressjournals.org\/bam\/article\/download\/14147\/13354","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T09:40:27Z","timestamp":1769679627000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.pagepressjournals.org\/bam\/article\/view\/14147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,2]]},"references-count":8,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,10,2]]}},"URL":"https:\/\/doi.org\/10.4081\/ejtm.2025.14147","relation":{},"ISSN":["2037-7460","2037-7452"],"issn-type":[{"value":"2037-7460","type":"electronic"},{"value":"2037-7452","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9,2]]}}}