{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T23:57:01Z","timestamp":1789516621023,"version":"build-2803163510"},"reference-count":0,"publisher":"PAGEPress Publications","issue":"1","license":[{"start":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T00:00:00Z","timestamp":1557792000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Geospat Health"],"abstract":"<jats:p>Lyme disease (LD) is the most common vector-borne disease in the United States. Early confirmatory diagnosis remains a challenge, while the disease can be debilitating if left untreated. Further, the decision to test is complicated by under-reporting, low positive predictive values of testing in non-endemic areas and travel, which together exacerbate the difficulty in identification of newly endemic areas or areas of emerging concern. Spatio-temporal analyses at the national scale are critical to establishing a baseline human LD risk assessment tool that would allow for the detection of changes in these areas. A well-established surrogate for human LD incidence is canine LD seroprevalence, making it a strong candidate covariate for use in such analyses. In this paper, Bayesian statistical methods were used to fit a spatio-temporal spline regression model to estimate the relationship between human LD incidence and canine seroprevalence, treating the latter as an explanatory covariate. A strong non-linear monotonically increasing association was found. That is, this analysis suggests that mean incidence in humans increases with canine seroprevalence until the seroprevalence in dogs reaches approximately 30%. This finding reinforces the use of canines as sentinels for human LD risk, especially with respect to identifying geographic areas of concern for potential human exposure.<\/jats:p>","DOI":"10.4081\/gh.2019.750","type":"journal-article","created":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T17:19:45Z","timestamp":1557854385000},"source":"Crossref","is-referenced-by-count":38,"title":["Quantifying the relationship between human Lyme disease and Borrelia burgdorferi exposure in domestic dogs"],"prefix":"10.4081","volume":"14","author":[{"given":"Yan","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shila K.","family":"Nordone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Yabsley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert B.","family":"Lund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher S.","family":"McMahan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenna R.","family":"Gettings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2549","published-online":{"date-parts":[[2019,5,14]]},"container-title":["Geospatial Health"],"original-title":[],"link":[{"URL":"https:\/\/geospatialhealth.net\/index.php\/gh\/article\/download\/750\/774","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/geospatialhealth.net\/index.php\/gh\/article\/download\/750\/797","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/geospatialhealth.net\/index.php\/gh\/article\/download\/750\/773","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,23]],"date-time":"2020-04-23T03:30:00Z","timestamp":1587612600000},"score":1,"resource":{"primary":{"URL":"https:\/\/geospatialhealth.net\/index.php\/gh\/article\/view\/750"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,14]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,5,14]]}},"URL":"https:\/\/doi.org\/10.4081\/gh.2019.750","relation":{},"ISSN":["1970-7096","1827-1987"],"issn-type":[{"value":"1970-7096","type":"electronic"},{"value":"1827-1987","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5,14]]}}}