{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:43:17Z","timestamp":1761129797077,"version":"3.37.3"},"reference-count":38,"publisher":"PAGEPress Publications","issue":"2","license":[{"start":{"date-parts":[[2021,1,11]],"date-time":"2021-01-11T00:00:00Z","timestamp":1610323200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Geospat Health"],"abstract":"<jats:p>Visceral Leishmaniasis (VL) is a neglected disease with increasing incidence in Brazil, particularly in the North-eastern. The aim of this study was to analyze the spatial and spatiotemporal dynamics of VL in an endemic region of North-eastern Brazil, between 2009 and 2017. Using spatial analysis techniques, an ecological and time series study was made regarding VL cases in Sergipe filed as notifiable disease events. With data from the Brazilian Institute of Geography and Statistics (Instituto Brasileiro de Geografia e Estat\u00edstica, IBGE), a digital population and cartographic baseline was established. Segmented linear regression was used to examine the temporal trends. The statistical analysis methods of Global and Local Moran\u2019 I, local Bayesian empirical methodology and spatial-temporal scanning were used to produce thematic maps. High instances were found among adults, males, urban residents, non-Whites and persons with low levels of education. A decrease in the recovery rate and an increase in the proportion of urban cases and lethality was found. A heterogeneous VL distribution with spatiotemporal agglomeration on the seaside of the state was seen in Sergipe. To better manage the disease, new research is encouraged together with development of public health strategies. Further, improving health care networks, especially primary care, is suggested as this approach has a key role in health promotion, prevention and monitoring of the most prevalent diseases.<\/jats:p>","DOI":"10.4081\/gh.2020.885","type":"journal-article","created":{"date-parts":[[2021,1,11]],"date-time":"2021-01-11T11:30:18Z","timestamp":1610364618000},"source":"Crossref","is-referenced-by-count":3,"title":["Spatial and spatiotemporal dynamics of visceral leishmaniasis in an endemic North-eastern region of Brazil"],"prefix":"10.4081","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0813-6861","authenticated-orcid":false,"given":"\u00c2ndria Silveira","family":"Almeida","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9767-3938","authenticated-orcid":false,"given":"Ca\u00edque Jordan Nunes","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8812-3686","authenticated-orcid":false,"given":"Camila Caroline","family":"Carlini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4990-3257","authenticated-orcid":false,"given":"Rog\u00e9rio Silva","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6529-1887","authenticated-orcid":false,"given":"Allan Dantas","family":"Dos Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5452-0771","authenticated-orcid":false,"given":"D\u00e9bora Santos","family":"Tavares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4433-5227","authenticated-orcid":false,"given":"Karina Concei\u00e7\u00e3o Gomes Machado","family":"De Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana Rodrigues de","family":"Moura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8863-5718","authenticated-orcid":false,"given":"Priscila Lima dos","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2549","published-online":{"date-parts":[[2021,1,11]]},"reference":[{"key":"185","unstructured":"Anselin L. Exploring Spatial Data with GeoDaTM: A Workbook, 2005. 1. ed. Urbana: Center for Spatially Integrated Social Science, 36 pp."},{"key":"186","doi-asserted-by":"crossref","unstructured":"Antunes JLF; Cardoso MRA, 2015. Using time series analysis in epidemiological studies. Epidemiol Serv Sa\u00fade 24:565\u2013576.","DOI":"10.5123\/S1679-49742015000300024"},{"key":"187","doi-asserted-by":"crossref","unstructured":"Assun\u00e7\u00e3o, RM, Barreto SM, Guerra HL, Sakurai E, 1998. Mapas de taxas epidemiol\u00f3gicas: uma abordagem Bayesiana. Cad Sa\u00fade P\u00fablica 14:713\u2013723.","DOI":"10.1590\/S0102-311X1998000400013"},{"key":"188","doi-asserted-by":"crossref","unstructured":"Barbosa DS, Belo VS, Rangel MES, Werneck GL, 2013. Spatial analysis for identification of priority areas for surveillance and control in a visceral leishmaniasis endemic area in Brazil. Science 131:56\u201362.","DOI":"10.1016\/j.actatropica.2013.12.002"},{"key":"189","doi-asserted-by":"crossref","unstructured":"Bezerra JMT, de Ara\u00fajo VEM, Barbosa DS, Martins-Melo FR, Werneck GL, Carneiro M, 2016. Burden of leishmaniasis in Brazil and federated units, 1990-2016: Findings from Global Burden of Disease Study. PLoS Negl Trop Dis 12: e0006697.","DOI":"10.1371\/journal.pntd.0006697"},{"key":"190","doi-asserted-by":"crossref","unstructured":"Boaz R, Corber\u00e1n-Vallet A, Lawson A, de Ferreira-Lima FE, Donato LE, Alves RV, et al., 2019. Integration of animal health and public health surveillance sources to exhaustively inform the risk of zoonosis: An application to visceral leishmaniasis data in Brazil. Spat Spatiotemporal Epidemiol 29:177\u201385.","DOI":"10.1016\/j.sste.2018.09.001"},{"key":"191","doi-asserted-by":"crossref","unstructured":"Boelaert M, Meheus F, Sanchez A, Singh SP, Vanlerberghe V, Picado A, Meessen B, Sundar S, 2009.The poorest of the poor: A poverty appraisal of households affected by visceral leishmaniasis in Bihar, India. Trop Med Int Health 14:639\u2013644.","DOI":"10.1111\/j.1365-3156.2009.02279.x"},{"key":"192","doi-asserted-by":"crossref","unstructured":"Campos RNS, Tunon GIL, Cunha LCS, Magalhaes LS, Moraes J, Ramalho D, Lima S, Pacheco J, Lipscomb M, Jesus AR, Almeida RP, 2017. Epidemiological aspects and spatial distribution of human and canine visceral leishmaniasis in an endemic area in northeastern Brazil. Geospatial Healt 12:67-73.","DOI":"10.4081\/gh.2017.503"},{"key":"193","doi-asserted-by":"crossref","unstructured":"Cavalcante FRA, Cavalcante KKS, Florencio CMGD, Moreno JO, Correia FGS, Alencar CH, 2019. Human visceral leishmaniasis: epidemiological, temporal and spacial aspects in Northeast Brazil, 2003-2017. Rev Inst Med Trop S\u00e3o Paulo 62:e12.","DOI":"10.1590\/s1678-9946202062012"},{"key":"194","doi-asserted-by":"crossref","unstructured":"Costa de Albuquerque MA, Dias DM, Vieira LT, Lima CA, Silva AM, 2017. Mortality trends for Neglected Tropical Diseases in the State of Sergipe, Brazil, 1980-2013. Infect Dis Poverty 8:6-20.","DOI":"10.1186\/s40249-016-0232-8"},{"key":"195","doi-asserted-by":"crossref","unstructured":"Costa DNCC, Bermudi PMM, Rodas LAC, Nunes CM, Hiramoto RM, Tolezano JE, Cipriano RS, Cardoso GCD, Code\u00e7o CT, Neto FC, 2018. Human visceral leishmaniasis and relationship with vector and canine control measures. Rev Sa\u00fade P\u00fablica 52:1\u201311.","DOI":"10.11606\/S1518-8787.2018052000381"},{"key":"196","doi-asserted-by":"crossref","unstructured":"da Rocha ICM, dos Santos LHM, Coura-Vital W, da Cunha GMR, Magalh\u00e3es FC, da Silva TAM, Morais MHF, Oliveira E, Reis IA, Carneiro M, 2018. Effectiveness of the Brazilian Visceral Leishmaniasis Surveillance and Control Programme in reducing the prevalence and incidence of Leishmania infantum infection. Parasit Vectors 12:11-586.","DOI":"10.1186\/s13071-018-3166-0"},{"key":"197","unstructured":"DATASUS, 2019. Department of Informatics of the Unified Health Systems. Available from: http:\/\/datasus.saude.gov.br\/informacoes-de-saude."},{"key":"198","doi-asserted-by":"crossref","unstructured":"de Souza CDF, Rocha VS, Santos NF, Leal TC, de Paiva JPS, Oliveira CCC, Martins-Filho PRS, Magalh\u00e3es MAFM, Cuevas LE, Santos VS, 2019. Spatial clustering, social vulnerability and risk of leprosy in an endemic area in Northeast Brazil: an ecological study. J Eur Acad Dermatol Venereol 33:1581\u20131590.","DOI":"10.1111\/jdv.15596"},{"key":"199","doi-asserted-by":"crossref","unstructured":"dos Santos AD, Lima ACR, Santos MB, Alves JAB, G\u00f3es MAO, Nunes MAP, S\u00e1 SLCS, de Ara\u00fajo KCGM, 2019. Spatial analysis for the identification of risk areas for schistosomiasis mansoni in the State of Sergipe, Brazil, 2005-2014. Rev Soc Bras Med Trop 49:608-615.","DOI":"10.1590\/0037-8682-0137-2016"},{"key":"200","doi-asserted-by":"crossref","unstructured":"G\u00f3es MAO, Melo CMD, Jeraldo VDLS, 2012. S\u00e9rie temporal da leishmaniose visceral em Aracaju, estado de Sergipe, Brasil (1999 a 2008): aspectos humanos e caninos. Rev Bras Epidemiol15:298-307.","DOI":"10.1590\/S1415-790X2012000200007"},{"key":"201","unstructured":"G\u00f3es MAO, Jeraldo VDLS, 2013. Caracter\u00edsticas cl\u00ednicas e epidemiol\u00f3gicas dos pacientes internados com leishmaniose visceral em hospital de refer\u00eancia. Rev Soc Bras Clin Med 11:227-231."},{"key":"202","doi-asserted-by":"crossref","unstructured":"G\u00f3es MAO, Jeraldo VLS, Oliveira AS, 2014. Urbaniza\u00e7\u00e3o da leishmaniose visceral: aspectos cl\u00ednicos e epidemiol\u00f3gicos em Aracaju, Sergipe, Brasil. Rev Bras Med Fam Comunidade 9:119-126.","DOI":"10.5712\/rbmfc9(31)685"},{"key":"203","doi-asserted-by":"crossref","unstructured":"Gontijo CMF, Melo MN, 2004. Leishmaniose Visceral no Brasil. Rev Bras Epidemiol 7:7-12.","DOI":"10.1590\/S1415-790X2004000300011"},{"key":"204","doi-asserted-by":"crossref","unstructured":"Hailu T, Yimer M, Mulu W, Abera B, 2016. Challenges in visceral leishmaniasis control and elimination in the developing countries: A review. J Vector Borne Dis 53:193\u2013198.","DOI":"10.4103\/0972-9062.191335"},{"key":"205","unstructured":"IBGE, 2019. Instituto Brasileiro de Geografia e Estat\u00edstica. Avaliable from: http:\/\/www.ibge.gov.br. Accessed: Sep 7, 2019."},{"key":"206","doi-asserted-by":"crossref","unstructured":"Kulldorff MA, 1997. Spatial scan statistic. Commun Stat Theory Methods, 26:1481\u20131496.","DOI":"10.1080\/03610929708831995"},{"key":"207","unstructured":"Lane VM, 2016. An\u00e1lise epidemiol\u00f3gica da Leishmaniose visceral humana no Brasil: contribui\u00e7\u00e3o as pol\u00edticas de controle. Reposit\u00f3rio UNB, Bras\u00edlia, 25 pp."},{"key":"208","doi-asserted-by":"crossref","unstructured":"Lima ID, Lima ALM, Mendes-Aguiar CO, Coutinho JFV, Wilson ME, Pearson RD, Queiroz JW, Jeronimo SMB, 2018. Changing demographics of visceral leishmaniasis in northeast Brazil: Lessons for the future. PLoS Negl Trop Dis 12:e0006164.","DOI":"10.1371\/journal.pntd.0006164"},{"key":"209","doi-asserted-by":"crossref","unstructured":"Lima SVMA, dos Santos AD, Duque AM, G\u00f3es MAO, Peixoto MVS, Ara\u00fajo DC, Ribeiro CJN, Santos MB, de Ara\u00fajo KCGM, Nunes MAP, 2019. Spatial and temporal analysis of tuberculosis in an area of social inequality in Northeast Brazil. BMC Public Health 19:1\u20139.","DOI":"10.1186\/s12889-019-7224-0"},{"key":"210","doi-asserted-by":"crossref","unstructured":"Mendes CS, Coelho AB, F\u00e9res JG, de Souza EC, da Cunha DA., 2016. The impact of climate change on leishmaniasis in Brazil. Ci\u00eancia & Sa\u00fade Coletiva 21:263-272.","DOI":"10.1590\/1413-81232015211.03992015"},{"key":"211","unstructured":"Ministry of Health, 2019. Guide to Health Surveillance. 3. ed. Bras\u00edlia: Minist\u00e9rio da Sa\u00fade."},{"key":"212","unstructured":"Ministry of Health, 2017. Minist\u00e9rio da Sa\u00fade. Leishmaniose Visceral. Secretaria de Vigil\u00e2ncia em Sa\u00fade. Departamento de Vigil\u00e2ncia Epidemiol\u00f3gica. Coordena\u00e7\u00e3o Geral de Doen\u00e7as Transmiss\u00edveis. Outubro, 2017."},{"key":"213","doi-asserted-by":"crossref","unstructured":"Nunes BEBR, Leal TC, de Paiva JPS, da Silva LF, do Carmo RF, Machado MF, Araujo MDP, Santos VS, de Souza CD, 2020. Social determinants of mortality due to visceral leishmaniasis in Brazil (2001-2015): an ecological study. Rev Soc Bras Med Trop 53:e20190262.","DOI":"10.1590\/0037-8682-0262-2019"},{"key":"214","doi-asserted-by":"crossref","unstructured":"Romero GAS, Boelaert M, 2010. Control of visceral leishmaniasis in Latin America - A systematic review. PLoS Negl Trop Dis 4:e584.","DOI":"10.1371\/journal.pntd.0000584"},{"key":"215","doi-asserted-by":"crossref","unstructured":"Santos GO, de Jesus NPS, Cerqueira-Braz JV, Santos VS, de Lemos LMD, de Santos GO, 2019. Prevalence of HIV and associated factors among visceral leishmaniasis cases in an endemic area of Northeast Brazil. Rev Soc Bras Med Trop 52: e20180257.","DOI":"10.1590\/0037-8682-0257-2018"},{"key":"216","doi-asserted-by":"crossref","unstructured":"Santos MA, Rodrigues SLC, Nascimento ALF, Rodrigues JS, G\u00f3es MAO, 2018. Leishmaniose Visceral: Caracter\u00edsticas cl\u00ednico-epidemiol\u00f3gicas de casos e \u00f3bitos no estado de Sergipe. Rev Epidemiol Controle Infec\u00e7 8:428-434.","DOI":"10.17058\/reci.v8i4.11591"},{"key":"217","unstructured":"Sena IVDO, 2015. Fatores associados ao \u00f3bito por leishmaniose visceral em hospital p\u00fablico de refer\u00eancia no estado do Piau\u00ed. Acervo FIOCRUZ 616.9364098122, 52 pp."},{"key":"218","doi-asserted-by":"crossref","unstructured":"Sousa JMS, Ramalho WM, Melo MA, 2018. Demographic and clinical characterization of human visceral leishmaniasis in the State of Pernambuco, Brazil between 2006 and 2015.Rev Soc Bras Med Trop 51:622-630.","DOI":"10.1590\/0037-8682-0047-2018"},{"key":"219","unstructured":"Sousa S, Hachmann CM, Winck, CA, 2018. Leishmaniose visceral canina: revis\u00e3o de literatura. Unincor 6:1-12."},{"key":"220","doi-asserted-by":"crossref","unstructured":"Toledo CRS, Almeida AS, Chaves SAM, Sabroza P, Toledo LM, Caldas JP, 2017. Vulnerability to the transmission of human visceral leishmaniasis in a Brazilian urban area. Rev Sa\u00fade P\u00fablica 1:49-51.","DOI":"10.1590\/s1518-8787.2017051006532"},{"key":"221","doi-asserted-by":"crossref","unstructured":"Werneck GL, 2016. Controle da leishmaniose visceral no Brasil: o fim de um ciclo? Cad Sa\u00fade P\u00fablica 32:1-2.","DOI":"10.1590\/0102-311X00ED010616"},{"key":"222","unstructured":"World Health Organization, 2015. Working to overcome the global impact of neglected tropical diseases: first WHO report on neglected tropical diseases. Geneva: World Health Organization."}],"container-title":["Geospatial Health"],"original-title":[],"link":[{"URL":"https:\/\/geospatialhealth.net\/index.php\/gh\/article\/download\/885\/932","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/geospatialhealth.net\/index.php\/gh\/article\/download\/885\/932","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T05:07:48Z","timestamp":1724303268000},"score":1,"resource":{"primary":{"URL":"https:\/\/geospatialhealth.net\/index.php\/gh\/article\/view\/885"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,11]]},"references-count":38,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,11,26]]}},"URL":"https:\/\/doi.org\/10.4081\/gh.2020.885","relation":{},"ISSN":["1970-7096","1827-1987"],"issn-type":[{"type":"electronic","value":"1970-7096"},{"type":"print","value":"1827-1987"}],"subject":[],"published":{"date-parts":[[2021,1,11]]}}}