{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:57:23Z","timestamp":1766451443096},"reference-count":10,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2010,12,22]],"date-time":"2010-12-22T00:00:00Z","timestamp":1292976000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematology Reports"],"abstract":"<jats:p>Klinefelter\u2019s syndrome is characterized by abnormal karyotype 47, XXY and a phenotype associated with hypogonadism and gynecomastia. Often the disease can be diagnosed accidentally, when carrying out cytogenetic analysis in cases of a malignant blood disease. We present the clinical case of a patient diagnosed with acute myelomonoblastic leukemia- M4 Eo (AML- M4), where by means of classic cytogenetics a karyotype was found corre-sponding to Klinefelter\u2019s syndrome. Three induction courses of polychemotherapy wermade, which led to remission of the disease, documented both flowcytometrically and cytogenetically.<\/jats:p>","DOI":"10.4081\/hr.2010.e11","type":"journal-article","created":{"date-parts":[[2011,2,17]],"date-time":"2011-02-17T15:50:29Z","timestamp":1297957829000},"page":"e11","source":"Crossref","is-referenced-by-count":2,"title":["Clinical Case of Acute Myeloblastic Leukemia with t(8;21)(q22;q22) in a Patient with Klinefelter\u2019s Syndrome"],"prefix":"10.3390","volume":"2","author":[{"given":"Vanya","family":"Slavcheva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tzvetan","family":"Lukanov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gueorgui","family":"Balatsenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svetlana","family":"Angelova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Antonov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lachezar","family":"Bogdanov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolay","family":"Tsvetkov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2010,12,22]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1093\/jnci\/dji240","article-title":"Cancer incidence and mortality in men with Klinefelter syndrome: a cohort study","volume":"97","author":"Swerdlow","year":"2005","journal-title":"Journal of the National Cancer Institute"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s00277-002-0430-2","article-title":"Agnogenic myeloid metaplasia associated with Klinefelter syndrome: a case report","volume":"81","author":"Kumar","year":"2002","journal-title":"Ann Hematol"},{"key":"ref3","first-page":"1512","article-title":"Phenotype manifestation of polysomy X at males","volume":"2","author":"Catovic","year":"1998","journal-title":"Bosnian journal of basic medical sciences"},{"key":"ref4","first-page":"158","article-title":"Acute lymphoblastic leukemia","author":"Provan","year":"2004","journal-title":"Oxford Handbook of clinical haematology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3109\/08880019209006400","article-title":"Acute Lymphoblastic Leukemia and Klinefelter's Syndrome","volume":"9","author":"Shaw","year":"1992","journal-title":"Pediatr Hematol Oncol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"132","DOI":"10.3122\/jabfm.18.2.132","article-title":"Unsuspected Klinefelter syndrome diagnosed during oncologic evaluation: a Case Series","volume":"18","author":"Eberl","year":"2005","journal-title":"JABFP"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/bjc.1995.85","article-title":"Cancer incidence in men withKlinefelter syndrome","volume":"71","author":"Hasle","year":"1995","journal-title":"Br J Cancer"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1038\/sj.leu.2401592","article-title":"Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in acute leukemia for detection of minimal residual disease. 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