{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:33:27Z","timestamp":1761896007700},"reference-count":14,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2011,10,11]],"date-time":"2011-10-11T00:00:00Z","timestamp":1318291200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematology Reports"],"abstract":"<jats:p>We present for the first time a 40-year-old male patient with a 20 year history of occupational exposure to radiation as a nuclear power plant worker, who developed FIP1L1-PDGFRA-positive chronic eosinophilic leukaemia  27 months after radiotherapy for testicular seminoma.  After an one-year history of dry cough, itching and night sweats, the patient presented with an elevated leukocyte count with absolute eosinophilia of 14.2 \u00d7 109\/L, bone marrow and lymph node involvement. Treatment with Imatinib was initiated, resulting in complete haematological remission at the sixth month and complete molecular response by nested primers reverse transcription polymerase chain reaction\u2013at the end of the first year. This case contributes for the clinical heterogeneity of FIP1L1-PDGFA\u2013positive myeloproliferative neoplasms and the possible role of occupational and therapeutic radiation, raising the question if one or both of them might be the causative factor.<\/jats:p>","DOI":"10.4081\/hr.2011.e17","type":"journal-article","created":{"date-parts":[[2015,1,15]],"date-time":"2015-01-15T13:00:01Z","timestamp":1421326801000},"page":"e17","source":"Crossref","is-referenced-by-count":2,"title":["Chronic Eosinophilic Leukemia with FIP1L1-PDGFRA Transcripts after Occupational and Therapeutic Exposure to Radiation"],"prefix":"10.3390","volume":"3","author":[{"given":"Gueorgui","family":"Balatzenko","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolay","family":"Stoyanov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Bekrieva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margarita","family":"Guenova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2011,10,11]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"3759","DOI":"10.1158\/0008-5472.CAN-06-4183","article-title":"Molecular mechanisms underlying FIP1L1-PDGFRA-mediated myeloproliferation","volume":"67","author":"Buitenhuis","year":"2007","journal-title":"Cancer research"},{"key":"ref2","series-title":"WHO classification of tumors of haematopoieitic and lymphoid tissues","first-page":"68","article-title":"Myeloid and lymphoid neoplasms with eosinophilia and abnormities of PDGFRA, PDGFRB and FGFR1","author":"Bain","year":"2008"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1532\/IJH97.05048","article-title":"Chronic eosinophilic leukemia with the FIP1L1-PDGFRalpha fusion gene in a patient with a history of combination chemo-therapy","volume":"83","author":"Tanaka","year":"2006","journal-title":"Int J Hematol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1634\/theoncologist.2008-0057","article-title":"Is there an entity of chemically induced BCR-ABL-positive chronic myelogenous leukemia?","volume":"13","author":"Lichtman","year":"2008","journal-title":"Oncologist"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1093\/jnci\/djm081","article-title":"Comparative mortality for 621 second cancers in 29356 testicular cancer survivors and 12420 matched first cancers","volume":"99","author":"Schairer","year":"2007","journal-title":"J Natl Cancer Inst"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1111\/j.1365-2141.2006.06221.x","article-title":"Chronic eosinophilic leukemia with FIP1L1-PDGFRA fusion and T6741 mutation that evolved from Langerhans cell histiocytosis with eosinophilia after chemotherapy","volume":"134","author":"Ohnishi","year":"2006","journal-title":"Br J Haematol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"113","DOI":"10.2190\/5GRE-KQ1B-UTM1-KHQ1","article-title":"A short latency between radiation exposure from nuclear plants and cancer in young children","volume":"36","author":"Mangano","year":"2006","journal-title":"Int J Health Serv"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1158\/1055-9965.EPI-06-0414","article-title":"The epidemiology of second primary cancers","volume":"15","author":"Travis","year":"2006","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1667\/RR0553.1","article-title":"The 15-Country Collaborative Study of Cancer Risk among Radiation Workers in the Nuclear Industry: estimates of radiation-related cancer risks","volume":"167","author":"Cardis","year":"2007","journal-title":"Radiation Research"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S1470-2045(02)00727-1","article-title":"Chernobyl-related ionizing radiation exposure and cancer risk: an epidemiological review","volume":"3","author":"Moysich","year":"2002","journal-title":"The Lancet Oncology"},{"key":"ref11","series-title":"20 Years after the Chernobyl accident","first-page":"331","article-title":"Twenty years after the Chernobyl accident - Is it much or not?","author":"Pelevina","year":"2006"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1038\/leu.2008.233","article-title":"Genetic complexity of myeloproliferative neoplasms","volume":"22","author":"Kralovics","year":"2008","journal-title":"Leukemia"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1056\/NEJMoa025217","article-title":"A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome","volume":"348","author":"Cools","year":"2003","journal-title":"N Engl J Med"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s002770100327","article-title":"Chronic eosinophilic leukemia with t(6;11)(q27;q23) translocation","volume":"80","author":"Suzuki","year":"2001","journal-title":"Ann Hematol"}],"container-title":["Hematology Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pagepress.org\/journals\/index.php\/hr\/article\/viewFile\/2784\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.mdpi.com\/2038-8330\/3\/2\/e17\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T06:35:20Z","timestamp":1645598120000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2038-8330\/3\/2\/e17"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,11]]},"references-count":14,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2011,8]]}},"alternative-id":["hr.2011.e17"],"URL":"https:\/\/doi.org\/10.4081\/hr.2011.e17","relation":{},"ISSN":["2038-8330"],"issn-type":[{"value":"2038-8330","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10,11]]}}}