{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T07:58:11Z","timestamp":1774684691464,"version":"3.50.1"},"reference-count":11,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2011,10,21]],"date-time":"2011-10-21T00:00:00Z","timestamp":1319155200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematology Reports"],"abstract":"<jats:p>Studies have compared the role of bone marrow aspirate cytology and trephine biopsy for diagnosing various hematological disorders but fewer studies have compared the relative value of imprint cytology with aspirate and trephine biopsy. The present study was conducted to compare the role of bone marrow aspirate, touch imprint and trephine biopsy to formulate an effective and rapid method for diagnosing wide spectrum of hematological diseases. The study included total 565 cases of bone marrow examination from January 2006 till May 2010. All the smears and sections were reviewed for morphological details and findings on aspirate, imprint and biopsy were compared to each other. The diagnostic accuracy of bone marrow aspirate was 77.5%, imprint cytology 83.7% and that of biopsy was of 99.2%. The study showed 78% positive correlation between aspirate and biopsy and 84.3% between imprint and biopsy; 93.3% cases of metastatic solid tumors were correctly diagnosed on imprint while only 70% cases were diagnosed on aspirate cytology. The study concludes that all the three preparations of aspirate, imprint and biopsy complement each other. The assessment of iron status by Perl\u2019s stain is most suitable on aspirate smears but trephine biopsy remains the gold standard for diagnosing granulomatous inflammation and hypoplastic\/ aplastic anemia. Meticulously prepared imprint smears not only provide cellular composition of marrow but may also be helpful in defining the architecture of marrow especially in cases of metastatic solid tumors. Imprint cytology smears should be standard practice for evaluating any marrow.<\/jats:p>","DOI":"10.4081\/hr.2011.e22","type":"journal-article","created":{"date-parts":[[2011,12,2]],"date-time":"2011-12-02T00:28:24Z","timestamp":1322785704000},"page":"e22","source":"Crossref","is-referenced-by-count":21,"title":["Comparison of Bone Marrow Aspirate Cytology, Touch Imprint Cytology and Trephine Biopsy for Bone Marrow Evaluation"],"prefix":"10.3390","volume":"3","author":[{"given":"Smita","family":"Chandra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harish","family":"Chandra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2011,10,21]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1179\/102453310X12647083621001","article-title":"Bone marrow metastasis by solid tumors \u2013 probable hematological indicators and comparison of bone marrow aspirate, touch imprint and trephine biopsy","volume":"15","author":"Chandra","year":"2010","journal-title":"Hematology"},{"key":"ref2","first-page":"893","article-title":"Bone marrow trephine biopsy as an adjunct to bone marrow aspiration","volume":"50","author":"Nanda","year":"2002","journal-title":"J Assoc Physicians India"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1179\/102453308X343446","article-title":"Hematological profile in pyrexia of unknown origin: role of bone marrow trephine biopsy vis-\u00e0-vis aspiration","volume":"13","author":"Gupta","year":"2008","journal-title":"Hematology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"497","DOI":"10.5858\/2005-129-497-CORVOB","article-title":"Comparison of relative valve of bone marrow aspirates and bone marrow trephine biopsies in the diagnosis of solid tumor metastasis and Hodgkin's Lymphoma - Institutional experience and literature review","volume":"129","author":"Moid","year":"2005","journal-title":"Arch Pathol Lab Med"},{"key":"ref5","first-page":"194","article-title":"Comparitive evaluation of bone marrow aspirate particle smears, imprints and biopsy sections","volume":"36","author":"Sabharwal","year":"1990","journal-title":"J Postgrad Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1002\/ajh.2830220407","article-title":"Comparative evaluation of bone marrow aspirate particle smears biopsy imprints and biopsy sections","volume":"22","author":"Donald","year":"1986","journal-title":"Am J Hematology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1093\/ajcp\/111.6.753","article-title":"Comparison of touch imprints with aspirate smears for evaluating bone marrow specimens","volume":"111","author":"Aboul-Nasr","year":"1999","journal-title":"Am J Clin Pathol"},{"key":"ref8","first-page":"945","article-title":"Comparison of touch imprints with aspirate smears for evaluating bone marrow specimens","volume":"116","author":"Barekman","year":"2001","journal-title":"Am J Clin Pathol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1002\/ajh.2830220407","article-title":"Comparitive evaluation of bone marrow aspirate particulate smears, biopsy imprints and biopsy sections","volume":"22","author":"Pasquale","year":"1986","journal-title":"Am J Haematol"},{"key":"ref10","first-page":"215","article-title":"Relative efficacy of bone marrow trephine biopsy sections as compared to trephine imprints and aspiration smears in routine hematolgocial practice","volume":"36","author":"Varma","year":"1993","journal-title":"Indian J Pathol Microbiol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s12288-010-0010-x","article-title":"Comparitive evaluation of simultaneous bone marrow aspiration and bone marrow biopsy. An institutional experience","volume":"26","author":"Ch Toi","year":"2010","journal-title":"Indian J Hematol Blood Transfus"}],"container-title":["Hematology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2038-8330\/3\/3\/e22\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T06:37:03Z","timestamp":1645598223000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2038-8330\/3\/3\/e22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,21]]},"references-count":11,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2011,10]]}},"alternative-id":["hr.2011.e22"],"URL":"https:\/\/doi.org\/10.4081\/hr.2011.e22","relation":{},"ISSN":["2038-8330"],"issn-type":[{"value":"2038-8330","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10,21]]}}}