{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T12:27:43Z","timestamp":1756384063335},"reference-count":17,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2012,2,28]],"date-time":"2012-02-28T00:00:00Z","timestamp":1330387200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematology Reports"],"abstract":"<jats:p>Hepatosplenic \u03b3\u03b4 T-cell lymphoma (HSTCL) is a very rare peripheral T-cell lymphoma characterized by extranodal infiltration of mature malignant post-thymic T-lymphocytes into sinusoids of the liver and spleen without lymphadenopathy and significant cytopenias. The aetiology of the disease is unknown. We describe the case of a female patient in whom HSTCL developed after delivery and who was previously without disease. Flow cytometry and liver puncture are essential for diagnosing HSTCL, especially in patients with unexplained pancytopenia and hepatosplenomegaly. Since phenotypic results can easily be misinterpreted as non-malignant, the examiner should have enough experience to recognize clonal changes of T-lymphocytes. Namely, in contrast to B-lymphocytes, T-lymphocytes do not have an efficient indicator of clonality and are recognized by flow cytometry based only on aberrant expression of commonly present antigens of T-cell and NK-cell subsets. At present, there is no known cure for HSTCL with a maximum survival up to 2 years.<\/jats:p>","DOI":"10.4081\/hr.2012.e4","type":"journal-article","created":{"date-parts":[[2012,2,22]],"date-time":"2012-02-22T16:47:15Z","timestamp":1329929235000},"page":"e4","source":"Crossref","is-referenced-by-count":6,"title":["Hepatosplenic Gamma-Delta T-Cell Lymphoma in a Female Patient after Delivery"],"prefix":"10.3390","volume":"4","author":[{"given":"Marjana","family":"Glaser","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ale\u0161","family":"Goropev\u0161ek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajko","family":"Kavalar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrej","family":"Glaser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2012,2,28]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"4261","DOI":"10.1182\/blood-2003-05-1675","article-title":"Hepatosplenic \u03b3\u03b4 T -cell lymphoma is a rare clinicopathologic entity with poor outcome: report on a series of 21 patients","volume":"102","author":"Belhadj","year":"2003","journal-title":"Blood"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.5858\/132.11.1774","article-title":"Immunophenotypic attributes of benign peripheral blood gammadelta T cells and conditions associated with their increase","volume":"132","author":"Roden","year":"2008","journal-title":"Arch Pathol Lab Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1309\/LRKX8CE7GVPCR1FT","article-title":"Hepatosplenic and other \u03b3\u03b4 T -cell lymphomas","volume":"127","author":"Vega","year":"2007","journal-title":"Am J Clin Pathol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1053\/hupa.2002.31301","article-title":"Hepatosplenic gamma\/delta lymphoma with leukemic course after renal transplantation","volume":"33","author":"Steurer","year":"2002","journal-title":"Hum Pathol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/nrgastro.2009.87","article-title":"Hepatosplenic T cell lymphoma in a patient with Crohn's disease","volume":"6","author":"Beigel","year":"2009","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/j.1600-0609.2004.00300.x","article-title":"Development of hepatosplenic \u03b3\u03b4 T cell lymphoma with pancitopenia during early pregnancy: a case report and review of the literature","volume":"73","author":"Niitsu","year":"2004","journal-title":"Eur J Haematol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1006\/smim.2000.0318","article-title":"The role of gamma\/delta T cells in the feto-maternal relationship","volume":"13","author":"Szekeres-Bartho","year":"2001","journal-title":"Semin Immunol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/nrclinonc.2009.169","article-title":"Gamma delta T cell lymphomas","volume":"6","author":"Tripodo","year":"2009","journal-title":"Nat Rev Clin Oncol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0037-1963(01)90045-9","article-title":"Flow cytometric analysis of lymphomas and lymphoproliferative disorders","volume":"38","author":"Stetler-Stevenson","year":"2001","journal-title":"Semin Hematol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1038\/sj.leu.2401784","article-title":"Hepatosplenic T cell lymphoma. A review on 45 cases since the first report describing the disease as a distinct lymphoma entity in 1990","volume":"14","author":"Weidmann","year":"2000","journal-title":"Leukemia"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"3729","DOI":"10.3748\/wjg.v11.i24.3729","article-title":"Hepa-tosplenic \u03b3\u03b4 T-cell lymphoma","volume":"11","author":"Wei","year":"2005","journal-title":"World J Gastroenterol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1093\/annonc\/mdn751","article-title":"Hepatosplenic gamma delta T cell lymphoma: clinicopathological features and treatment","volume":"20","author":"Falchook","year":"2009","journal-title":"Ann Oncol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1245\/s10434-009-0470-0","article-title":"Importance of early splenectomy in patients with hepatosplenic T cell lymphoma and severe thrombocytopenia","volume":"16","author":"Gumbs","year":"2009","journal-title":"Ann Surg Oncol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1093\/annonc\/mdn119","article-title":"Hepatosplenic \u03b3\u03b4 T-cell lymphoma succesfully treated with a combination of alemtuzumab and cladribine","volume":"19","author":"Jaeger","year":"2008","journal-title":"Ann Oncol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1080\/10428190310001609924","article-title":"Long term survival with allogeneic stem cell transplant and donor lymphocyte infusion following salvage therapy with anti CD 52 monoclonal antibody (Campath) in a patient with hepatosplenic \u03b1\/\u03b2 T cell non Hodgkins lymphoma","volume":"45","author":"Chanan-Khan","year":"2004","journal-title":"Leuk Lymph"},{"key":"ref16","unstructured":"Study of pralatrexate with vitamin B12 and folic acid in patients with relapsed or refractory peripheral T-cell lymphoma (PROPEL)http:\/\/clinicaltrials.gov\/ct2\/show\/NCT00364923"},{"key":"ref17","unstructured":"A Trial of Romidepsin for Progressive or Relapsed Peripheral T-cell Lymphomahttp:\/\/clinicaltrials.gov\/ct2\/show\/NCT00426764"}],"container-title":["Hematology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.pagepress.org\/journals\/index.php\/hr\/article\/download\/hr.2012.e4\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.pagepress.org\/journals\/index.php\/hr\/article\/download\/hr.2012.e4\/4969","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.mdpi.com\/2038-8330\/4\/1\/e4\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T06:42:38Z","timestamp":1645598558000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2038-8330\/4\/1\/e4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,28]]},"references-count":17,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2012,1]]}},"alternative-id":["hr.2012.e4"],"URL":"https:\/\/doi.org\/10.4081\/hr.2012.e4","relation":{},"ISSN":["2038-8330"],"issn-type":[{"value":"2038-8330","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,28]]}}}