{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T07:13:41Z","timestamp":1778656421970,"version":"3.51.4"},"reference-count":8,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2012,4,24]],"date-time":"2012-04-24T00:00:00Z","timestamp":1335225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematology Reports"],"abstract":"<jats:p>We report here a case of a woman with a cutaneous large B-cell lymphoma of the legs. She had a plaque lesion, superficially ulcerated and necrotized with tumorous borders situated on the posterior side of the right leg and two red or bluish-red nodular lesions. A skin biopsy from both nodular and plaque lesion showed a diffuse infiltrate of atypical large B cells CD20+ and CD79a+, spanning epidermis, dermis and subcutaneous tissue. A therapeutic approach containing anti-CD20 monoclonal antibody (rituximab) was suggested.<\/jats:p>","DOI":"10.4081\/hr.2012.e6","type":"journal-article","created":{"date-parts":[[2012,4,26]],"date-time":"2012-04-26T13:39:19Z","timestamp":1335447559000},"page":"e6","source":"Crossref","is-referenced-by-count":3,"title":["A Case of Cutaneous Large B-Cell Lymphoma of the Legs Appearing as Chronic Venous Ulceration"],"prefix":"10.3390","volume":"4","author":[{"given":"Marta","family":"Carlesimo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego","family":"Orsini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessanrdra","family":"Narcisi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Abruzzese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgia","family":"Cortesi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella","family":"De Marco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2012,4,24]]},"reference":[{"key":"ref1","first-page":"354","article-title":"EORTC classification for primary cutaneous lymphomas: a proposal from the cutaneous lymphoma study group of the European organization for research and treatment of cancer","volume":"90","author":"Willemze","year":"1997","journal-title":"Blood"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1182\/blood.V99.3.800","article-title":"Primary cutaneous lymphomas: applicability of current classification schemes (European Organization for Research and Treatment of Cancer, World Health Organization) based on clinicopathologic features observed in a large group of patients","volume":"99","author":"Fink-Puches","year":"2002","journal-title":"Blood"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1097\/DAD.0b013e3181877a05","article-title":"Unusual clinicopathological presentation of primary cutaneous diffuse large B-cell lymphoma, leg type, with multiple nodules and widespread garland-like lesions","volume":"31","author":"Belousova","year":"2009","journal-title":"Am J Dermatopathol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1111\/j.1365-2133.2003.05649.x","article-title":"Bcl-2, Bcl-6 and CD10 expression in cutaneous B-cell lymphoma: further support for a follicle centre cell origin and differential diagnostic significance","volume":"149","author":"Hoefnagel","year":"2003","journal-title":"Br J Dermatol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1001\/archderm.1996.03890350042008","article-title":"Primary cutaneous large B-cell lymphomas of the legs. A distinct type of cutaneous B-cell lymphoma with an intermediate prognosis. Dutch Cutaneous Lymphoma Working group","volume":"132","author":"Vermeer","year":"1996","journal-title":"Arch Dermatol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.semradonc.2007.02.002","article-title":"Diffuse large B-cell lymphoma","volume":"17","author":"Ng","year":"2007","journal-title":"Semin Radiat Oncol"},{"key":"ref7","first-page":"169","article-title":"Primary cutaneous diffuse large B-cell lymphoma, leg type, with the clinical picture of chronic venous ulceration","volume":"87","author":"Suss","year":"2007","journal-title":"Acta dermatovenereol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1586\/14737140.6.8.1175","article-title":"Rituximab for the treatment of diffuse large B-cell lymphomas","volume":"6","author":"Held","year":"2006","journal-title":"Expert Rev Anticancer Ther"}],"container-title":["Hematology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2038-8330\/4\/2\/e6\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T06:43:44Z","timestamp":1645598624000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2038-8330\/4\/2\/e6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,24]]},"references-count":8,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2012,5]]}},"alternative-id":["hr.2012.e6"],"URL":"https:\/\/doi.org\/10.4081\/hr.2012.e6","relation":{},"ISSN":["2038-8330"],"issn-type":[{"value":"2038-8330","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,24]]}}}