{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T23:27:50Z","timestamp":1649028470306},"reference-count":17,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2014,12,9]],"date-time":"2014-12-09T00:00:00Z","timestamp":1418083200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematology Reports"],"abstract":"<jats:p>Celiac disease is an autoimmune disorder in which a genetic predisposition and the ingestion of wheat gluten triggers a deleterious immune response. This response is complex and may lead to manifestations other than enteropathyha: hepatitis, dermatitis and neuropathy. There is higher risk for neoplasia. We observed an atypical case, corresponding to a 69-year old female presenting with complicated celiac disease. The patient was referred following the histological examination of an enterectomy specimen, which unexpectedly revealed an enteropathy-associated T cell lymphoma in a background of celiac disease. Patient\u2019s previous medical history comprised several abdominal surgical procedures, without other prior symptoms suggestive of celiac disease. Indeed, the patient was obese and no signs of malabsortion were apparent. This case draws our attention to clinically silent celiac disease, which represents a diagnostic challenge. Thus, this should be kept in mind whenever a patient presents with abdominal relapsing complications, otherwise unexplained.<\/jats:p>","DOI":"10.4081\/hr.2014.5612","type":"journal-article","created":{"date-parts":[[2015,1,14]],"date-time":"2015-01-14T11:33:46Z","timestamp":1421235226000},"page":"5612","source":"Crossref","is-referenced-by-count":3,"title":["Enteropathy-Associated T Cell Lymphoma as a Complication of Silent Celiac Disease"],"prefix":"10.3390","volume":"6","author":[{"given":"Margarida Dantas","family":"Brito","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c2ngelo","family":"Martins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Henrique","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Mariz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2014,12,9]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1056\/NEJMra071600","article-title":"Celiac disease","volume":"357","author":"Green","year":"2007","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"530","DOI":"10.3109\/07853890.2010.514285","article-title":"Natural history of celiac disease autoimmunity in a USA cohort followed since 1974","volume":"42","author":"Catassi","year":"2010","journal-title":"Ann Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/nm0797-797","article-title":"Identification of tissue transglutaminase as the autoantigen of celiac disease","volume":"3","author":"Dieterich","year":"1997","journal-title":"Nat Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.clim.2013.04.009","article-title":"Profiling celiac disease antibody repertoire","volume":"148","author":"D\u2019Angelo","year":"2013","journal-title":"Clin Immunol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"3879","DOI":"10.1182\/blood.V92.10.3879","article-title":"Are complicated forms of celiac disease cryptic T-cell lymphomas?","volume":"92","author":"Carbonnel","year":"1998","journal-title":"Blood"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1001\/jama.287.11.1413","article-title":"Risk of non-Hodgkin lymphoma in celiac disease (for the Italian Working Group on Coeliac Disease and Non-Hodgkin's-Lymphoma)","volume":"287","author":"Catassi","year":"2002","journal-title":"JAMA"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.gtc.2009.06.005","article-title":"Celiac disease in the elderly","volume":"38","author":"Rashtak","year":"2009","journal-title":"Gastroenterol Clin North Am"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/1471-230X-9-49","article-title":"Increasing prevalence and high incidence of celiac disease in elderly people: a population-based study","volume":"9","author":"Vilppula","year":"2009","journal-title":"BMC Gastroenterol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"6911","DOI":"10.3748\/wjg.14.6911","article-title":"Adult celiac disease in the elderly","volume":"14","author":"Freeman","year":"2008","journal-title":"World J Gastroenterol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1097\/01.mcg.0000247995.12087.7b","article-title":"Celiac disease diagnosed in the elderly","volume":"42","author":"Yoav","year":"2008","journal-title":"J Clin Gastroenterol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1093\/oxfordjournals.annonc.a058869","article-title":"Report on a workshop convened to discuss the pathological and staging classifications of gastrointestinal tract lymphoma","volume":"5","author":"Rohatiner","year":"1994","journal-title":"Ann Oncol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1007\/s10620-007-9952-8","article-title":"Effect of a gluten-free diet on the risk of enteropathy-associated T-cell lymphoma in celiac disease. Collaborating Centers of the Italian Registry of the Complications of Coeliac Disease","volume":"53","author":"Silano","year":"2008","journal-title":"Dig Dis Sci"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"169","DOI":"10.7326\/0003-4819-159-3-201308060-00006","article-title":"Mucosal healing and risk for lymphoproliferative malignancy in celiac disease: a population-based cohort study","volume":"159","author":"Lebwohl","year":"2013","journal-title":"Ann Intern Med"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1182\/blood-2011-02-335216","article-title":"Enteropathy-associated T-cell lymphoma: clinical and histological findings from the international peripheral T-cell lymphoma project","volume":"118","author":"Delabie","year":"2011","journal-title":"Blood"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1200\/JCO.2000.18.4.795","article-title":"Enteropathy-type intestinal T-cell lymphoma: clinical features and treatment of 31 patients in a single center","volume":"18","author":"Gale","year":"2000","journal-title":"J Clin Oncol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1365-2141.2006.06371.x","article-title":"Combination chemotherapy followed by autologous stem cell transplant for enteropathy-associated T cell lymphoma","volume":"136","author":"Bishton","year":"2007","journal-title":"Br J Haematol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"3664","DOI":"10.1182\/blood-2009-07-231324","article-title":"Evaluation of enteropathy-associated T-cell lymphoma comparing standard therapies with a novel regimen including autologous stem cell transplantation","volume":"115","author":"Sieniawski","year":"2010","journal-title":"Blood"}],"container-title":["Hematology Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pagepress.org\/journals\/index.php\/hr\/article\/viewFile\/5612\/4532","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.mdpi.com\/2038-8330\/6\/4\/5612\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T06:58:07Z","timestamp":1645599487000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2038-8330\/6\/4\/5612"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,9]]},"references-count":17,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2014,11]]}},"alternative-id":["hr.2014.5612"],"URL":"https:\/\/doi.org\/10.4081\/hr.2014.5612","relation":{},"ISSN":["2038-8330"],"issn-type":[{"value":"2038-8330","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,9]]}}}