{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:29:11Z","timestamp":1790666951960,"version":"4.1.0"},"reference-count":35,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2015,6,3]],"date-time":"2015-06-03T00:00:00Z","timestamp":1433289600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematology Reports"],"abstract":"<jats:p>Angioimmunoblastic T-cell lymphoma (AITL) is an aggressive peripheral T-cell lymphoma typically characterized by prominent lymphadenopathy and B-symptoms at the time of presentation, polyclonal hypergammaglobulinemia, autoimmune hemolysis and frequent but highly variable involvement of Epstein- Barr virus (EBV). Lymph node biopsy findings typically include effacement of nodal architecture, polymorphic infiltrate, atypical T-cells (usually CD4+\/CD10+\/PD1+) and prominent proliferations of high endothelial venules and follicular dendritic cells. However, this classic constellation of pathologic findings is often initially obscured by a prominence of EBV+ B-immunoblasts with or without associated peripherally circulating EBV DNA. Here we document the first reported case of an acute serologic EBV profile (VCA-IgM) in a patient with AITL, and we recommend that clinicians maintain a high index of suspicion for AITL in the appropriate clinical scenario, irrespective of Epstein-Barr related findings.<\/jats:p>","DOI":"10.4081\/hr.2015.5893","type":"journal-article","created":{"date-parts":[[2015,6,15]],"date-time":"2015-06-15T10:51:13Z","timestamp":1434365473000},"page":"5893","source":"Crossref","is-referenced-by-count":10,"title":["Angioimmunoblastic T-Cell Lymphoma Presenting with an Acute Serologic Epstein-Barr Virus Profile"],"prefix":"10.3390","volume":"7","author":[{"given":"Timothy","family":"Beer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Dorion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2015,6,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1182\/blood.V99.2.627","article-title":"Neoplastic T cells in angioimmunoblastic T-cell lymphoma express CD10","volume":"99","author":"Attygalle","year":"2002","journal-title":"Blood"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1038\/modpathol.2011.53","article-title":"CD10 and ICOS expression by multiparametric flow cytometry in angioimmunoblastic T-cell lymphoma","volume":"24","author":"Baseggio","year":"2011","journal-title":"Mod Pathol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1200\/JCO.2011.37.3647","article-title":"Clinicopathologic characteristics of angioimmunoblastic T-cell lymphoma: Analysis of the international peripheral T-cell lymphoma project","volume":"31","author":"Federico","year":"2013","journal-title":"J Clin Oncol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/bjc.1987.86","article-title":"Angio-immunoblastic lymphadenopathy: a clinical, immunological and molecular study","volume":"55","author":"Ganesan","year":"1987","journal-title":"Br J Cancer"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1097\/MD.0b013e3181573059","article-title":"Angioimmunoblastic T-cell lymphoma: clinical and laboratory features at diagnosis in 77 patients","volume":"86","author":"Lachenal","year":"2007","journal-title":"Medicine (Baltimore)"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/ijc.10758","article-title":"Angioimmunoblastic T cell lymphoma is derived from mature T-helper cells with varying expression and loss of detectable CD4","volume":"103","author":"Lee","year":"2003","journal-title":"Int J Cancer"},{"key":"ref7","first-page":"6097","article-title":"Angioimmunoblastic T-cell lymphoma in taiwan shows a frequent gain of ITK gene","volume":"7","author":"Liang","year":"2014","journal-title":"Int J Clin Exp Pathol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.3109\/10428194.2010.525270","article-title":"Clinical features and prognostic factors of angioimmunoblastic T-cell lymphoma in Taiwan: a single-institution experience","volume":"51","author":"Lin","year":"2010","journal-title":"Leuk Lymphoma"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"4463","DOI":"10.1182\/blood-2007-08-105759","article-title":"Clinical, biologic, and pathologic features in 157 patients with angioimmunoblastic T-cell lymphoma treated within the groupe d\u2019etude des lymphomes de l\u2019adulte (GELA) trials","volume":"111","author":"Mourad","year":"2008","journal-title":"Blood"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1002\/cncr.2820690531","article-title":"Clinicopathologic and therapeutic aspects of angioimmunoblastic lymphadenopathy-related lesions","volume":"69","author":"Ohsaka","year":"1992","journal-title":"Cancer"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1080\/10428190601123989","article-title":"Clinical features and treatment outcomes of angioimmunoblastic T-cell lymphoma","volume":"48","author":"Park","year":"2007","journal-title":"Leuk Lymphoma"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"545","DOI":"10.3109\/10428199909058412","article-title":"Angioimmunoblastic-like T-cell non hodgkin\u2019s lymphoma: outcome after chemotherapy in 33 patients and review of the literature","volume":"32","author":"Pautier","year":"1999","journal-title":"Leuk Lymphoma"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1093\/oxfordjournals.annonc.a059281","article-title":"Angioimmunoblastic lymphadenopathy (AILD)-type T-cell lymphoma: prognostic impact of clinical observations and laboratory findings at presentation. 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A case report and immunologic study","volume":"24","author":"Kanzaki","year":"1997","journal-title":"Auris Nasus Larynx"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"e64","DOI":"10.1200\/JCO.2012.43.8226","article-title":"Primary cerebral angioimmunoblastic T-cell lymphoma","volume":"31","author":"Lachenal","year":"2013","journal-title":"J Clin Oncol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1007\/s12185-013-1411-z","article-title":"Clinical manifestation of angioimmunoblastic T-cell lymphoma with exuberant plasmacytosis","volume":"98","author":"Nagoshi","year":"2013","journal-title":"Int J Hematol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1007\/s10157-010-0266-3","article-title":"Angioimmunoblastic T-cell lymphoma and membranous nephropathy: a still unreported association","volume":"14","author":"Togashi","year":"2010","journal-title":"Clin Exp Nephrol"}],"container-title":["Hematology Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pagepress.org\/journals\/index.php\/hr\/article\/viewFile\/5893\/4670","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.mdpi.com\/2038-8330\/7\/2\/5893\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T05:46:30Z","timestamp":1652420790000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2038-8330\/7\/2\/5893"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,3]]},"references-count":35,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015,6]]}},"alternative-id":["hr.2015.5893"],"URL":"https:\/\/doi.org\/10.4081\/hr.2015.5893","relation":{},"ISSN":["2038-8330"],"issn-type":[{"value":"2038-8330","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,3]]}}}