{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T12:13:03Z","timestamp":1764936783206},"reference-count":20,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2015,9,23]],"date-time":"2015-09-23T00:00:00Z","timestamp":1442966400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematology Reports"],"abstract":"<jats:p>Paroxysmal nocturnal hemoglobinuria (PNH) is an ultra-orphan disease affecting all hematopoietic cell types. The abnormality of red blood cells in this disease predisposes to intravascular complement-mediated hemolysis. Eculizumab is an orphan drug used to treat this rare disease. Thrombosis is the key cause of death in PNH patients in about 40% to 67% of cases. We report the case of a woman presenting with PNH complicated with serious Budd-Chiari syndrome thrombosis and with a stent inserted in the portal vein. She refused to take any anticoagulant treatment since she commenced eculizumab 4 years before. No thrombotic events happened since that time. This case could add an extra benefit for eculizumab, which could be used as an anti-thromboembolic prophylactic agent in PNH, especially in patients with thrombocytopenia, where the use of anticoagulant agents is extremely hazardous. More randomized studies might establish the use of eculizumab without anticoagulants to avoid serious bleeding that could happen in thrombocytopenic PNH patients.<\/jats:p>","DOI":"10.4081\/hr.2015.5927","type":"journal-article","created":{"date-parts":[[2015,9,23]],"date-time":"2015-09-23T08:06:53Z","timestamp":1442995613000},"page":"5927","source":"Crossref","is-referenced-by-count":7,"title":["Long Standing Eculizumab Treatment without Anticoagulant Therapy in High-Risk Thrombogenic Paroxysmal Nocturnal Hemoglobinuria"],"prefix":"10.3390","volume":"7","author":[{"given":"Hassan A.","family":"Al-Jafar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salma M.","family":"AlDallal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haifa A.","family":"Askar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali M.","family":"Aljeraiwi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad","family":"Al-Alansari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2015,9,23]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3324\/haematol.2008.001297","article-title":"Paroxysmal nocturnal hemoglobinuria and meyelodysplastic syndromes: clonal expansion of PIG-A-mutant hematopoietic cells in bone marrow failure","volume":"94","author":"Young","year":"2009","journal-title":"Haematologica"},{"key":"ref2","article-title":"NICE Citizens Council Report Ultra Orphan Drugs","year":"2004"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"3699","DOI":"10.1182\/blood-2005-04-1717","article-title":"Diagnosis and management of paroxysmal nocturnal hemoglobinuria","volume":"106","author":"Parker","year":"2005","journal-title":"Blood"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"5047","DOI":"10.1093\/emboj\/cdf508","article-title":"Requirement of N-glycan on GPI-anchored proteins for efficient binding of aerolysin but not Clostridium septicum \u03b1-toxin","volume":"21","author":"Hong","year":"2002","journal-title":"EMBO J"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1182\/blood-2007-04-083170","article-title":"Factor H-mediated cell surface protection from complement is critical for the survival of PNH erythrocytes","volume":"110","author":"Ferreira","year":"2007","journal-title":"Blood"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"6522","DOI":"10.1182\/blood-2009-03-195966","article-title":"How I treat paroxysmal nocturnal hemoglobinuria","volume":"113","author":"Brodsky","year":"2009","journal-title":"Blood"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"587","DOI":"10.7326\/0003-4819-148-8-200804150-00003","article-title":"Paroxysmal nocturnal hemoglobinuria: thephysiology of complement-related hemolytic anemia","volume":"148","author":"Brodsky","year":"2008","journal-title":"Ann Intern Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"4985","DOI":"10.1182\/blood-2012-09-311381","article-title":"Thrombosis in paroxysmal nocturnal hemoglobinuria","volume":"121","author":"Hill","year":"2013","journal-title":"Blood"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1111\/j.1538-7836.2007.02379.x","article-title":"Thrombosis in paroxysmal nocturnal hemoglobinuria: sites, risks, outcome. 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