{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T19:28:42Z","timestamp":1750102122958},"reference-count":15,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T00:00:00Z","timestamp":1550534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematology Reports"],"abstract":"<jats:p>Within T-cell lymphomas (TCL) there are 2 entities expressing gamma-delta TCR: hepatosplenic gamma-delta T-cell lymphoma (HSGDTL) and the primary cutaneous gamma-delta T-cell lymphoma (PCGDTL). PCGDTL is a rare form of T-cell lymphoma with specific tropism for skin that have a dismal prognosis. Although even rarer, there have been reports of TCL with loss of expression of the TCR, which have been termed peripheral TCL TCR-silent type. We report the case of a cutaneous TCR-silent type lymphoma associated to a clonal plasma cell proliferation with an ominous outcome that led to a lot of discussion in its classification. Due to the aggressiveness of the disease and the scant evidence about therapy in this strange entity the outcome was fatal. We report a unique case of a TCR-silent cutaneous TCL with an exceptional histopathology, prolonged clinical evolution and a subsequent plasma cell clonal expansion.<\/jats:p>","DOI":"10.4081\/hr.2019.7841","type":"journal-article","created":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T08:33:18Z","timestamp":1550565198000},"page":"7841","source":"Crossref","is-referenced-by-count":4,"title":["Silent T-Cell Receptor Cutaneous T-Cell Lymphoma Associated to a Clonal Plasma Cell Proliferation"],"prefix":"10.3390","volume":"11","author":[{"given":"Ana","family":"Caballero","sequence":"first","affiliation":[{"name":"Department of Hematology, Hospital de la Santa Creu i Sant Pau, Carrer Mas Casanovas, 90 4th Floor, 08041 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvana","family":"Novelli","sequence":"additional","affiliation":[{"name":"Department of Hematology, Hospital de la Santa Creu i Sant Pau, Carrer Mas Casanovas, 90 4th Floor, 08041 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Mozos","sequence":"additional","affiliation":[{"name":"Pathology Department, Hospital de la Santa Creu i Sant Pau, 08041 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pilar","family":"Garcia Muret","sequence":"additional","affiliation":[{"name":"Dermatology Department, Hospital de la Santa Creu i Sant Pau, 08041 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Sierra","sequence":"additional","affiliation":[{"name":"Department of Hematology, Hospital de la Santa Creu i Sant Pau, Carrer Mas Casanovas, 90 4th Floor, 08041 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Briones","sequence":"additional","affiliation":[{"name":"Department of Hematology, Hospital de la Santa Creu i Sant Pau, Carrer Mas Casanovas, 90 4th Floor, 08041 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,2,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1182\/blood-2016-01-643569","article-title":"The 2016 revision of the World Health Organization classification of lymphoid neoplasms","volume":"127","author":"Swerdlow","year":"2016","journal-title":"Blood"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/ejh.12439","article-title":"Gamma-delta tcell lymphomas","volume":"94","author":"Foppoli","year":"2015","journal-title":"Eur J Haematol"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e195","DOI":"10.1016\/j.clml.2014.06.024","article-title":"T-cell receptor-\u03b3 in gamma-delta phenotype cutaneous T-cell lymphoma can be accompanied by atypical expression of CD30, CD4, or TCR\u03b2F1 and an indolent clinical course","volume":"14","author":"Vin","year":"2014","journal-title":"Clin Lymphoma Myeloma Leuk"},{"key":"ref_4","first-page":"617","article-title":"Expression of the alpha\/beta and gamma\/delta T-cell receptors in 57 cases of peripheral T-cell lymphomas. 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