{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T20:51:57Z","timestamp":1761598317509},"reference-count":9,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T00:00:00Z","timestamp":1615507200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematology Reports"],"abstract":"<jats:p>Hemorrhagic cystitis (HC) secondary to BK polyomavirus (BKPyV) is a frequent complication related to allogenic stem cell transplantation. With an important morbidity and mortality, this disease doesn\u2019t have a stablished standard treatment or prophylaxis strategies. At this moment, the supportive therapies approved to treat included hyperhydration, forced diuresis and transfusion support. Cidofovir is a nucleotide analog of deoxycytidine monophosphate against DNA viruses and it has been described for the treatment of BKPyV-HC, but at this moment, is not a front-line therapy. We report a successful case after the use of Cidofovir without Probenecid. No adverse effect was developed under the treatment, and after 4 weeks of treatment, the patient achieved an excellent response.<\/jats:p>","DOI":"10.4081\/hr.2021.8574","type":"journal-article","created":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T08:50:25Z","timestamp":1615539025000},"page":"8574","source":"Crossref","is-referenced-by-count":2,"title":["Hemorrhagic Cystitis: A Successful Outcome for a Challenging Complication in Stem Cell Transplant"],"prefix":"10.3390","volume":"13","author":[{"given":"Sergio","family":"Pinz\u00f3n Mari\u00f1o","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samira","family":"Bakali Badesa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Jes\u00fas","family":"Viso Soriano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Izquierdo Garcia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,12]]},"reference":[{"key":"ref1","first-page":"1561","article-title":"Role of cidofovir in the treatment of DNA virus infections, other than CMV infections, in immunocompromised patients","volume":"3","author":"Snoeck","year":"2002","journal-title":"Curr Opin Investig Drugs"},{"key":"ref2","first-page":"12","article-title":"ECIL guidelines for the prevention, diagnosis and treatment of BK polyomavirus-associated haemorrhagic cystitis in haematopoietic stem cell transplant recipients","volume":"73","author":"Cesaro","year":"2018","journal-title":"J Antimicrob Chemother"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.3324\/haematol.2009.016758","article-title":"Hemorrhagic cystitis after allogeneic hematopoietic stem cell transplants is the complex result of BK virus infection, preparative regimen intensity and donor type","volume":"95","author":"Silva","year":"2010","journal-title":"Haematologica"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1038\/bmt.2015.162","article-title":"Hemorrhagic cystitis after allogeneic hematopoietic cell transplantation: risk factors, graft source and survival","volume":"50","author":"Lunde","year":"2015","journal-title":"Bone Marrow Transplant"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1761-3310(19)41719-2","article-title":"Cistitis hemorr\u00e1gica: fisiopatolog\u00eda y conducta pr\u00e1ctica","volume":"51","author":"Colombel","year":"2019","journal-title":"EMC - Urolog\u00eda"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.bbmt.2014.04.017","article-title":"Relationship of BK polyoma virus (BKV) in the urine with hemorrhagic cystitis and renal function in recipients of T Cell-depleted peripheral blood and cord blood stem cell transplantations","volume":"20","author":"Lee","year":"2014","journal-title":"Biol Blood Marrow Transplant"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ijsu.2019.01.019","article-title":"BK Virus Associated Haemorrhagic Cystitis. A systematic review of current prevention and treatment strategies","volume":"63","author":"Aldiwani","year":"2019","journal-title":"Int J Surg"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1016\/j.bbmt.2018.04.009","article-title":"Efficacy of Cidofovir in Treatment of BK Virus-Induced Hemorrhagic Cystitis in Allogeneic Hematopoietic Cell Transplant Recipients","volume":"24","author":"Coomes","year":"2018","journal-title":"Biol Blood Marrow Transplant"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1177\/1060028019897896","article-title":"Intravesicular Cidofovir in the Treatment of BK Virus-Associated Hemorrhagic Cystitis Following Hematopoietic Stem Cell Transplantation","volume":"54","author":"Tooker","year":"2020","journal-title":"Ann Pharmacother"}],"container-title":["Hematology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.pagepress.org\/journals\/index.php\/hr\/article\/download\/8574\/8538","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.mdpi.com\/2038-8330\/13\/1\/8574\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T07:34:47Z","timestamp":1645601687000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2038-8330\/13\/1\/8574"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,12]]},"references-count":9,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,3]]}},"alternative-id":["hr.2021.8574"],"URL":"https:\/\/doi.org\/10.4081\/hr.2021.8574","relation":{},"ISSN":["2038-8330"],"issn-type":[{"value":"2038-8330","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,12]]}}}