{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T08:24:59Z","timestamp":1769847899824,"version":"3.49.0"},"reference-count":35,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2012,2,22]],"date-time":"2012-02-22T00:00:00Z","timestamp":1329868800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infectious Disease Reports"],"abstract":"<jats:p>Various countries have implemented anti-rubella vaccination campaigns with the main aim of preventing congenital infection. In 2003, Italy joined the European WHO programme for the elimination of congenital rubella and issued a special healthcare plan, one of the objectives of which was to reduce the proportion of rubella-susceptible pregnant women to less than 5% by 2005. The aim of this study was to determine the percentage of seronegative pregnant women after the implementation of this plan. Anti-rubella IgG and IgM antibodies were sought in 2385 pregnant women who attended our hospital for serological screening between 1 July 2008 and 30 June 2010. They included 750 women of foreign origin (31.4%). Eight percent of the women were anti-rubella seronegative: 6.2% of the Italians and 11.7% of the non-Italians. Among the women of foreign origin, the percentage of seronegativity ranged from 5.6% of those coming from Eastern Europe to 17.7% of those coming from Latin America. The level of seropositivity among women of Italian origin is high, although the objective of ensuring less than 5% of susceptible pregnant women has not yet been quite reached in our area. However, particular attention needs to be given to women coming from geographical areas characterised by different epidemiologies and vaccination strategies because the percentage of seronegativity is in some cases double that of Italian women.<\/jats:p>","DOI":"10.4081\/idr.2012.e17","type":"journal-article","created":{"date-parts":[[2012,2,22]],"date-time":"2012-02-22T16:54:08Z","timestamp":1329929648000},"page":"e17","source":"Crossref","is-referenced-by-count":14,"title":["Rubella Antibody Screening during Pregnancy in an Urban Area of Northern Italy"],"prefix":"10.3390","volume":"4","author":[{"given":"Massimo","family":"De Paschale","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Teresa","family":"Manco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessia","family":"Paganini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Agrappi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Mirri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella","family":"Cucchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Saccani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Flores D\u2019Arcais","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierangelo","family":"Clerici","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2012,2,22]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1097\/00006454-199507000-00004","article-title":"High incidence of congenital rubella syndrome after a rubella outbreak","volume":"14","author":"Mellinger","year":"1995","journal-title":"Pediatr Infect Dis J"},{"key":"ref2","series-title":"Infectious diseases of the fetus and newborn infant","first-page":"893","author":"Cooper","year":"2006"},{"key":"ref3","unstructured":"Report of a meeting on preventing congenital rubella syndrome: immunization strategies, surveillance needs, Geneva, 12\u201314 January 2000https:\/\/extranet.who.int\/ivb_docs\/documents\/1928"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1017\/S002217240002893X","article-title":"Vaccination against rubella and measles: quantitative investigations of different policies","volume":"90","author":"Anderson","year":"1983","journal-title":"J Hyg"},{"key":"ref5","first-page":"301","article-title":"Rubella vaccines: WHO position paper","volume":"86","year":"2011","journal-title":"Wkly Epidemiol Rec"},{"key":"ref6","first-page":"49","article-title":"European Health for All Series. Health21: The health for all policy framework for the WHO European Region","volume":"6","year":"1999"},{"key":"ref7","article-title":"Eliminating measles and rubella and preventing congenital rubella infection. WHO European Region strategic plan 2005-2010","year":"2005"},{"key":"ref8","first-page":"843","article-title":"Infant immunization coverage in Italy: estimates by simultaneous EPI cluster surveys of regions","volume":"77","author":"Salmaso","year":"1999","journal-title":"Bull World Health Organ"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"4351","DOI":"10.1016\/j.vaccine.2004.04.026","article-title":"Do changes in policy affect vaccine coverage levels? Results of a national study to evaluate childhood vaccination coverage and reasons for missed vaccination in Italy","volume":"22","author":"Ciofi degli Atti","year":"2004","journal-title":"Vaccine"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1017\/S0950268802007677","article-title":"Epidemiology of measles, mumps and rubella in Italy","volume":"129","author":"Gabutti","year":"2002","journal-title":"Epidemiol Infect"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1017\/S0950268806007400","article-title":"Rubella seroprofile of the Italian population: an 8-year comparison","volume":"135","author":"Rota","year":"2007","journal-title":"Epidemiol Infect"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1017\/S0950268899004574","article-title":"The seroepidemilogy of rubella in Western Europe","volume":"125","author":"Pebody","year":"2000","journal-title":"Epidemiol Infect"},{"key":"ref13","first-page":"33","article-title":"A novel and rapid method for determination of rubella virus immunoglobulin G avidity","volume":"11","author":"Eggers","year":"2005","journal-title":"Clin Microbiol Infect"},{"key":"ref14","first-page":"93","article-title":"Rubella epidemiology in Italy in the years 1998-2004","volume":"19","author":"Giambi","year":"2007","journal-title":"Ann Ig"},{"key":"ref15","first-page":"236","article-title":"Eliminating congenital rubella: a seroepidemiological study on women of childbearing age and MMR vaccine coverage in newborns","volume":"50","author":"Lo Giudice","year":"2009","journal-title":"J Prev Med Hyg"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"7142","DOI":"10.1016\/j.vaccine.2006.06.062","article-title":"Levels of rubella antibody among vaccinated and unvaccinated Portuguese mothers and their newborns","volume":"24","author":"Gon\u00e7alves","year":"2006","journal-title":"Vaccine"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1093\/eurpub\/ckm034","article-title":"Rubella immune status of indigenous and immigrant pregnant women in Catalonia, Spain","volume":"17","author":"Dominguez","year":"2007","journal-title":"Europ J Public Health"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.vaccine.2009.10.130","article-title":"Serum levels of rubella-specific antibodies in Swedish women following three decades of vaccination programmes","volume":"28","author":"Kakoulidou","year":"2010","journal-title":"Vaccine"},{"key":"ref19","first-page":"3106","article-title":"Duration of rubella immunity induced by two-dose measles, mumps and rubella (MMR) vaccination","volume":"18","author":"Davidkin","year":"2000","journal-title":"A 15-year follow-up in Finland. Vaccine"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2594","DOI":"10.1016\/j.vaccine.2005.12.015","article-title":"Waning antibodies in measles and rubella vaccinees-a longitudinal study","volume":"24","author":"Kremer","year":"2006","journal-title":"Vaccine"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/S0140-6736(88)92512-3","article-title":"Rubella vaccination: persistence of antibodies for 10-21 years","volume":"2","author":"O'Shea","year":"1988","journal-title":"Lancet"},{"key":"ref22","first-page":"558","article-title":"Measles, mumps, and rubella antibodies in vaccinated Baltimore children","volume":"147","author":"King","year":"1993","journal-title":"Am J Dis Child"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0264-410X(94)90009-4","article-title":"Long-term follow-up study of rubella antibodies in naturally immune and vaccinated young adults","volume":"12","author":"Christenson","year":"1994","journal-title":"Vaccine"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1086\/528993","article-title":"Persistence of measles, mumps, and rubella antibodies in an MMR-vaccinated cohort: a 20-year follow-up","volume":"197","author":"Davidkin","year":"2008","journal-title":"J Infect Dis"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1093\/ajcp\/106.2.170","article-title":"Rubella immunity: defining the level of protective antibody","volume":"106","author":"Skendzel","year":"1996","journal-title":"Am J Clin Pathol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1086\/513967","article-title":"Serum levels of rubella virus antibodies indicating immunity: response to vaccination of subjects with low or undertectable antibody concentrations","volume":"175","author":"Matter","year":"1997","journal-title":"J Infect Dis"},{"key":"ref27","unstructured":"Strategic plan for measles and congenital rubella infection in the European Region of WHOhttp:\/\/www.euro.who.int\/en\/what-we-do\/health-topics\/communicable-diseases\/measles-and-rubella\/publications\/pre-2009\/strategic-plan-for-measles-and-congenital-rubella-infection-in-the-european-region-of-who"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1111\/j.1471-0528.1987.tb02355.x","article-title":"Immunity to rubella among women of child-bearing age","volume":"94","author":"Lever","year":"1987","journal-title":"Br J Obstet Gynaecol"},{"key":"ref29","article-title":"Immigrazione. Dossier Statistico 2008. XVIII Rap-porto","year":"2008"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.jcv.2003.11.006","article-title":"Evaluation of rubella IgM enzyme immunoassays","volume":"30","author":"Tipples","year":"2004","journal-title":"J Clin Virol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"S86","DOI":"10.1093\/clinids\/7.Supplement_1.S86","article-title":"Persistence of rubella antibodies after vaccination: detection after experimental challenge","volume":"7","author":"Banatvala","year":"1985","journal-title":"Rev Infect Dis"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1136\/bmj.299.6702.773","article-title":"Fetal infection after maternal reinfection with rubella: criteria for defining reinfection","volume":"299","author":"Best","year":"1989","journal-title":"BMJ"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1007\/BF00917569","article-title":"Recent rubella virus infection indicated by a low avidity of specific IgG","volume":"8","author":"Hedman","year":"1988","journal-title":"J Clin Immunol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1007\/BF01639523","article-title":"Rubella IgG total antibody avidity and IgG subclass-specific antibody avidity assay and their role in the differentiation between primary rubella and rubella reinfection","volume":"17","author":"Enders","year":"1989","journal-title":"Infection"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0928-0197(97)00018-4","article-title":"Maturation of rubella IgG avidity over time after acute rubella infection","volume":"8","author":"B\u00f6ttiger","year":"1997","journal-title":"Clin Diagn Virol"}],"container-title":["Infectious Disease Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pagepress.org\/journals\/index.php\/idr\/article\/viewFile\/3533\/3440","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.pagepress.org\/journals\/index.php\/idr\/article\/viewFile\/3533\/5119","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.mdpi.com\/2036-7449\/4\/1\/e17\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T03:11:47Z","timestamp":1644462707000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2036-7449\/4\/1\/e17"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,22]]},"references-count":35,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2012,1]]}},"alternative-id":["idr.2012.e17"],"URL":"https:\/\/doi.org\/10.4081\/idr.2012.e17","relation":{},"ISSN":["2036-7449"],"issn-type":[{"value":"2036-7449","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,22]]}}}