{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T22:28:26Z","timestamp":1780093706919,"version":"3.54.0"},"reference-count":19,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2012,9,18]],"date-time":"2012-09-18T00:00:00Z","timestamp":1347926400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infectious Disease Reports"],"abstract":"<jats:p>Infections caused by Pseudomonas aeruginosa are becoming more common and increasingly more difficult to treat due to the continued development of drug resistance. While sensitivity to colistin (polymyxin E) is well known, it is frequently avoided due to concerns of nephrotoxicity. Reported here is a case of a multi-drug resistance pseudomonal typhlitis, bacteremia and pleural cavity infection that required significant intensive care, and serial abdominal washouts. Intra-peritoneal tobramycin in combination with broad-spectrum intravenous antibiotics including colistin were used. Several instillations of tobramycin into the abdominal cavity along with concomitant IV administration of colistin, ceftazidime and tobramycin and per os colistin, tobramycin and nystatin resulted in the clearance of the pseudomonal infection without any evidence of toxicity from the treatment. Intra-abdominal tobramycin with parenteral colistin therapy can be used in complicated clinical settings with appropriate nephroprotection.<\/jats:p>","DOI":"10.4081\/idr.2012.e36","type":"journal-article","created":{"date-parts":[[2012,9,18]],"date-time":"2012-09-18T14:54:45Z","timestamp":1347980085000},"page":"e36","source":"Crossref","is-referenced-by-count":2,"title":["An Usual Approach to Treatment of a Case of Multidrug Resistance Pseudomonas aeruginosa Peritonitis: Parenteral and Intraperitoneal Aminoglycosides and Parenteral Colistin"],"prefix":"10.3390","volume":"4","author":[{"given":"Ian","family":"May","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maha","family":"Abu-Khdeir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland Alexander","family":"Blackwood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2012,9,18]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1086\/338782","article-title":"multiple mechanisms of antimicrobial resistance in Pseudomonas aeruginosa: our worst nightmare?","volume":"34","author":"Livermore","year":"2002","journal-title":"Clin Infect Dis"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3389\/fmicb.2011.00065","article-title":"Pseudomonas aeruginosa: resistance to the max","volume":"2","author":"Poole","year":"2011","journal-title":"Front Microbiol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"612","DOI":"10.3346\/jkms.2011.26.5.612","article-title":"Pseudomonas aeruginosa bacteremia in children over ten consecutive years: analysis of clinical characteristics, risk factors of multi-drug resistance and 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patients","volume":"2","author":"Michalopoulos","year":"2011","journal-title":"Ann Intensive Care"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"230","DOI":"10.4103\/0255-0857.83905","article-title":"Polymyxins: antimicrobial susceptibility concerns and therapeutic options","volume":"29","author":"Balaji","year":"2011","journal-title":"Indian J Med Microbiol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1345\/aph.18426","article-title":"Polymyxin B sulfate and colistin: old antibiotics for emerging multiresistant gram-negative bacteria","volume":"33","author":"Evans","year":"1999","journal-title":"Ann Pharmacother"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1086\/514732","article-title":"Intravenous colistin as therapy for nosocomial infections caused by multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii","volume":"28","author":"Levin","year":"1999","journal-title":"Clin Infect 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Med"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"3523","DOI":"10.1128\/JCM.38.9.3523-3523.2000","article-title":"Intrathecal use of colistin","volume":"38","author":"Vasen","year":"2000","journal-title":"J Clin Microbiol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1345\/aph.1E485","article-title":"Intrathecal colistin and sterilization of resistant Pseudomonas aeruginosa shunt infection","volume":"39","author":"Quinn","year":"2005","journal-title":"Ann Pharmacother"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1093\/jac\/19.6.831","article-title":"Colistin inhalation therapy in cystic fibrosis patients with chronic Pseudomonas aeruginosa lung infection","volume":"19","author":"Jensen","year":"1987","journal-title":"J Antimicrob Chemother"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1164\/ajrccm.162.1.9910071","article-title":"Treatment of nosocomial pneumonia and tracheobronchitis caused by multidrug-resistant Pseudomonas aeruginosa with aerosolized colistin","volume":"162","author":"Hamer","year":"2000","journal-title":"Am J Respir Crit Care Med"}],"container-title":["Infectious Disease 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