{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T05:43:47Z","timestamp":1787895827214,"version":"build-2784847793"},"reference-count":34,"publisher":"AOSIS","issue":"9","license":[{"start":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T00:00:00Z","timestamp":1696032000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Public Health Afr."],"abstract":"<jats:p>Conducting research during disease outbreaks can be ethically challenging as evidenced in the 2014\u20112016 Ebola outbreak in West Africa and COVID\u201119 pandemic. Yet, there has been little empirical research conducted for understanding the views and perspectives of different stakeholders regarding ethical issues in conducting research during disease outbreaks. This preliminary study was conducted to empirically explore African public health research stakeholders' views about research ethics issues during infectious disease outbreaks in Africa. We conducted an online survey of 330 participants attending the International Conference on Re\u2011emerging and Emerging Infectious Disease (ICREID) meeting that took place from 13\u201115 March 2019 in Addis Ababa, Ethiopia to elicit their views on various research ethics complexities experienced in the 2014 Ebola outbreak. Study results revealed some divergent views on several ethical themes including: ethics of using unregistered interventions in outbreaks; acceptable study design; ethics review processes; risks\u2011benefit assessment; exclusion of pregnant women and children; and biological sample and data sharing. Majority (76.3%) of respondents felt that in the absence of available standard treatments or prevention modalities, the use of investigational interventions can be ethically justifiable if there is a strong scientific rationale and favorable risk\u2011benefit ratio. Regarding conventional placebo\u2011controlled trials during outbreaks with high case fatality rates, respondents that considered this unethical were more than three times those that felt such design were ethically justifiable. We were somewhat surprised that a majority (almost 60%) of respondents were satisfied with the exclusion of pregnant women and children in clinical trials during outbreaks. All respondents concurred with the prioritization of informed consent for research during an outbreak. Based on our findings, research ethics guidance is needed to equip research stakeholders in dealing with ethical complexities arising in the conduct of research during emerging disease outbreaks\u2011especially regarding using experimental interventions; placebo trial design; inclusion or justified exclusion of pregnant women and children; and biological sample\/data sharing. The findings will be used in ongoing efforts of developing a consultative and coherent African\u2011centric framework to support ethical conduct of research for future emerging infectious disease outbreaks in Africa.<\/jats:p>","DOI":"10.4081\/jphia.2023.1632","type":"journal-article","created":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T09:22:51Z","timestamp":1695892971000},"page":"6","source":"Crossref","is-referenced-by-count":6,"title":["Research ethics during infectious disease outbreaks: A survey of African research stakeholders using the Ebola virus disease outbreak as a case"],"prefix":"10.4102","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9849-5088","authenticated-orcid":false,"given":"Raji","family":"Tajudeen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3324-1607","authenticated-orcid":false,"given":"Blessing","family":"Silaigwana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexei","family":"Yavlinsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah J.L.","family":"Edwards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2580","published-online":{"date-parts":[[2023,9,30]]},"reference":[{"key":"22074","doi-asserted-by":"crossref","unstructured":"Heymann DL, Chen L, Takemi K, et al. 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