{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T09:57:55Z","timestamp":1766138275292,"version":"3.30.1"},"reference-count":25,"publisher":"AOSIS","issue":"1","license":[{"start":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T00:00:00Z","timestamp":1680134400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Public Health Afr."],"abstract":"<jats:p>ackground: p-methoxycinnamic acid (pMCA) is an ethyl p-methoxycinnamic derivative, which is the largest active ingredient in the rhizome of the kencur (Kaempferia galanga L) plant. Several studies reported that the compound has anti-inflammatory activity but has low solubility in water. The formation of a pMCA-\u03b2-cyclodextrin (\u03b2CD) inclusion complex with a molar ratio of 1:1 can increase its solubility. The formation of inclusion complexes with conventional methods requires a long time and the yield value is not optimal. Objective: This study aims to evaluate the dissolution of the pMCA-\u03b2CD inclusion complex produced using the microwave irradiation method. Methods: The product was manufactured with chloroform solvent and a power of 400 watts (power 80%). It was then evaluated using the Differential Thermal Analysis (DTA) every 2 minutes until the 8th minute. The reaction was complete after 4 minutes of treatment with a yield of 96.5%. The obtained inclusion complexes were evaluated using DTA, FTIR, and PXRD. Subsequently, a dissolution test was carried out using a type 2 apparatus in distilled water medium of pH 6.8\u00b10.05 at 37\u00b10.5\u00b0C. Results: The results showed that there was a change in the melting temperature profile, infrared spectra, and crystallinity of the product. An 89.18% dissolution was also obtained within 60 minutes, which was twice that of pMCA compounds. Conclusion: From the results of the study, it can be concluded that the formation of pMCA-\u03b2CD inclusion complexes using the microwave irradiation method is capable of providing high-yield values in a short time.<\/jats:p>","DOI":"10.4081\/jphia.2023.2500","type":"journal-article","created":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T14:59:57Z","timestamp":1678978797000},"page":"7","source":"Crossref","is-referenced-by-count":2,"title":["The dissolution of p-methoxycinnamic acid-\u03b2-cyclodextrin inclusion complex produced with microwave irradiation"],"prefix":"10.4102","volume":"14","author":[{"given":"Dewi","family":"Isadiartuti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juni","family":"Ekowati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noorma","family":"Rosita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nabella R.","family":"Amalia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2580","published-online":{"date-parts":[[2023,3,30]]},"reference":[{"key":"11502","unstructured":"Sharma P. Cinnamic acid derivatives: A new chapter of various pharmacological activities. J Chem Pharm Res. 2011;3:403\u201323."},{"key":"11503","unstructured":"Ekowati J, Diyah NW. Antinociceptive activity and in silico test against cyclooxygenase from p-methoxycinnamic acid and m-methoxycinnamic acid. BIKF. 2013;2:33\u201340."},{"key":"11504","doi-asserted-by":"crossref","unstructured":"Guzman JD. Natural cinnamic acids, synthetic derivatives and hybrids with antimicrobial activity. Molecules, 2014;19:19292\u2013349.","DOI":"10.3390\/molecules191219292"},{"key":"11505","unstructured":"Isadiartuti D, Rosita N, Syahrani A, et al. pH Adjustment and Inclusion Complex Formation With Hydroxypropyl-\u03b2-Cyclodextrin To Increase p-Methoxycinnamic Acid Solubility. J Chem Technol Metall. 2022;57:723-9."},{"key":"11506","doi-asserted-by":"crossref","unstructured":"Cheirsilp B, Rakmai J. Inclusion complex formation of cyclodextrin with its guest and their applications. 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