{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:10:49Z","timestamp":1792156249816,"version":"4.4.0"},"reference-count":47,"publisher":"AOSIS","issue":"1","license":[{"start":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T00:00:00Z","timestamp":1680134400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Public Health Afr."],"abstract":"<jats:p>Background: Virus infections are presently seen as a major public health problem. Hepatitis C Virus (HCV) is recognized as a \u201csilent killer\u201d because the acute infection has no symptoms, and it develops as a chronic infection that causes hepatocellular carcinoma and liver damage. The World Health Organization (WHO) predicts that between 130-170 million people are estimated to have chronic Hepatitis C. Plants have various phytochemical compounds such as alkaloids and flavonoids that have prominent antiviral effects especially anti-HCV. The current HCV treatment still has limitations related to side effects and can lead to viral resistance. Therefore, it is necessary for the discovery and development of novel anti-HCV drugs for alternative and complementary medicine. Objective: This review intends to evaluate the alkaloids and flavonoids that have the potential to be used against HCV by looking at their classification and their mechanism of action. Methods: Twenty-one articles from 2010 to 2022 obtained from PUBMED database using keywords such as isolated compounds, alkaloids, flavonoids, hepatitis C virus. Results: 21 alkaloids and 37 flavonoids reported active against HCV. Alkaloids include quinoline, quinolizidine and isoquinoline. In addition, flavanone, flavonol, flavone, flavan-3-ol, flavonolignan, anthocyanidin and proanthocyanidin comprise flavonoids. The berberine alkaloids and eriodictyol 7-O-(6\u2032\u2032-caffeoyl)-\u03b2-D- glucopyranoside flavonoids had the lowest IC50 with values of 0.49 mM and 0.041 nM. Conclusions: Alkaloids and flavonoids compound had good activity against HCV with various mechanisms. Our results provide information of alkaloids and flavonoids to the researcher for the development of alternative and complementary medicine of hepatitis C.<\/jats:p>","DOI":"10.4081\/jphia.2023.2514","type":"journal-article","created":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T14:56:04Z","timestamp":1678978564000},"page":"9","source":"Crossref","is-referenced-by-count":3,"title":["Promising alkaloids and flavonoids compounds as anti-hepatitis c virus agents: a review"],"prefix":"10.4102","volume":"14","author":[{"given":"Gusti","family":"Rizaldi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achmad F.","family":"Hafid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tutik S.","family":"Wahyuni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2580","published-online":{"date-parts":[[2023,3,30]]},"reference":[{"key":"11942","doi-asserted-by":"crossref","unstructured":"Antonio ADS, Wiedemann LSM, Veiga-Junior VF. 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Conservation and sustainable use of medicinal plants: problems, progress, and prospects. Chin Med 2016;11:37.","DOI":"10.1186\/s13020-016-0108-7"},{"key":"11955","doi-asserted-by":"crossref","unstructured":"Kingston DGI. Modern natural products drug discovery and its relevance to biodiversity conservation. J Nat Prod 2011;74:496\u2013511.","DOI":"10.1021\/np100550t"},{"key":"11956","doi-asserted-by":"crossref","unstructured":"Newman DJ, Cragg GM. Natural products as sources of new drugs over the 30 years from 1981 to 2010. J Nat Prod 2012;75:311\u201335.","DOI":"10.1021\/np200906s"},{"key":"11957","doi-asserted-by":"crossref","unstructured":"Atanasov AG, Waltenberger B, Pferschy-Wenzig EM, et al. Discovery and resupply of pharmacologically active plant-derived natural products: A review. Biotechnol Adv 2015;33:1582\u2013614.","DOI":"10.1016\/j.biotechadv.2015.08.001"},{"key":"11958","doi-asserted-by":"crossref","unstructured":"Harvey AL, Edrada-Ebel R, Quinn RJ. 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