{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T01:34:17Z","timestamp":1648517657814},"reference-count":0,"publisher":"PAGEPress Publications","issue":"4","license":[{"start":{"date-parts":[[2004,12,30]],"date-time":"2004-12-30T00:00:00Z","timestamp":1104364800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Monaldi Arch Chest Dis"],"abstract":"<jats:p>Background. A low body mass index is one of the strongest predictors of mortality in Chronic Obstructive Pulmonary Disease (COPD) patients. Under-nutrition is often associated with skeletal muscle wasting and hypophosphatemia. Aim and Methods. In a pilot, randomised, doubleblind placebo-controlled study, we assessed the physiological effects of phosphorous administration in 17 stable undernourished COPD patients, on diaphragmatic function, breathing pattern, neuromuscular drive (P0.1) and dyspnea score. Fructose 1.6-diphosphate (FDP) or placebo was administered i.v. for 7 consecutive days. Results. FDP administration was associated with a marked increase in inspiratory time (Ti) that induced a significant rise (p&amp;lt;0.05) in the Pressure Time Product of the diaphragm per breath (PTPdi\/b). However, since breathing frequency also decreased, the Pressure Time Product per minute of the diaphragm (PTPdi\/min), index of diaphragmatic energy expenditure was markedly reduced. The efficiency of the respiratory pump in clearing CO2 was also improved, although not significantly, in the FDP group (p=0.09) as well as the maximal transdiaphragmatic pressure during the sniff manoeuvre (Pdi,sniff). Conclusions. This pilot physiological study showed that phosphorus replacement in undernourished, stable COPD patients, may be associated with a complex modification in respiratory pattern and diaphragmatic functions, leading to a marked although not significant reduction in PTPdi\/min.<\/jats:p>","DOI":"10.4081\/monaldi.2004.682","type":"journal-article","created":{"date-parts":[[2016,7,4]],"date-time":"2016-07-04T03:06:49Z","timestamp":1467601609000},"source":"Crossref","is-referenced-by-count":3,"title":["Physiological effects of intravenous fructose 1.6-diphosphate on diaphragmatic function in malnourished patients with COPD"],"prefix":"10.4081","volume":"61","author":[{"given":"S.","family":"Nava","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.M.","family":"Fuccella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Viglianti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2549","published-online":{"date-parts":[[2004,12,30]]},"container-title":["Monaldi Archives for Chest Disease"],"original-title":[],"link":[{"URL":"http:\/\/www.monaldi-archives.org\/index.php\/macd\/article\/viewFile\/682\/669","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2016,7,4]],"date-time":"2016-07-04T03:27:51Z","timestamp":1467602871000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.monaldi-archives.org\/index.php\/macd\/article\/view\/682"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12,30]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2004,12,30]]}},"URL":"https:\/\/doi.org\/10.4081\/monaldi.2004.682","relation":{},"ISSN":["2465-1028","1122-0643"],"issn-type":[{"value":"2465-1028","type":"electronic"},{"value":"1122-0643","type":"print"}],"subject":[],"published":{"date-parts":[[2004,12,30]]}}}