{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,4]],"date-time":"2024-08-04T17:58:11Z","timestamp":1722794291294},"reference-count":0,"publisher":"PAGEPress Publications","issue":"1","license":[{"start":{"date-parts":[[2016,1,25]],"date-time":"2016-01-25T00:00:00Z","timestamp":1453680000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Monaldi Arch Chest Dis"],"abstract":"<jats:p>Background and Aim. Nasal polyposis (NP) occurs in about 1-4% of the worldwide population. Increased plasma concentrations of different pro-inflammatory cytokines have been observed in NP, and might be related to the pathogenesis of this syndrome.The present study was designed to investigate IL-6 and IL-4 concentrations in nasal and oral exhaled breath condensate of patients with early and advanced NP, and following polypectomy. Methods. Ten individuals with polyposis in early status, twenty-three patients affected by advanced status of NP and ten healthy controls were enrolled into the study. Exhaled breath condensate was collected by all individuals, according to a previous standardised method. An immunoassay kit was used to measure IL-6 and IL-4 levels. Results. Concentrations of oral and nasal exhaled IL- 6 and IL-4 were significantly higher in patients with early nasal polyposis and advanced nasal polyposis, compared to healthy controls. A statistically significant decrease of nasally but not of orally exhaled IL-6 (p&amp;lt;0.001) and IL-4 (p&amp;lt;0.05) was observed after polypectomy. Conclusions. We consider oral and nasal exhaled condensate of IL-6 and IL-4 as valid inflammatory and oxidative stress marker in patients with nasal polyposis.<\/jats:p>","DOI":"10.4081\/monaldi.2009.369","type":"journal-article","created":{"date-parts":[[2016,1,25]],"date-time":"2016-01-25T20:08:51Z","timestamp":1453752531000},"source":"Crossref","is-referenced-by-count":0,"title":["Increased IL-6 and IL-4 in exhaled breath condensate of patients with nasal polyposis"],"prefix":"10.4081","volume":"71","author":[{"given":"G.E.","family":"Carpagnano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Carrat\u00f9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Gelardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Spanevello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Di Gioia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Condreva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Resta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.P.","family":"Foschino Barbaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2549","published-online":{"date-parts":[[2016,1,25]]},"container-title":["Monaldi Archives for Chest Disease"],"original-title":[],"link":[{"URL":"http:\/\/www.monaldi-archives.org\/index.php\/macd\/article\/viewFile\/369\/357","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2016,1,25]],"date-time":"2016-01-25T20:10:33Z","timestamp":1453752633000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.monaldi-archives.org\/index.php\/macd\/article\/view\/369"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,25]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2009,3,30]]}},"URL":"https:\/\/doi.org\/10.4081\/monaldi.2009.369","relation":{},"ISSN":["2465-1028","1122-0643"],"issn-type":[{"value":"2465-1028","type":"electronic"},{"value":"1122-0643","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1,25]]}}}