{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T15:41:08Z","timestamp":1648568468169},"reference-count":0,"publisher":"PAGEPress Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Monaldi Arch Chest Dis"],"abstract":"<jats:p>Familial hypercholesterolemia (FH) is a frequently undiagnosed genetic disease characterized by substantial elevations of low-density lipoprotein cholesterol (LDL-C). The prevalence of heterozygous FH (HeFH) in the general population is 1:500 inhabitants, while the prevalence of homozygous FH (HoFH) is 1:1.000.000. If FH is not identified and aggressively treated at an early age, affected individuals have a 20-fold increased lifetime risk of coronary heart disease compared with the general population. This narrative review provide a concise overview of recommendations for diagnosis and treatment of adults and children with FH, and discuss the utility of considering FH as a comorbidity at the entry of Cardiac Rehabilitation programmes.<\/jats:p>","DOI":"10.4081\/monaldi.2014.49","type":"journal-article","created":{"date-parts":[[2015,10,12]],"date-time":"2015-10-12T21:02:44Z","timestamp":1444683764000},"source":"Crossref","is-referenced-by-count":0,"title":["Familial Hypercholesterolemia in Cardiac Rehabilitation: a new field of interest"],"prefix":"10.4081","volume":"82","author":[{"given":"Marco","family":"Ambrosetti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella","family":"Malfatto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Maria","family":"Cremona","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcello","family":"Arca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pompilio","family":"Faggiano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2549","published-online":{"date-parts":[[2015,8,20]]},"container-title":["Monaldi Archives for Chest Disease"],"original-title":[],"link":[{"URL":"http:\/\/monaldi-archives.org\/index.php\/macd\/article\/viewFile\/49\/39","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2015,10,12]],"date-time":"2015-10-12T22:36:03Z","timestamp":1444689363000},"score":1,"resource":{"primary":{"URL":"http:\/\/monaldi-archives.org\/index.php\/macd\/article\/view\/49"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,20]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015,8,20]]}},"URL":"https:\/\/doi.org\/10.4081\/monaldi.2014.49","relation":{},"ISSN":["1122-0643"],"issn-type":[{"value":"1122-0643","type":"print"}],"subject":[],"published":{"date-parts":[[2015,8,20]]}}}